6OMB

Cdc48 Hexamer (Subunits A to E) with substrate bound to the central pore

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000837	cellular_component	Doa10p ubiquitin ligase complex
A	0000839	cellular_component	Hrd1p ubiquitin ligase ERAD-L complex
A	0003689	molecular_function	DNA clamp loader activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006274	biological_process	DNA replication termination
A	0006338	biological_process	chromatin remodeling
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0010636	biological_process	positive regulation of mitochondrial fusion
A	0015031	biological_process	protein transport
A	0016236	biological_process	macroautophagy
A	0016320	biological_process	endoplasmic reticulum membrane fusion
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019888	molecular_function	protein phosphatase regulator activity
A	0030894	cellular_component	replisome
A	0030970	biological_process	retrograde protein transport, ER to cytosol
A	0031134	biological_process	sister chromatid biorientation
A	0031593	molecular_function	polyubiquitin modification-dependent protein binding
A	0032984	biological_process	protein-containing complex disassembly
A	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
A	0034517	biological_process	ribophagy
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0036266	cellular_component	Cdc48p-Npl4p-Vms1p AAA ATPase complex
A	0036503	biological_process	ERAD pathway
A	0042802	molecular_function	identical protein binding
A	0043130	molecular_function	ubiquitin binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043328	biological_process	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
A	0043332	cellular_component	mating projection tip
A	0046034	biological_process	ATP metabolic process
A	0051228	biological_process	mitotic spindle disassembly
A	0061775	molecular_function	cohesin loader activity
A	0070651	biological_process	nonfunctional rRNA decay
A	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
A	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
A	0072344	biological_process	rescue of stalled ribosome
A	0072671	biological_process	mitochondria-associated ubiquitin-dependent protein catabolic process
A	0097352	biological_process	autophagosome maturation
A	0099638	biological_process	endosome to plasma membrane protein transport
A	0120174	biological_process	stress-induced homeostatically regulated protein degradation pathway
A	0140584	molecular_function	chromatin extrusion motor activity
A	0140588	biological_process	chromatin looping
A	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
A	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
A	1900182	biological_process	positive regulation of protein localization to nucleus
A	1902979	biological_process	mitotic DNA replication termination
A	1990112	cellular_component	RQC complex
A	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
A	1990171	biological_process	SCF complex disassembly in response to cadmium stress
B	0000837	cellular_component	Doa10p ubiquitin ligase complex
B	0000839	cellular_component	Hrd1p ubiquitin ligase ERAD-L complex
B	0003689	molecular_function	DNA clamp loader activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006274	biological_process	DNA replication termination
B	0006338	biological_process	chromatin remodeling
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0010636	biological_process	positive regulation of mitochondrial fusion
B	0015031	biological_process	protein transport
B	0016236	biological_process	macroautophagy
B	0016320	biological_process	endoplasmic reticulum membrane fusion
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019888	molecular_function	protein phosphatase regulator activity
B	0030894	cellular_component	replisome
B	0030970	biological_process	retrograde protein transport, ER to cytosol
B	0031134	biological_process	sister chromatid biorientation
B	0031593	molecular_function	polyubiquitin modification-dependent protein binding
B	0032984	biological_process	protein-containing complex disassembly
B	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
B	0034517	biological_process	ribophagy
B	0034727	biological_process	piecemeal microautophagy of the nucleus
B	0036266	cellular_component	Cdc48p-Npl4p-Vms1p AAA ATPase complex
B	0036503	biological_process	ERAD pathway
B	0042802	molecular_function	identical protein binding
B	0043130	molecular_function	ubiquitin binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043328	biological_process	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
B	0043332	cellular_component	mating projection tip
B	0046034	biological_process	ATP metabolic process
B	0051228	biological_process	mitotic spindle disassembly
B	0061775	molecular_function	cohesin loader activity
B	0070651	biological_process	nonfunctional rRNA decay
B	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
B	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
B	0072344	biological_process	rescue of stalled ribosome
B	0072671	biological_process	mitochondria-associated ubiquitin-dependent protein catabolic process
B	0097352	biological_process	autophagosome maturation
B	0099638	biological_process	endosome to plasma membrane protein transport
B	0120174	biological_process	stress-induced homeostatically regulated protein degradation pathway
B	0140584	molecular_function	chromatin extrusion motor activity
B	0140588	biological_process	chromatin looping
B	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
B	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
B	1900182	biological_process	positive regulation of protein localization to nucleus
B	1902979	biological_process	mitotic DNA replication termination
B	1990112	cellular_component	RQC complex
B	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
B	1990171	biological_process	SCF complex disassembly in response to cadmium stress
C	0000837	cellular_component	Doa10p ubiquitin ligase complex
C	0000839	cellular_component	Hrd1p ubiquitin ligase ERAD-L complex
C	0003689	molecular_function	DNA clamp loader activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0006274	biological_process	DNA replication termination
C	0006338	biological_process	chromatin remodeling
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0010636	biological_process	positive regulation of mitochondrial fusion
C	0015031	biological_process	protein transport
C	0016236	biological_process	macroautophagy
C	0016320	biological_process	endoplasmic reticulum membrane fusion
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0019888	molecular_function	protein phosphatase regulator activity
C	0030894	cellular_component	replisome
C	0030970	biological_process	retrograde protein transport, ER to cytosol
C	0031134	biological_process	sister chromatid biorientation
C	0031593	molecular_function	polyubiquitin modification-dependent protein binding
C	0032984	biological_process	protein-containing complex disassembly
C	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
C	0034517	biological_process	ribophagy
C	0034727	biological_process	piecemeal microautophagy of the nucleus
C	0036266	cellular_component	Cdc48p-Npl4p-Vms1p AAA ATPase complex
C	0036503	biological_process	ERAD pathway
C	0042802	molecular_function	identical protein binding
C	0043130	molecular_function	ubiquitin binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043328	biological_process	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
C	0043332	cellular_component	mating projection tip
C	0046034	biological_process	ATP metabolic process
C	0051228	biological_process	mitotic spindle disassembly
C	0061775	molecular_function	cohesin loader activity
C	0070651	biological_process	nonfunctional rRNA decay
C	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
C	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
C	0072344	biological_process	rescue of stalled ribosome
C	0072671	biological_process	mitochondria-associated ubiquitin-dependent protein catabolic process
C	0097352	biological_process	autophagosome maturation
C	0099638	biological_process	endosome to plasma membrane protein transport
C	0120174	biological_process	stress-induced homeostatically regulated protein degradation pathway
C	0140584	molecular_function	chromatin extrusion motor activity
C	0140588	biological_process	chromatin looping
C	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
C	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
C	1900182	biological_process	positive regulation of protein localization to nucleus
C	1902979	biological_process	mitotic DNA replication termination
C	1990112	cellular_component	RQC complex
C	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
C	1990171	biological_process	SCF complex disassembly in response to cadmium stress
D	0000837	cellular_component	Doa10p ubiquitin ligase complex
D	0000839	cellular_component	Hrd1p ubiquitin ligase ERAD-L complex
D	0003689	molecular_function	DNA clamp loader activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0006274	biological_process	DNA replication termination
D	0006338	biological_process	chromatin remodeling
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0010636	biological_process	positive regulation of mitochondrial fusion
D	0015031	biological_process	protein transport
D	0016236	biological_process	macroautophagy
D	0016320	biological_process	endoplasmic reticulum membrane fusion
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0019888	molecular_function	protein phosphatase regulator activity
D	0030894	cellular_component	replisome
D	0030970	biological_process	retrograde protein transport, ER to cytosol
D	0031134	biological_process	sister chromatid biorientation
D	0031593	molecular_function	polyubiquitin modification-dependent protein binding
D	0032984	biological_process	protein-containing complex disassembly
D	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
D	0034517	biological_process	ribophagy
D	0034727	biological_process	piecemeal microautophagy of the nucleus
D	0036266	cellular_component	Cdc48p-Npl4p-Vms1p AAA ATPase complex
D	0036503	biological_process	ERAD pathway
D	0042802	molecular_function	identical protein binding
D	0043130	molecular_function	ubiquitin binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043328	biological_process	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
D	0043332	cellular_component	mating projection tip
D	0046034	biological_process	ATP metabolic process
D	0051228	biological_process	mitotic spindle disassembly
D	0061775	molecular_function	cohesin loader activity
D	0070651	biological_process	nonfunctional rRNA decay
D	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
D	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
D	0072344	biological_process	rescue of stalled ribosome
D	0072671	biological_process	mitochondria-associated ubiquitin-dependent protein catabolic process
D	0097352	biological_process	autophagosome maturation
D	0099638	biological_process	endosome to plasma membrane protein transport
D	0120174	biological_process	stress-induced homeostatically regulated protein degradation pathway
D	0140584	molecular_function	chromatin extrusion motor activity
D	0140588	biological_process	chromatin looping
D	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
D	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
D	1900182	biological_process	positive regulation of protein localization to nucleus
D	1902979	biological_process	mitotic DNA replication termination
D	1990112	cellular_component	RQC complex
D	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
D	1990171	biological_process	SCF complex disassembly in response to cadmium stress
E	0000837	cellular_component	Doa10p ubiquitin ligase complex
E	0000839	cellular_component	Hrd1p ubiquitin ligase ERAD-L complex
E	0003689	molecular_function	DNA clamp loader activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0006274	biological_process	DNA replication termination
E	0006338	biological_process	chromatin remodeling
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0010636	biological_process	positive regulation of mitochondrial fusion
E	0015031	biological_process	protein transport
E	0016236	biological_process	macroautophagy
E	0016320	biological_process	endoplasmic reticulum membrane fusion
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019888	molecular_function	protein phosphatase regulator activity
E	0030894	cellular_component	replisome
E	0030970	biological_process	retrograde protein transport, ER to cytosol
E	0031134	biological_process	sister chromatid biorientation
E	0031593	molecular_function	polyubiquitin modification-dependent protein binding
E	0032984	biological_process	protein-containing complex disassembly
E	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
E	0034517	biological_process	ribophagy
E	0034727	biological_process	piecemeal microautophagy of the nucleus
E	0036266	cellular_component	Cdc48p-Npl4p-Vms1p AAA ATPase complex
E	0036503	biological_process	ERAD pathway
E	0042802	molecular_function	identical protein binding
E	0043130	molecular_function	ubiquitin binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043328	biological_process	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
E	0043332	cellular_component	mating projection tip
E	0046034	biological_process	ATP metabolic process
E	0051228	biological_process	mitotic spindle disassembly
E	0061775	molecular_function	cohesin loader activity
E	0070651	biological_process	nonfunctional rRNA decay
E	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
E	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
E	0072344	biological_process	rescue of stalled ribosome
E	0072671	biological_process	mitochondria-associated ubiquitin-dependent protein catabolic process
E	0097352	biological_process	autophagosome maturation
E	0099638	biological_process	endosome to plasma membrane protein transport
E	0120174	biological_process	stress-induced homeostatically regulated protein degradation pathway
E	0140584	molecular_function	chromatin extrusion motor activity
E	0140588	biological_process	chromatin looping
E	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
E	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
E	1900182	biological_process	positive regulation of protein localization to nucleus
E	1902979	biological_process	mitotic DNA replication termination
E	1990112	cellular_component	RQC complex
E	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
E	1990171	biological_process	SCF complex disassembly in response to cadmium stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ADP A 901

Chain	Residue
A	GLY490
A	LEU698
A	BEF902
A	MG903
B	ASP619
B	ARG645
A	GLY531
A	THR532
A	GLY533
A	LYS534
A	THR535
A	LEU536
A	ILE666
A	GLN670

---

site_id	AC2
Number of Residues	8
Details	binding site for residue BEF A 902

Chain	Residue
A	PRO530
A	LYS534
A	THR535
A	ASN634
A	ADP901
A	MG903
B	ARG645
B	ARG648

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 903

Chain	Residue
A	THR535
A	ADP901
A	BEF902

---

site_id	AC4
Number of Residues	13
Details	binding site for residue ADP A 904

Chain	Residue
A	ASP215
A	GLY217
A	GLY258
A	THR259
A	GLY260
A	LYS261
A	THR262
A	LEU263
A	HIS394
A	GLY418
A	BEF905
A	MG906
B	ASP343

---

site_id	AC5
Number of Residues	8
Details	binding site for residue BEF A 905

Chain	Residue
A	PRO256
A	PRO257
A	GLY258
A	THR259
A	LYS261
A	ADP904
A	MG906
B	ARG369

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG A 906

Chain	Residue
A	THR262
A	ADP904
A	BEF905

---

site_id	AC7
Number of Residues	14
Details	binding site for residue ADP B 901

Chain	Residue
B	GLY490
B	GLY531
B	THR532
B	GLY533
B	LYS534
B	THR535
B	LEU536
B	ILE666
B	GLN670
B	LEU698
B	MG902
C	ASP619
C	ARG645
C	BEF901

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG B 902

Chain	Residue
B	THR535
B	ASP587
B	ADP901
C	BEF901

---

site_id	AC9
Number of Residues	13
Details	binding site for residue ADP B 903

Chain	Residue
B	ASP215
B	GLY258
B	THR259
B	GLY260
B	LYS261
B	THR262
B	LEU263
B	HIS394
B	GLY418
B	ALA419
B	BEF904
B	MG905
C	ASP343

---

site_id	AD1
Number of Residues	8
Details	binding site for residue BEF B 904

Chain	Residue
B	PRO257
B	GLY258
B	LYS261
B	THR262
B	ASN358
B	ADP903
B	MG905
C	ARG369

---

site_id	AD2
Number of Residues	3
Details	binding site for residue MG B 905

Chain	Residue
B	THR262
B	ADP903
B	BEF904

---

site_id	AD3
Number of Residues	7
Details	binding site for residue BEF C 901

Chain	Residue
B	PRO530
B	GLU588
B	ASN634
B	ADP901
B	MG902
C	ARG645
C	ARG648

---

site_id	AD4
Number of Residues	14
Details	binding site for residue ADP C 902

Chain	Residue
C	THR532
C	GLY533
C	LYS534
C	THR535
C	LEU536
C	ILE666
C	GLN670
C	GLY694
C	LEU698
C	BEF903
C	MG904
D	ASP619
D	ARG645
C	GLY531

---

site_id	AD5
Number of Residues	7
Details	binding site for residue BEF C 903

Chain	Residue
C	PRO530
C	LYS534
C	THR535
C	ADP902
C	MG904
D	ARG645
D	ARG648

---

site_id	AD6
Number of Residues	3
Details	binding site for residue MG C 904

Chain	Residue
C	THR535
C	ADP902
C	BEF903

---

site_id	AD7
Number of Residues	14
Details	binding site for residue ADP C 905

Chain	Residue
C	ASP215
C	GLY258
C	THR259
C	GLY260
C	LYS261
C	THR262
C	LEU263
C	VAL390
C	HIS394
C	GLY418
C	ALA419
C	BEF906
C	MG907
D	ASP343

---

site_id	AD8
Number of Residues	8
Details	binding site for residue BEF C 906

Chain	Residue
C	PRO257
C	GLY258
C	LYS261
C	THR262
C	ASN358
C	ADP905
C	MG907
D	ARG372

---

site_id	AD9
Number of Residues	4
Details	binding site for residue MG C 907

Chain	Residue
C	THR262
C	ASP314
C	ADP905
C	BEF906

---

site_id	AE1
Number of Residues	15
Details	binding site for residue ADP D 901

Chain	Residue
D	VAL489
D	GLY490
D	GLY531
D	THR532
D	GLY533
D	LYS534
D	THR535
D	LEU536
D	ILE666
D	GLN670
D	LEU698
D	BEF902
D	MG903
E	ASP619
E	ARG645

---

site_id	AE2
Number of Residues	5
Details	binding site for residue BEF D 902

Chain	Residue
D	PRO530
D	THR535
D	ADP901
D	MG903
E	ARG648

---

site_id	AE3
Number of Residues	3
Details	binding site for residue MG D 903

Chain	Residue
D	THR535
D	ADP901
D	BEF902

---

site_id	AE4
Number of Residues	15
Details	binding site for residue ADP D 904

Chain	Residue
D	ASP215
D	GLY258
D	THR259
D	GLY260
D	LYS261
D	THR262
D	LEU263
D	HIS394
D	GLY418
D	ALA419
D	BEF905
D	MG906
E	ASP343
E	ARG369
E	ARG372

---

site_id	AE5
Number of Residues	7
Details	binding site for residue BEF D 905

Chain	Residue
D	PRO256
D	PRO257
D	GLY258
D	LYS261
D	ASN358
D	ADP904
D	MG906

---

site_id	AE6
Number of Residues	3
Details	binding site for residue MG D 906

Chain	Residue
D	THR262
D	ADP904
D	BEF905

---

site_id	AE7
Number of Residues	13
Details	binding site for residue ADP E 901

Chain	Residue
E	ASP488
E	GLY490
E	PRO530
E	GLY531
E	THR532
E	GLY533
E	LYS534
E	THR535
E	ILE666
E	GLN670
E	GLY694
E	ALA695
E	LEU698

---

site_id	AE8
Number of Residues	9
Details	binding site for residue ADP E 902

Chain	Residue
E	ASP215
E	GLY217
E	GLY258
E	THR259
E	GLY260
E	THR262
E	LEU263
E	HIS394
E	ALA419

---

Functional Information from PROSITE/UniProt

site_id	PS00430
Number of Residues	72
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mgeehkplldasgvdpreedktatailrrkkkdnmllvddainddnsviainsntmdklelfrg...................................................DTVLVKGK

Chain	Residue	Details
A	MET1-LYS72

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VvVIaATNrpnsIDpALr.R

Chain	Residue	Details
A	VAL351-ARG369
A	VAL627-ARG645

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P55072

Chain	Residue	Details
A	PRO257
D	PRO257
D	ASN358
D	HIS394
E	PRO257
E	ASN358
E	HIS394
A	ASN358
A	HIS394
B	PRO257
B	ASN358
B	HIS394
C	PRO257
C	ASN358
C	HIS394

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	GLY531
B	GLY531
C	GLY531
D	GLY531
E	GLY531

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER472
B	SER472
C	SER472
D	SER472
E	SER472

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER519
B	SER519
C	SER519
D	SER519
E	SER519

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	THR735
B	THR735
C	THR735
D	THR735
E	THR735

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950

Chain	Residue	Details
A	SER770
B	SER770
C	SER770
D	SER770
E	SER770

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS305
B	LYS539
C	LYS305
C	LYS322
C	LYS346
C	LYS522
C	LYS539
D	LYS305
D	LYS322
D	LYS346
D	LYS522
A	LYS322
D	LYS539
E	LYS305
E	LYS322
E	LYS346
E	LYS522
E	LYS539
A	LYS346
A	LYS522
A	LYS539
B	LYS305
B	LYS322
B	LYS346
B	LYS522

---

site_id	SWS_FT_FI8
Number of Residues	15
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12872131

Chain	Residue	Details
D	LYS594
D	LYS673
E	LYS594
E	LYS673
A	LYS594
A	LYS673
B	LYS594
B	LYS673
C	LYS594
C	LYS673

---