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6OOY

Asymmetric hTNF-alpha

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MRD A 201
ChainResidue
ASER60
ALEU120
AHOH302
BTYR119
CTYR119
CA7M201

site_idAC2
Number of Residues11
Detailsbinding site for residue A7M C 201
ChainResidue
BTYR119
BGLY121
BGLY122
CTYR59
CSER60
CTYR119
CLEU120
CTYR151
ALEU57
ATYR59
AMRD201

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000269|PubMed:8631363
ChainResidueDetails
ASER4
BSER4
CSER4

229183

PDB entries from 2024-12-18

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