Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ONC

Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase produced without CooC, as-isolated

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004601	molecular_function	peroxidase activity
A	0006091	biological_process	generation of precursor metabolites and energy
A	0016151	molecular_function	nickel cation binding
A	0016491	molecular_function	oxidoreductase activity
A	0042542	biological_process	response to hydrogen peroxide
A	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
A	0050418	molecular_function	hydroxylamine reductase activity
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0098869	biological_process	cellular oxidant detoxification
B	0003824	molecular_function	catalytic activity
B	0004601	molecular_function	peroxidase activity
B	0006091	biological_process	generation of precursor metabolites and energy
B	0016151	molecular_function	nickel cation binding
B	0016491	molecular_function	oxidoreductase activity
B	0042542	biological_process	response to hydrogen peroxide
B	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
B	0050418	molecular_function	hydroxylamine reductase activity
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0098869	biological_process	cellular oxidant detoxification
C	0003824	molecular_function	catalytic activity
C	0004601	molecular_function	peroxidase activity
C	0006091	biological_process	generation of precursor metabolites and energy
C	0016151	molecular_function	nickel cation binding
C	0016491	molecular_function	oxidoreductase activity
C	0042542	biological_process	response to hydrogen peroxide
C	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
C	0050418	molecular_function	hydroxylamine reductase activity
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0098869	biological_process	cellular oxidant detoxification
D	0003824	molecular_function	catalytic activity
D	0004601	molecular_function	peroxidase activity
D	0006091	biological_process	generation of precursor metabolites and energy
D	0016151	molecular_function	nickel cation binding
D	0016491	molecular_function	oxidoreductase activity
D	0042542	biological_process	response to hydrogen peroxide
D	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
D	0050418	molecular_function	hydroxylamine reductase activity
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SF4 A 701

Chain	Residue
A	CYS51
A	CYS54
A	CYS59
A	CYS74
A	ARG84
A	MET203

site_id	AC2
Number of Residues	12
Details	binding site for residue XCC A 702

Chain	Residue
A	GLY447
A	CYS448
A	CYS478
A	CYS519
A	TYR553
A	SER554
A	LYS556
A	FE703
A	HOH948
A	HIS266
A	CYS302
A	CYS340

site_id	AC3
Number of Residues	4
Details	binding site for residue FE A 703

Chain	Residue
A	CYS302
A	CYS519
A	XCC702
A	HOH948

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 704

Chain	Residue
A	PHE44
A	ARG60
A	HOH925
B	ARG60

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 705

Chain	Residue
A	HOH827
A	HOH865
A	HOH969
A	HOH1074
A	HOH1292
A	HOH1415

site_id	AC6
Number of Residues	6
Details	binding site for residue FES B 701

Chain	Residue
A	CYS42
A	CYS45
A	THR50
B	CYS42
B	CYS45
B	THR50

site_id	AC7
Number of Residues	6
Details	binding site for residue SF4 B 702

Chain	Residue
B	CYS51
B	CYS54
B	CYS59
B	CYS74
B	ARG84
B	MET203

site_id	AC8
Number of Residues	12
Details	binding site for residue XCC B 703

Chain	Residue
B	HIS266
B	CYS302
B	HIS319
B	CYS340
B	GLY447
B	CYS448
B	CYS478
B	CYS519
B	TYR553
B	SER554
B	FE704
B	HOH913

site_id	AC9
Number of Residues	4
Details	binding site for residue FE B 704

Chain	Residue
B	CYS302
B	CYS519
B	XCC703
B	HOH913

site_id	AD1
Number of Residues	6
Details	binding site for residue MG B 705

Chain	Residue
B	HOH994
B	HOH1022
B	HOH1028
B	HOH1205
B	HOH1309
B	HOH1483

site_id	AD2
Number of Residues	3
Details	binding site for residue MG B 706

Chain	Residue
A	HOH1309
B	HOH822
B	HOH968

site_id	AD3
Number of Residues	3
Details	binding site for residue CL B 707

Chain	Residue
B	ASN164
B	ALA165
B	HOH1291

site_id	AD4
Number of Residues	7
Details	binding site for residue SF4 C 701

Chain	Residue
C	CYS51
C	ASN53
C	CYS54
C	CYS59
C	CYS74
C	ARG84
C	MET203

site_id	AD5
Number of Residues	11
Details	binding site for residue XCC C 702

Chain	Residue
C	HIS266
C	CYS302
C	CYS340
C	GLY447
C	CYS448
C	CYS478
C	CYS519
C	TYR553
C	SER554
C	FE703
C	HOH971

site_id	AD6
Number of Residues	4
Details	binding site for residue FE C 703

Chain	Residue
C	CYS302
C	CYS519
C	XCC702
C	HOH971

site_id	AD7
Number of Residues	6
Details	binding site for residue GOL C 704

Chain	Residue
C	HOH1145
C	ASP79
C	SER582
C	GLU583
C	ASN584
C	HOH1010

site_id	AD8
Number of Residues	6
Details	binding site for residue MG C 705

Chain	Residue
C	HOH1023
C	HOH1042
C	HOH1119
C	HOH1126
C	HOH1308
C	HOH1463

site_id	AD9
Number of Residues	5
Details	binding site for residue MG C 706

Chain	Residue
C	HOH877
C	HOH1046
C	HOH1414
D	HOH1313
D	HOH1344

site_id	AE1
Number of Residues	3
Details	binding site for residue CL C 707

Chain	Residue
C	ARG163
C	ASN164
C	ALA165

site_id	AE2
Number of Residues	6
Details	binding site for residue FES D 701

Chain	Residue
C	CYS42
C	CYS45
C	THR50
D	CYS42
D	CYS45
D	THR50

site_id	AE3
Number of Residues	6
Details	binding site for residue SF4 D 702

Chain	Residue
D	CYS51
D	CYS54
D	CYS59
D	CYS74
D	ARG84
D	MET203

site_id	AE4
Number of Residues	11
Details	binding site for residue XCC D 703

Chain	Residue
D	HIS266
D	CYS302
D	CYS340
D	GLY447
D	CYS448
D	CYS478
D	CYS519
D	TYR553
D	SER554
D	FE704
D	HOH868

site_id	AE5
Number of Residues	4
Details	binding site for residue FE D 704

Chain	Residue
D	CYS302
D	CYS519
D	XCC703
D	HOH868

site_id	AE6
Number of Residues	7
Details	binding site for residue GOL D 705

Chain	Residue
D	ASP79
D	GLY581
D	SER582
D	GLU583
D	ASN584
D	HOH839
D	HOH951

site_id	AE7
Number of Residues	6
Details	binding site for residue MG D 706

Chain	Residue
D	HOH856
D	HOH892
D	HOH1012
D	HOH1148
D	HOH1254
D	HOH1416

site_id	AE8
Number of Residues	5
Details	binding site for residue MG D 707

Chain	Residue
D	GLN406
D	HOH838
D	HOH1077
D	HOH1192
D	HOH1385

site_id	AE9
Number of Residues	5
Details	binding site for residue MG D 708

Chain	Residue
C	HOH1272
C	HOH1338
D	HOH816
D	HOH900
D	HOH1402

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Motif: {"description":"CXXC; D cluster binding","evidences":[{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32655979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31296570","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DC2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ONC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OND","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR005023-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31296570","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35278753","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DC2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ONC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OND","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ONS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TSJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR005023-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32655979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DC2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VWY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Binds C cluster in the oxidized state, but not in the canonical reduced state","evidences":[{"source":"PubMed","id":"30277213","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)