6OF8

Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004683	molecular_function	calmodulin-dependent protein kinase activity
A	0005516	molecular_function	calmodulin binding
A	0006468	biological_process	protein phosphorylation
B	0004683	molecular_function	calmodulin-dependent protein kinase activity
B	0005516	molecular_function	calmodulin binding
B	0006468	biological_process	protein phosphorylation
C	0004683	molecular_function	calmodulin-dependent protein kinase activity
C	0005516	molecular_function	calmodulin binding
C	0006468	biological_process	protein phosphorylation
D	0004683	molecular_function	calmodulin-dependent protein kinase activity
D	0005516	molecular_function	calmodulin binding
D	0006468	biological_process	protein phosphorylation
E	0004683	molecular_function	calmodulin-dependent protein kinase activity
E	0005516	molecular_function	calmodulin binding
E	0006468	biological_process	protein phosphorylation
F	0004683	molecular_function	calmodulin-dependent protein kinase activity
F	0005516	molecular_function	calmodulin binding
F	0006468	biological_process	protein phosphorylation
G	0004683	molecular_function	calmodulin-dependent protein kinase activity
G	0005516	molecular_function	calmodulin binding
G	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue K F 501

Chain	Residue
D	GLN348
F	THR370
F	LYS371
F	CYS373
F	GLN463

---

site_id	AC2
Number of Residues	4
Details	binding site for residue K F 502

Chain	Residue
F	MET377
F	ALA379
F	VAL389
F	GLY391

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL C 501

Chain	Residue
C	GLN448
D	LEU385
D	GLY386
D	ASN387
E	LEU385
E	GLY386
E	ASN387
F	GLN448

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL E 501

Chain	Residue
E	GLN448
F	LEU385
F	ASN387
G	GLN448

---

site_id	AC5
Number of Residues	4
Details	binding site for residue K E 502

Chain	Residue
E	THR370
E	LYS371
E	CYS373
E	GLN463

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 501

Chain	Residue
A	LEU385
A	GLY386
A	ASN387
B	ILE432
B	GLN448

---

site_id	AC7
Number of Residues	4
Details	binding site for residue K A 502

Chain	Residue
A	THR370
A	LYS371
A	CYS373
A	GLN463

---

site_id	AC8
Number of Residues	4
Details	binding site for residue K D 501

Chain	Residue
D	THR370
D	LYS371
D	CYS373
D	GLN463

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11798

Chain	Residue	Details
F	SER404
B	SER404
C	SER404
G	SER404
E	SER404
A	SER404
D	SER404

---