6OT2
Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 112 |
| Details | Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 68 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 152 |
| Details | Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 100 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 144 |
| Details | Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 124 |
| Details | Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 112 |
| Details | Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 116 |
| Details | Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 120 |
| Details | Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 128 |
| Details | Repeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 88 |
| Details | Repeat: {"description":"ANK 6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
