6OKC
Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C12-crypto Acyl Carrier Protein, AcpP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
A | 0044281 | biological_process | small molecule metabolic process |
A | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006633 | biological_process | fatty acid biosynthetic process |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
B | 0044281 | biological_process | small molecule metabolic process |
B | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
C | 0000035 | molecular_function | acyl binding |
C | 0000036 | molecular_function | acyl carrier activity |
C | 0005515 | molecular_function | protein binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006633 | biological_process | fatty acid biosynthetic process |
C | 0008289 | molecular_function | lipid binding |
C | 0008610 | biological_process | lipid biosynthetic process |
C | 0009245 | biological_process | lipid A biosynthetic process |
C | 0009410 | biological_process | response to xenobiotic stimulus |
C | 0031177 | molecular_function | phosphopantetheine binding |
D | 0000035 | molecular_function | acyl binding |
D | 0000036 | molecular_function | acyl carrier activity |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006633 | biological_process | fatty acid biosynthetic process |
D | 0008289 | molecular_function | lipid binding |
D | 0008610 | biological_process | lipid biosynthetic process |
D | 0009245 | biological_process | lipid A biosynthetic process |
D | 0009410 | biological_process | response to xenobiotic stimulus |
D | 0031177 | molecular_function | phosphopantetheine binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | binding site for Di-peptide MRJ A 501 and SER D 36 |
Chain | Residue |
A | THR34 |
A | GLY107 |
A | ALA162 |
A | CYS163 |
A | MET197 |
A | GLU200 |
A | PHE201 |
A | VAL270 |
A | THR300 |
A | THR302 |
A | VAL304 |
A | PHE35 |
A | PHE390 |
A | GLY391 |
A | PHE392 |
A | HOH603 |
A | HOH620 |
A | HOH751 |
A | HOH784 |
B | GLN113 |
D | ASP35 |
D | LEU37 |
A | GLN37 |
D | ASP38 |
D | THR39 |
D | VAL40 |
D | HOH133 |
A | GLU38 |
A | LEU39 |
A | LYS40 |
A | HIS47 |
A | TRP49 |
A | GLY106 |
site_id | AC2 |
Number of Residues | 33 |
Details | binding site for Di-peptide MRJ A 501 and SER D 36 |
Chain | Residue |
A | THR34 |
A | PHE35 |
A | GLN37 |
A | GLU38 |
A | LEU39 |
A | LYS40 |
A | HIS47 |
A | TRP49 |
A | GLY106 |
A | GLY107 |
A | ALA162 |
A | CYS163 |
A | MET197 |
A | GLU200 |
A | PHE201 |
A | VAL270 |
A | THR300 |
A | THR302 |
A | VAL304 |
A | PHE390 |
A | GLY391 |
A | PHE392 |
A | HOH603 |
A | HOH620 |
A | HOH751 |
A | HOH784 |
B | GLN113 |
D | ASP35 |
D | LEU37 |
D | ASP38 |
D | THR39 |
D | VAL40 |
D | HOH133 |
site_id | AC3 |
Number of Residues | 31 |
Details | binding site for Di-peptide MRJ B 501 and SER C 36 |
Chain | Residue |
A | GLN113 |
A | MET138 |
B | THR34 |
B | PHE35 |
B | GLN37 |
B | GLU38 |
B | LEU39 |
B | LYS40 |
B | HIS47 |
B | TRP49 |
B | GLY106 |
B | ALA162 |
B | CYS163 |
B | MET197 |
B | GLU200 |
B | PHE201 |
B | VAL270 |
B | THR300 |
B | THR302 |
B | PHE390 |
B | GLY391 |
B | PHE392 |
B | HOH605 |
B | HOH621 |
B | HOH748 |
C | ASP35 |
C | LEU37 |
C | ASP38 |
C | THR39 |
C | VAL40 |
C | HOH212 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258, ECO:0000269|PubMed:4882207 |
Chain | Residue | Details |
C | SER36 | |
D | SER36 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
Chain | Residue | Details |
A | HIS298 | |
A | HIS333 | |
B | HIS298 | |
B | HIS333 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 292 |
Chain | Residue | Details |
A | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
A | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | LYS328 | activator, hydrogen bond donor |
A | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
A | PHE390 | activator, hydrogen bond acceptor |
A | PHE392 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 6 |
Details | M-CSA 292 |
Chain | Residue | Details |
B | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
B | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | LYS328 | activator, hydrogen bond donor |
B | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
B | PHE390 | activator, hydrogen bond acceptor |
B | PHE392 | electrostatic stabiliser, hydrogen bond donor |