Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6OIW

Structure of Escherichia coli dGTPase bound to dGTP-1-thiol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003697	molecular_function	single-stranded DNA binding
A	0003924	molecular_function	GTPase activity
A	0006203	biological_process	dGTP catabolic process
A	0008832	molecular_function	dGTPase activity
A	0015949	biological_process	nucleobase-containing small molecule interconversion
A	0016787	molecular_function	hydrolase activity
A	0016793	molecular_function	triphosphoric monoester hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0042802	molecular_function	identical protein binding
A	0043099	biological_process	pyrimidine deoxyribonucleoside salvage
A	0050897	molecular_function	cobalt ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003697	molecular_function	single-stranded DNA binding
B	0003924	molecular_function	GTPase activity
B	0006203	biological_process	dGTP catabolic process
B	0008832	molecular_function	dGTPase activity
B	0015949	biological_process	nucleobase-containing small molecule interconversion
B	0016787	molecular_function	hydrolase activity
B	0016793	molecular_function	triphosphoric monoester hydrolase activity
B	0030145	molecular_function	manganese ion binding
B	0042802	molecular_function	identical protein binding
B	0043099	biological_process	pyrimidine deoxyribonucleoside salvage
B	0050897	molecular_function	cobalt ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003697	molecular_function	single-stranded DNA binding
C	0003924	molecular_function	GTPase activity
C	0006203	biological_process	dGTP catabolic process
C	0008832	molecular_function	dGTPase activity
C	0015949	biological_process	nucleobase-containing small molecule interconversion
C	0016787	molecular_function	hydrolase activity
C	0016793	molecular_function	triphosphoric monoester hydrolase activity
C	0030145	molecular_function	manganese ion binding
C	0042802	molecular_function	identical protein binding
C	0043099	biological_process	pyrimidine deoxyribonucleoside salvage
C	0050897	molecular_function	cobalt ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003697	molecular_function	single-stranded DNA binding
D	0003924	molecular_function	GTPase activity
D	0006203	biological_process	dGTP catabolic process
D	0008832	molecular_function	dGTPase activity
D	0015949	biological_process	nucleobase-containing small molecule interconversion
D	0016787	molecular_function	hydrolase activity
D	0016793	molecular_function	triphosphoric monoester hydrolase activity
D	0030145	molecular_function	manganese ion binding
D	0042802	molecular_function	identical protein binding
D	0043099	biological_process	pyrimidine deoxyribonucleoside salvage
D	0050897	molecular_function	cobalt ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003697	molecular_function	single-stranded DNA binding
E	0003924	molecular_function	GTPase activity
E	0006203	biological_process	dGTP catabolic process
E	0008832	molecular_function	dGTPase activity
E	0015949	biological_process	nucleobase-containing small molecule interconversion
E	0016787	molecular_function	hydrolase activity
E	0016793	molecular_function	triphosphoric monoester hydrolase activity
E	0030145	molecular_function	manganese ion binding
E	0042802	molecular_function	identical protein binding
E	0043099	biological_process	pyrimidine deoxyribonucleoside salvage
E	0050897	molecular_function	cobalt ion binding
F	0000287	molecular_function	magnesium ion binding
F	0003697	molecular_function	single-stranded DNA binding
F	0003924	molecular_function	GTPase activity
F	0006203	biological_process	dGTP catabolic process
F	0008832	molecular_function	dGTPase activity
F	0015949	biological_process	nucleobase-containing small molecule interconversion
F	0016787	molecular_function	hydrolase activity
F	0016793	molecular_function	triphosphoric monoester hydrolase activity
F	0030145	molecular_function	manganese ion binding
F	0042802	molecular_function	identical protein binding
F	0043099	biological_process	pyrimidine deoxyribonucleoside salvage
F	0050897	molecular_function	cobalt ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 601

Chain	Residue
A	LYS211
A	ASP268
A	ASP269
A	T8T603

site_id	AC2
Number of Residues	4
Details	binding site for residue MN A 602

Chain	Residue
A	HIS69
A	HIS117
A	ASP118
A	ASP268

site_id	AC3
Number of Residues	16
Details	binding site for residue T8T A 603

Chain	Residue
A	VAL54
A	HIS126
A	ASN186
A	LYS211
A	TYR212
A	LYS232
A	ASP268
A	ASP269
A	TYR272
A	ASP276
A	PHE391
A	VAL396
A	GLU400
A	MG601
A	HOH702
A	GLN53

site_id	AC4
Number of Residues	5
Details	binding site for residue MN B 601

Chain	Residue
B	HIS69
B	HIS117
B	ASP118
B	ASP268
B	T8T602

site_id	AC5
Number of Residues	14
Details	binding site for residue T8T B 602

Chain	Residue
B	GLN53
B	VAL54
B	ASP118
B	HIS126
B	LYS211
B	LYS232
B	ASP268
B	TYR272
B	ASP276
B	PHE391
B	VAL396
B	GLU400
B	MN601
C	ARG433

site_id	AC6
Number of Residues	4
Details	binding site for residue MN C 601

Chain	Residue
C	HIS69
C	HIS117
C	ASP118
C	ASP268

site_id	AC7
Number of Residues	14
Details	binding site for residue T8T C 602

Chain	Residue
A	ARG442
C	GLN53
C	VAL54
C	HIS126
C	LYS211
C	TYR212
C	LYS232
C	ASP268
C	ASP269
C	TYR272
C	ASP276
C	VAL396
C	GLU400
C	HOH701

site_id	AC8
Number of Residues	5
Details	binding site for residue MN D 601

Chain	Residue
D	HIS69
D	HIS117
D	ASP118
D	ASP268
D	T8T602

site_id	AC9
Number of Residues	15
Details	binding site for residue T8T D 602

Chain	Residue
D	VAL54
D	ASP118
D	HIS126
D	ASN186
D	LYS211
D	TYR212
D	LYS232
D	ASP268
D	TYR272
D	ASP276
D	VAL396
D	GLU400
D	MN601
D	HOH701
F	ARG442

site_id	AD1
Number of Residues	4
Details	binding site for residue MG E 601

Chain	Residue
E	ASP268
E	ASP269
E	TYR272
E	T8T603

site_id	AD2
Number of Residues	5
Details	binding site for residue MN E 602

Chain	Residue
E	HIS69
E	HIS117
E	ASP118
E	ASP268
E	T8T603

site_id	AD3
Number of Residues	18
Details	binding site for residue T8T E 603

Chain	Residue
E	TYR212
E	LYS232
E	ASP268
E	TYR272
E	ASP276
E	VAL396
E	GLU400
E	MG601
E	MN602
D	ARG433
D	ARG442
E	GLN53
E	VAL54
E	HIS117
E	ASP118
E	HIS126
E	ASN186
E	LYS211

site_id	AD4
Number of Residues	3
Details	binding site for residue MG F 601

Chain	Residue
F	ASP268
F	ASP269
F	T8T603

site_id	AD5
Number of Residues	5
Details	binding site for residue MN F 602

Chain	Residue
F	HIS69
F	HIS117
F	ASP118
F	ASP268
F	T8T603

site_id	AD6
Number of Residues	14
Details	binding site for residue T8T F 603

Chain	Residue
E	ARG442
F	GLN53
F	VAL54
F	HIS126
F	ASN186
F	LYS211
F	TYR212
F	LYS232
F	TYR272
F	ASP276
F	VAL396
F	GLU400
F	MG601
F	MN602

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1242
Details	Domain: {"description":"HD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 966

Chain	Residue	Details
A	HIS69	metal ligand
A	HIS117	metal ligand
A	ASP118	metal ligand
A	ASP268	metal ligand
A	ARG442	unknown

site_id	MCSA2
Number of Residues	5
Details	M-CSA 966

Chain	Residue	Details
B	HIS69	metal ligand
B	HIS117	metal ligand
B	ASP118	metal ligand
B	ASP268	metal ligand
B	ARG442	unknown

site_id	MCSA3
Number of Residues	5
Details	M-CSA 966

Chain	Residue	Details
C	HIS69	metal ligand
C	HIS117	metal ligand
C	ASP118	metal ligand
C	ASP268	metal ligand
C	ARG442	unknown

site_id	MCSA4
Number of Residues	5
Details	M-CSA 966

Chain	Residue	Details
D	HIS69	metal ligand
D	HIS117	metal ligand
D	ASP118	metal ligand
D	ASP268	metal ligand
D	ARG442	unknown

site_id	MCSA5
Number of Residues	5
Details	M-CSA 966

Chain	Residue	Details
E	HIS69	metal ligand
E	HIS117	metal ligand
E	ASP118	metal ligand
E	ASP268	metal ligand
E	ARG442	unknown

site_id	MCSA6
Number of Residues	5
Details	M-CSA 966

Chain	Residue	Details
F	HIS69	metal ligand
F	HIS117	metal ligand
F	ASP118	metal ligand
F	ASP268	metal ligand
F	ARG442	unknown

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)