6OT2
Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 116 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | MET431-TYR460 | |
| B | MET431-TYR460 | |
| D | MET431-TYR460 | |
| C | MET431-TYR460 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 140 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | TYR461-MET479 | |
| D | LEU541-LYS545 | |
| D | ILE609-SER620 | |
| D | ASN647-LYS649 | |
| C | TYR461-MET479 | |
| C | LEU541-LYS545 | |
| C | ILE609-SER620 | |
| C | ASN647-LYS649 | |
| A | LEU541-LYS545 | |
| A | ILE609-SER620 | |
| A | ASN647-LYS649 | |
| B | TYR461-MET479 | |
| B | LEU541-LYS545 | |
| B | ILE609-SER620 | |
| B | ASN647-LYS649 | |
| D | TYR461-MET479 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 112 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | GLY480-LEU508 | |
| B | GLY480-LEU508 | |
| D | GLY480-LEU508 | |
| C | GLY480-LEU508 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 460 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | ARG509-ASP519 | |
| C | ARG509-ASP519 | |
| C | ARG567-PHE569 | |
| C | GLU687-VAL790 | |
| A | ARG567-PHE569 | |
| A | GLU687-VAL790 | |
| B | ARG509-ASP519 | |
| B | ARG567-PHE569 | |
| B | GLU687-VAL790 | |
| D | ARG509-ASP519 | |
| D | ARG567-PHE569 | |
| D | GLU687-VAL790 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | ALA520-TYR540 | |
| B | ALA520-TYR540 | |
| D | ALA520-TYR540 | |
| C | ALA520-TYR540 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | GLU546-THR566 | |
| B | GLU546-THR566 | |
| D | GLU546-THR566 | |
| C | GLU546-THR566 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 152 |
| Details | TRANSMEM: Helical; Name=S5 => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | GLN570-LEU608 | |
| B | GLN570-LEU608 | |
| D | GLN570-LEU608 | |
| C | GLN570-LEU608 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 100 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | SER621-GLN646 | |
| B | SER621-GLN646 | |
| D | SER621-GLN646 | |
| C | SER621-GLN646 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 144 |
| Details | TRANSMEM: Helical; Name=S6 => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O |
| Chain | Residue | Details |
| A | TYR650-LYS686 | |
| B | TYR650-LYS686 | |
| D | TYR650-LYS686 | |
| C | TYR650-LYS686 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6M |
| Chain | Residue | Details |
| A | GLY638 | |
| B | GLY638 | |
| D | GLY638 | |
| C | GLY638 |
