6OIA
(1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004587 | molecular_function | ornithine aminotransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0007601 | biological_process | visual perception |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0010121 | biological_process | L-arginine catabolic process to proline via ornithine |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019544 | biological_process | L-arginine catabolic process to L-glutamate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0055129 | biological_process | L-proline biosynthetic process |
| B | 0004587 | molecular_function | ornithine aminotransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0007601 | biological_process | visual perception |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0010121 | biological_process | L-arginine catabolic process to proline via ornithine |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019544 | biological_process | L-arginine catabolic process to L-glutamate |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0055129 | biological_process | L-proline biosynthetic process |
| C | 0004587 | molecular_function | ornithine aminotransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0007601 | biological_process | visual perception |
| C | 0008483 | molecular_function | transaminase activity |
| C | 0010121 | biological_process | L-arginine catabolic process to proline via ornithine |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019544 | biological_process | L-arginine catabolic process to L-glutamate |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0055129 | biological_process | L-proline biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue PLP A 501 |
| Chain | Residue |
| A | GLY142 |
| A | HOH674 |
| A | HOH739 |
| B | THR322 |
| B | HOH642 |
| A | VAL143 |
| A | PHE177 |
| A | TRP178 |
| A | ASP263 |
| A | ILE265 |
| A | GLN266 |
| A | LYS292 |
| A | HOH627 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | TYR166 |
| A | LYS167 |
| A | PRO202 |
| A | HOH711 |
| A | HOH734 |
| A | HOH750 |
| A | HOH761 |
| A | HOH765 |
| C | GLN220 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue PLP B 501 |
| Chain | Residue |
| A | THR322 |
| A | HOH608 |
| B | THR141 |
| B | GLY142 |
| B | VAL143 |
| B | PHE177 |
| B | TRP178 |
| B | ASP263 |
| B | ILE265 |
| B | GLN266 |
| B | LYS292 |
| B | MQ4503 |
| B | HOH687 |
| B | HOH752 |
| B | HOH799 |
| B | HOH845 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | ILE206 |
| B | ILE207 |
| B | HOH608 |
| B | HOH883 |
| C | THR189 |
| C | PRO208 |
| C | HOH764 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide MQ4 B 503 and LYS B 292 |
| Chain | Residue |
| A | SER321 |
| A | THR322 |
| A | TYR323 |
| B | TYR55 |
| B | TYR85 |
| B | PHE177 |
| B | GLU235 |
| B | ILE265 |
| B | GLN266 |
| B | GLY291 |
| B | ALA293 |
| B | LEU294 |
| B | SER295 |
| B | ARG413 |
| B | PLP501 |
| B | HOH604 |
| B | HOH656 |
| B | HOH673 |
| B | HOH792 |
| B | HOH799 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | binding site for residues PLP C 501 and MQ4 C 502 |
| Chain | Residue |
| C | TYR55 |
| C | TYR85 |
| C | THR141 |
| C | GLY142 |
| C | VAL143 |
| C | PHE177 |
| C | TRP178 |
| C | GLU235 |
| C | ASP263 |
| C | ILE265 |
| C | GLN266 |
| C | LYS292 |
| C | SER321 |
| C | THR322 |
| C | ARG413 |
| C | HOH625 |
| C | HOH654 |
| C | HOH662 |
| C | HOH677 |
| C | HOH740 |
| C | HOH770 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide MQ4 C 502 and LYS C 292 |
| Chain | Residue |
| C | TYR323 |
| C | ARG413 |
| C | PLP501 |
| C | HOH662 |
| C | HOH711 |
| C | HOH740 |
| C | HOH770 |
| C | TYR55 |
| C | TYR85 |
| C | ALA87 |
| C | PHE177 |
| C | GLU235 |
| C | ILE265 |
| C | GLN266 |
| C | GLY291 |
| C | ALA293 |
| C | LEU294 |
| C | SER295 |
| C | SER321 |
| C | THR322 |
Functional Information from PROSITE/UniProt
| site_id | PS00600 |
| Number of Residues | 38 |
| Details | AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. FIaDEIqt.GLaRtGrwlavdyenvrp....DIVllGKalsGG |
| Chain | Residue | Details |
| A | PHE260-GLY297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P29758","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P29758","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P29758","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"3754226","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 929 |
| Chain | Residue | Details |
| A | PHE177 | steric role |
| A | ASP263 | electrostatic stabiliser |
| A | LYS292 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 929 |
| Chain | Residue | Details |
| B | PHE177 | steric role |
| B | ASP263 | electrostatic stabiliser |
| B | LYS292 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 929 |
| Chain | Residue | Details |
| C | PHE177 | steric role |
| C | ASP263 | electrostatic stabiliser |
| C | LYS292 | covalent catalysis, proton shuttle (general acid/base) |
