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6OPS

HIV-1 Protease NL4-3 WT in complex with darunavir

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0016787molecular_functionhydrolase activity
A0044174cellular_componenthost cell endosome
A0055036cellular_componentvirion membrane
A0072494cellular_componenthost multivesicular body
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0016787molecular_functionhydrolase activity
B0044174cellular_componenthost cell endosome
B0055036cellular_componentvirion membrane
B0072494cellular_componenthost multivesicular body
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue 017 A 101
ChainResidue
AASP25
AVAL82
AILE84
AHOH227
BARG8
BLEU23
BASP25
BGLY27
BALA28
BASP30
BVAL32
AGLY27
BGLY48
BGLY49
BPRO81
BVAL82
BILE84
BHOH133
AALA28
AASP29
AASP30
AVAL32
AGLY48
AGLY49
AILE50

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
ChainResidueDetails
BALA22-LEU33

237735

PDB entries from 2025-06-18

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