6OR2
MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine
Replaces: 6N3TFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue L9Q A 801 |
| Chain | Residue |
| A | GLN40 |
| A | ARG501 |
| A | PRO502 |
| A | ASN504 |
| A | GLN517 |
| A | THR549 |
| A | PHE43 |
| A | ASP64 |
| A | VAL70 |
| A | LEU171 |
| A | LEU174 |
| A | PHE452 |
| A | ARG453 |
| A | THR454 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue LMT A 802 |
| Chain | Residue |
| A | LEU424 |
| A | GLN554 |
| A | ILE557 |
| A | PHE561 |
| A | LEU564 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 131 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | MET1-TYR14 | |
| A | VAL262-VAL290 | |
| A | ALA339-PRO401 | |
| A | PRO589-LYS591 | |
| A | SER652-LEU678 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE15-GLY35 | |
| A | MET631-VAL651 | |
| A | ILE679-VAL699 | |
| A | LEU704-VAL724 | |
| A | VAL197-ILE217 | |
| A | GLY218-VAL238 | |
| A | PHE241-ILE261 | |
| A | VAL291-PHE311 | |
| A | ALA318-LEU338 | |
| A | ILE402-LEU422 | |
| A | ALA568-LEU588 | |
| A | ALA592-VAL612 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 330 |
| Details | TOPO_DOM: Periplasmic => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | ASN36-LEU196 | |
| A | HIS239-PHE240 | |
| A | LEU312-TYR317 | |
| A | SER423-MET567 | |
| A | ASP613-PRO630 | |
| A | MET700-TYR703 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31113875, ECO:0007744|PDB:6OR2 |
| Chain | Residue | Details |
| A | GLN40 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30682372, ECO:0007744|PDB:6AJG |
| Chain | Residue | Details |
| A | ASP645 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Part of the proton-transportation channel => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | ASP256 | |
| A | TYR257 | |
| A | TYR646 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Part of the proton transportation network => ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | LYS591 | |
| A | GLU647 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Part of the proton-transportation channel => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875, ECO:0000305|PubMed:32512002 |
| Chain | Residue | Details |
| A | ASP645 |
