6OH3

X-ray crystal structure of the mouse CMP-sialic acid transporter in complex with CMP-sialic acid, by lipidic cubic phase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005456	molecular_function	CMP-N-acetylneuraminate transmembrane transporter activity
A	0005794	cellular_component	Golgi apparatus
A	0015165	molecular_function	pyrimidine nucleotide-sugar transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015782	biological_process	CMP-N-acetylneuraminate transmembrane transport
A	0016020	cellular_component	membrane
A	0071702	biological_process	organic substance transport
A	0090481	biological_process	pyrimidine nucleotide-sugar transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue NCC A 401

Chain	Residue
A	ALA24
A	SER188
A	PHE195
A	ASN210
A	TYR214
A	GLY257
A	THR260
A	SER261
A	LYS272
A	HOH501
A	TYR27
A	LYS55
A	TYR98
A	GLN101
A	ASN102
A	TYR117
A	TYR121
A	LYS124

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10085119, ECO:0000269|PubMed:30985278

Chain	Residue	Details
A	MET1-SER9

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site_id	SWS_FT_FI2
Number of Residues	188
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30985278

Chain	Residue	Details
A	LEU10-ALA30
A	LEU297-LEU315
A	THR46-ALA64
A	LEU88-ALA108
A	ALA115-MET135
A	LYS142-TRP160
A	LEU176-GLU196
A	ASN210-SER228
A	TYR244-VAL262
A	ILE270-VAL288

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site_id	SWS_FT_FI3
Number of Residues	54
Details	TOPO_DOM: Lumenal => ECO:0000269|PubMed:30985278

Chain	Residue	Details
A	LEU31-THR45
A	LEU109-ALA114
A	LYS161-LEU175
A	ASP229-THR243
A	LEU289-THR296

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site_id	SWS_FT_FI4
Number of Residues	45
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30985278

Chain	Residue	Details
A	LYS65-GLU87
A	LEU136-SER141
A	LYS197-ARG209
A	VAL263-ASN269

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site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:30985278, ECO:0007744|PDB:6OH2, ECO:0007744|PDB:6OH3

Chain	Residue	Details
A	LYS55
A	GLN101
A	TYR117
A	SER188
A	ASN210
A	LYS272

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