6ORA

An Unexpected Intermediate in the Reaction Catalyzed by Quinolinate Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008987	molecular_function	quinolinate synthetase A activity
A	0009435	biological_process	NAD+ biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019805	biological_process	quinolinate biosynthetic process
A	0034628	biological_process	'de novo' NAD+ biosynthetic process from L-aspartate
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0005737	cellular_component	cytoplasm
B	0008987	molecular_function	quinolinate synthetase A activity
B	0009435	biological_process	NAD+ biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019805	biological_process	quinolinate biosynthetic process
B	0034628	biological_process	'de novo' NAD+ biosynthetic process from L-aspartate
B	0046872	molecular_function	metal ion binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SF4 A 401

Chain	Residue
A	CYS83
A	ASN111
A	CYS170
A	GLN198
A	CYS256
A	5XW403

---

site_id	AC2
Number of Residues	2
Details	binding site for residue ACT A 402

Chain	Residue
A	ARG43
A	SER299

---

site_id	AC3
Number of Residues	15
Details	binding site for residue 5XW A 403

Chain	Residue
A	TYR23
A	ASP37
A	SER38
A	LEU39
A	TYR109
A	ASN111
A	THR125
A	SER126
A	ALA127
A	HIS196
A	GLN198
A	SER212
A	THR213
A	SF4401
A	HIS21

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 404

Chain	Residue
A	ARG44
A	VAL48
A	ASP49
A	ALA50

---

site_id	AC5
Number of Residues	7
Details	binding site for residue SF4 B 401

Chain	Residue
B	CYS83
B	ASN111
B	CYS170
B	VAL172
B	GLN198
B	CYS256
B	5XR403

---

site_id	AC6
Number of Residues	3
Details	binding site for residue ACT B 402

Chain	Residue
B	LEU187
B	PRO189
B	HOH518

---

site_id	AC7
Number of Residues	15
Details	binding site for residue 5XR B 403

Chain	Residue
B	HIS21
B	TYR23
B	ASP37
B	SER38
B	LEU39
B	TYR109
B	ASN111
B	THR125
B	SER126
B	ALA127
B	HIS196
B	GLN198
B	SER212
B	THR213
B	SF4401

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CL B 404

Chain	Residue
B	ILE17
B	ARG44
B	ASP49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00568","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31390192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15937336","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27224840","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27404889","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00568","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27224840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27404889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31390192","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KTN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KTO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KTT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00568","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31390192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15937336","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27404889","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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