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6OQT

E. coli ATP synthase State 1c

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006754biological_processATP biosynthetic process
A0015986biological_processproton motive force-driven ATP synthesis
A0016020cellular_componentmembrane
A0032559molecular_functionadenyl ribonucleotide binding
A0042777biological_processproton motive force-driven plasma membrane ATP synthesis
A0043531molecular_functionADP binding
A0045259cellular_componentproton-transporting ATP synthase complex
A0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
A0046034biological_processATP metabolic process
A0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
A0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
A1902600biological_processproton transmembrane transport
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006754biological_processATP biosynthetic process
B0015986biological_processproton motive force-driven ATP synthesis
B0016020cellular_componentmembrane
B0032559molecular_functionadenyl ribonucleotide binding
B0042777biological_processproton motive force-driven plasma membrane ATP synthesis
B0043531molecular_functionADP binding
B0045259cellular_componentproton-transporting ATP synthase complex
B0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
B0046034biological_processATP metabolic process
B0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
B0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
B1902600biological_processproton transmembrane transport
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006754biological_processATP biosynthetic process
C0015986biological_processproton motive force-driven ATP synthesis
C0016020cellular_componentmembrane
C0032559molecular_functionadenyl ribonucleotide binding
C0042777biological_processproton motive force-driven plasma membrane ATP synthesis
C0043531molecular_functionADP binding
C0045259cellular_componentproton-transporting ATP synthase complex
C0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
C0046034biological_processATP metabolic process
C0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
C0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
C1902600biological_processproton transmembrane transport
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006754biological_processATP biosynthetic process
D0015986biological_processproton motive force-driven ATP synthesis
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0042777biological_processproton motive force-driven plasma membrane ATP synthesis
D0045259cellular_componentproton-transporting ATP synthase complex
D0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
D0046034biological_processATP metabolic process
D0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
D0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
D1902600biological_processproton transmembrane transport
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005886cellular_componentplasma membrane
E0006754biological_processATP biosynthetic process
E0015986biological_processproton motive force-driven ATP synthesis
E0016020cellular_componentmembrane
E0016887molecular_functionATP hydrolysis activity
E0042777biological_processproton motive force-driven plasma membrane ATP synthesis
E0045259cellular_componentproton-transporting ATP synthase complex
E0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
E0046034biological_processATP metabolic process
E0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
E0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
E1902600biological_processproton transmembrane transport
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005886cellular_componentplasma membrane
F0006754biological_processATP biosynthetic process
F0015986biological_processproton motive force-driven ATP synthesis
F0016020cellular_componentmembrane
F0016887molecular_functionATP hydrolysis activity
F0042777biological_processproton motive force-driven plasma membrane ATP synthesis
F0045259cellular_componentproton-transporting ATP synthase complex
F0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
F0046034biological_processATP metabolic process
F0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
F0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
F1902600biological_processproton transmembrane transport
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005886cellular_componentplasma membrane
G0006754biological_processATP biosynthetic process
G0015986biological_processproton motive force-driven ATP synthesis
G0016020cellular_componentmembrane
G0042777biological_processproton motive force-driven plasma membrane ATP synthesis
G0045259cellular_componentproton-transporting ATP synthase complex
G0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
G0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
G0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
G1902600biological_processproton transmembrane transport
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005886cellular_componentplasma membrane
H0006754biological_processATP biosynthetic process
H0015986biological_processproton motive force-driven ATP synthesis
H0042777biological_processproton motive force-driven plasma membrane ATP synthesis
H0045259cellular_componentproton-transporting ATP synthase complex
H0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
H0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
H1902600biological_processproton transmembrane transport
I0005886cellular_componentplasma membrane
I0006754biological_processATP biosynthetic process
I0008289molecular_functionlipid binding
I0015078molecular_functionproton transmembrane transporter activity
I0015986biological_processproton motive force-driven ATP synthesis
I0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
I0042777biological_processproton motive force-driven plasma membrane ATP synthesis
I0045259cellular_componentproton-transporting ATP synthase complex
I0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
I0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
I0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
I1902600biological_processproton transmembrane transport
J0005886cellular_componentplasma membrane
J0006754biological_processATP biosynthetic process
J0008289molecular_functionlipid binding
J0015078molecular_functionproton transmembrane transporter activity
J0015986biological_processproton motive force-driven ATP synthesis
J0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
J0042777biological_processproton motive force-driven plasma membrane ATP synthesis
J0045259cellular_componentproton-transporting ATP synthase complex
J0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
J0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
J0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
J1902600biological_processproton transmembrane transport
L0005886cellular_componentplasma membrane
L0006754biological_processATP biosynthetic process
L0008289molecular_functionlipid binding
L0015078molecular_functionproton transmembrane transporter activity
L0015986biological_processproton motive force-driven ATP synthesis
L0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
L0042777biological_processproton motive force-driven plasma membrane ATP synthesis
L0045259cellular_componentproton-transporting ATP synthase complex
L0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
L0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
L0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
L1902600biological_processproton transmembrane transport
M0005886cellular_componentplasma membrane
M0006754biological_processATP biosynthetic process
M0008289molecular_functionlipid binding
M0015078molecular_functionproton transmembrane transporter activity
M0015986biological_processproton motive force-driven ATP synthesis
M0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
M0042777biological_processproton motive force-driven plasma membrane ATP synthesis
M0045259cellular_componentproton-transporting ATP synthase complex
M0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
M0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
M0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
M1902600biological_processproton transmembrane transport
N0005886cellular_componentplasma membrane
N0006754biological_processATP biosynthetic process
N0008289molecular_functionlipid binding
N0015078molecular_functionproton transmembrane transporter activity
N0015986biological_processproton motive force-driven ATP synthesis
N0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
N0042777biological_processproton motive force-driven plasma membrane ATP synthesis
N0045259cellular_componentproton-transporting ATP synthase complex
N0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
N0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
N0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
N1902600biological_processproton transmembrane transport
O0005886cellular_componentplasma membrane
O0006754biological_processATP biosynthetic process
O0008289molecular_functionlipid binding
O0015078molecular_functionproton transmembrane transporter activity
O0015986biological_processproton motive force-driven ATP synthesis
O0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
O0042777biological_processproton motive force-driven plasma membrane ATP synthesis
O0045259cellular_componentproton-transporting ATP synthase complex
O0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
O0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
O0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
O1902600biological_processproton transmembrane transport
P0005886cellular_componentplasma membrane
P0006754biological_processATP biosynthetic process
P0008289molecular_functionlipid binding
P0015078molecular_functionproton transmembrane transporter activity
P0015986biological_processproton motive force-driven ATP synthesis
P0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
P0042777biological_processproton motive force-driven plasma membrane ATP synthesis
P0045259cellular_componentproton-transporting ATP synthase complex
P0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
P0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
P0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
P1902600biological_processproton transmembrane transport
Q0005886cellular_componentplasma membrane
Q0006754biological_processATP biosynthetic process
Q0008289molecular_functionlipid binding
Q0015078molecular_functionproton transmembrane transporter activity
Q0015986biological_processproton motive force-driven ATP synthesis
Q0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
Q0042777biological_processproton motive force-driven plasma membrane ATP synthesis
Q0045259cellular_componentproton-transporting ATP synthase complex
Q0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
Q0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
Q0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
Q1902600biological_processproton transmembrane transport
R0005886cellular_componentplasma membrane
R0006754biological_processATP biosynthetic process
R0008289molecular_functionlipid binding
R0015078molecular_functionproton transmembrane transporter activity
R0015986biological_processproton motive force-driven ATP synthesis
R0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
R0042777biological_processproton motive force-driven plasma membrane ATP synthesis
R0045259cellular_componentproton-transporting ATP synthase complex
R0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
R0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
R0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
R1902600biological_processproton transmembrane transport
S0005886cellular_componentplasma membrane
S0006754biological_processATP biosynthetic process
S0008289molecular_functionlipid binding
S0015078molecular_functionproton transmembrane transporter activity
S0015986biological_processproton motive force-driven ATP synthesis
S0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
S0042777biological_processproton motive force-driven plasma membrane ATP synthesis
S0045259cellular_componentproton-transporting ATP synthase complex
S0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
S0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
S0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
S1902600biological_processproton transmembrane transport
W0005886cellular_componentplasma membrane
W0006754biological_processATP biosynthetic process
W0015986biological_processproton motive force-driven ATP synthesis
W0016020cellular_componentmembrane
W0042777biological_processproton motive force-driven plasma membrane ATP synthesis
W0045259cellular_componentproton-transporting ATP synthase complex
W0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
W0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
W0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
W1902600biological_processproton transmembrane transport
X0005886cellular_componentplasma membrane
X0006754biological_processATP biosynthetic process
X0015078molecular_functionproton transmembrane transporter activity
X0015986biological_processproton motive force-driven ATP synthesis
X0042777biological_processproton motive force-driven plasma membrane ATP synthesis
X0045259cellular_componentproton-transporting ATP synthase complex
X0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
X0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
X0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
X1902600biological_processproton transmembrane transport
Y0005886cellular_componentplasma membrane
Y0006754biological_processATP biosynthetic process
Y0015078molecular_functionproton transmembrane transporter activity
Y0015986biological_processproton motive force-driven ATP synthesis
Y0042777biological_processproton motive force-driven plasma membrane ATP synthesis
Y0045259cellular_componentproton-transporting ATP synthase complex
Y0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
Y0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
Y0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
Y1902600biological_processproton transmembrane transport
a0005886cellular_componentplasma membrane
a0006754biological_processATP biosynthetic process
a0015078molecular_functionproton transmembrane transporter activity
a0015986biological_processproton motive force-driven ATP synthesis
a0042777biological_processproton motive force-driven plasma membrane ATP synthesis
a0045259cellular_componentproton-transporting ATP synthase complex
a0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
a0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
a0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
a1902600biological_processproton transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue ATP C 600
ChainResidue
CGLN172
CGLN435
CMG601
FARG342
FASP345
CTHR173
CGLY174
CLYS175
CTHR176
CALA177
CPHE360
CARG365
CGLN433

site_idAC2
Number of Residues2
Detailsbinding site for residue MG C 601
ChainResidue
CTHR176
CATP600

site_idAC3
Number of Residues13
Detailsbinding site for residue ATP B 600
ChainResidue
BGLN172
BTHR173
BGLY174
BLYS175
BTHR176
BALA177
BPHE360
BARG365
BGLN433
BGLN435
BMG601
EARG342
EASP345

site_idAC4
Number of Residues2
Detailsbinding site for residue MG B 601
ChainResidue
BTHR176
BATP600

site_idAC5
Number of Residues12
Detailsbinding site for residue ATP A 600
ChainResidue
AGLN172
ATHR173
AGLY174
ALYS175
ATHR176
AALA177
APHE360
AARG365
AGLN433
AGLN435
AMG601
DARG342

site_idAC6
Number of Residues2
Detailsbinding site for residue MG A 601
ChainResidue
ATHR176
AATP600

site_idAC7
Number of Residues11
Detailsbinding site for residue ADP F 500
ChainResidue
BARG376
FGLY152
FGLY154
FLYS155
FTHR156
FVAL157
FTYR331
FPHE404
FALA407
FPHE410
FMG501

site_idAC8
Number of Residues3
Detailsbinding site for residue MG F 501
ChainResidue
FTHR156
FGLU181
FADP500

site_idAC9
Number of Residues10
Detailsbinding site for residue ADP E 500
ChainResidue
EGLY152
EVAL153
EGLY154
ELYS155
ETHR156
EVAL157
ETYR331
EPHE404
EALA407
ETHR411

site_idAD1
Number of Residues12
Detailsbinding site for residue ADP D 500
ChainResidue
CARG376
DALA151
DGLY152
DGLY154
DLYS155
DTHR156
DVAL157
DTYR331
DALA407
DPHE410
DPO4501
DMG502

site_idAD2
Number of Residues7
Detailsbinding site for residue PO4 D 501
ChainResidue
CARG376
DLYS155
DARG182
DASN243
DARG246
DADP500
DMG502

site_idAD3
Number of Residues3
Detailsbinding site for residue MG D 502
ChainResidue
DTHR156
DADP500
DPO4501

Functional Information from PROSITE/UniProt
site_idPS00152
Number of Residues10
DetailsATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVNPGISVS
ChainResidueDetails
CPRO366-SER375
FPRO332-SER341

site_idPS00153
Number of Residues14
DetailsATPASE_GAMMA ATP synthase gamma subunit signature. ITqEltEivsGAaA
ChainResidueDetails
GILE272-ALA285

site_idPS00389
Number of Residues20
DetailsATPASE_DELTA ATP synthase delta (OSCP) subunit signature. VkLnakIDkSVmAGVIIRaG
ChainResidueDetails
WVAL136-GLY155

site_idPS00449
Number of Residues10
DetailsATPASE_A ATP synthase a subunit signature. SLGLRLFGNM
ChainResidueDetails
aSER206-MET215

site_idPS00605
Number of Residues22
DetailsATPASE_C ATP synthase c subunit signature. ARQPdliplLrTqfFIvmgLvD
ChainResidueDetails
JALA40-ASP61

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues63
DetailsTOPO_DOM: Periplasmic => ECO:0000305
ChainResidueDetails
aMET1-TRP39
OVAL74-ALA79
PMET1-TYR10
PVAL74-ALA79
QMET1-TYR10
QVAL74-ALA79
RMET1-TYR10
RVAL74-ALA79
IMET1-TYR10
IVAL74-ALA79
SMET1-TYR10
aLEU121-ALA145
SVAL74-ALA79
aTRP241
LVAL74-ALA79
MMET1-TYR10
MVAL74-ALA79
NMET1-TYR10
NVAL74-ALA79
OMET1-TYR10

site_idSWS_FT_FI2
Number of Residues100
DetailsTRANSMEM: Helical => ECO:0000305
ChainResidueDetails
aTHR40-PHE60
OPHE53-TYR73
PMET11-LEU31
PPHE53-TYR73
QMET11-LEU31
QPHE53-TYR73
RMET11-LEU31
RPHE53-TYR73
IMET11-LEU31
IPHE53-TYR73
SMET11-LEU31
aLEU100-LEU120
SPHE53-TYR73
aASP146-ILE166
aLEU220-PRO240
aALA242-VAL262
MPHE53-TYR73
NMET11-LEU31
NPHE53-TYR73
OMET11-LEU31

site_idSWS_FT_FI3
Number of Residues98
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
aARG61-LYS99
SGLY32-GLN52
aLYS167-GLU219
aTYR263-HIS271
NGLY32-GLN52
OGLY32-GLN52
PGLY32-GLN52
QGLY32-GLN52
RGLY32-GLN52
IGLY32-GLN52

site_idSWS_FT_FI4
Number of Residues10
DetailsSITE: Reversibly protonated during proton transport
ChainResidueDetails
JASP61
SASP61
LASP61
MASP61
NASP61
OASP61
PASP61
QASP61
RASP61
IASP61

site_idSWS_FT_FI5
Number of Residues10
DetailsMOD_RES: N-formylmethionine => ECO:0000250
ChainResidueDetails
JMET1
SMET1
LMET1
MMET1
NMET1
OMET1
PMET1
QMET1
RMET1
IMET1

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 507
ChainResidueDetails
aSER206proton acceptor, proton donor, proton relay
aARG210electrostatic stabiliser
aASN214proton acceptor

site_idMCSA10
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
SASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA2
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
LASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA3
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
MASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA4
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
NASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA5
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
OASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA6
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
PASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA7
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
QASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA8
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
RASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA9
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
IASP61electrostatic stabiliser, proton acceptor, proton donor

227344

PDB entries from 2024-11-13

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