6OIC
Crystal structure of human Sulfide Quinone Oxidoreductase in complex with coenzyme Q (sulfite soaked)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0048038 | molecular_function | quinone binding |
A | 0070221 | biological_process | sulfide oxidation, using sulfide:quinone oxidoreductase |
A | 0070224 | molecular_function | sulfide:quinone oxidoreductase activity |
A | 0071949 | molecular_function | FAD binding |
A | 0106436 | molecular_function | glutathione-dependent sulfide quinone oxidoreductase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0048038 | molecular_function | quinone binding |
B | 0070221 | biological_process | sulfide oxidation, using sulfide:quinone oxidoreductase |
B | 0070224 | molecular_function | sulfide:quinone oxidoreductase activity |
B | 0071949 | molecular_function | FAD binding |
B | 0106436 | molecular_function | glutathione-dependent sulfide quinone oxidoreductase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 36 |
Details | binding site for residue FAD A 501 |
Chain | Residue |
A | GLY50 |
A | VAL118 |
A | ALA144 |
A | LEU145 |
A | GLY146 |
A | ASN169 |
A | TYR170 |
A | CYS201 |
A | LYS207 |
A | VAL303 |
A | GLY335 |
A | GLY52 |
A | ASP336 |
A | LYS344 |
A | THR345 |
A | ALA346 |
A | ALA347 |
A | VAL349 |
A | PRO380 |
A | LYS418 |
A | UQ1503 |
A | H2S505 |
A | SER53 |
A | HOH602 |
A | HOH603 |
A | HOH610 |
A | HOH620 |
A | HOH624 |
A | HOH629 |
A | HOH649 |
A | GLY54 |
A | GLU75 |
A | PRO76 |
A | GLN83 |
A | PRO84 |
A | ARG117 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue UQ1 A 502 |
Chain | Residue |
A | GLN247 |
A | GLN251 |
A | LEU255 |
A | THR256 |
A | VAL257 |
A | TYR259 |
site_id | AC3 |
Number of Residues | 13 |
Details | binding site for residue UQ1 A 503 |
Chain | Residue |
A | TYR82 |
A | ALA346 |
A | ALA347 |
A | TYR376 |
A | SER378 |
A | LEU390 |
A | GLU392 |
A | THR402 |
A | MET422 |
A | MET430 |
A | TRP435 |
A | PRO438 |
A | FAD501 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue UQ1 A 504 |
Chain | Residue |
A | LYS371 |
A | TYR434 |
A | TRP435 |
A | GLY436 |
A | GLY437 |
A | PHE440 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue H2S A 505 |
Chain | Residue |
A | CYS201 |
A | THR345 |
A | CYS379 |
A | FAD501 |
site_id | AC6 |
Number of Residues | 32 |
Details | binding site for residue FAD B 501 |
Chain | Residue |
B | GLY50 |
B | GLY52 |
B | SER53 |
B | GLY54 |
B | GLU75 |
B | PRO76 |
B | GLN83 |
B | PRO84 |
B | THR87 |
B | ARG117 |
B | VAL118 |
B | ALA144 |
B | LEU145 |
B | GLY146 |
B | ASN169 |
B | TYR170 |
B | CYS201 |
B | LYS207 |
B | VAL303 |
B | GLY335 |
B | ASP336 |
B | LYS344 |
B | THR345 |
B | ALA346 |
B | ALA347 |
B | PRO380 |
B | LYS418 |
B | UQ1502 |
B | H2S503 |
B | HOH609 |
B | HOH611 |
B | HOH612 |
site_id | AC7 |
Number of Residues | 14 |
Details | binding site for residue UQ1 B 502 |
Chain | Residue |
B | ALA347 |
B | TYR376 |
B | SER378 |
B | PRO380 |
B | LEU390 |
B | GLU392 |
B | THR402 |
B | MET422 |
B | MET430 |
B | TRP435 |
B | PRO438 |
B | FAD501 |
B | TYR82 |
B | ALA346 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000269|PubMed:30905673, ECO:0000303|PubMed:22852582 |
Chain | Residue | Details |
A | CYS201 | |
A | CYS379 | |
B | CYS201 | |
B | CYS379 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30905673 |
Chain | Residue | Details |
A | SER53 | |
B | VAL118 | |
B | ASP336 | |
B | LYS344 | |
A | GLU75 | |
A | GLN83 | |
A | VAL118 | |
A | ASP336 | |
A | LYS344 | |
B | SER53 | |
B | GLU75 | |
B | GLN83 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9R112 |
Chain | Residue | Details |
A | LYS173 | |
B | LYS173 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R112 |
Chain | Residue | Details |
A | SER343 | |
B | SER343 |