6OF0

Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0006351	biological_process	DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0006351	biological_process	DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0006351	biological_process	DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0006351	biological_process	DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 301

Chain	Residue
A	GLN133
A	ARG137
A	LYS167
A	HOH411
B	ARG176
B	SER180

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 B 301

Chain	Residue
B	LYS167
A	ARG176
B	GLN133
B	ARG137

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PO4 B 302

Chain	Residue
B	THR43
B	ARG44
B	HOH407
C	LYS188
C	ARG192

---

site_id	AC4
Number of Residues	2
Details	binding site for residue PO4 B 303

Chain	Residue
B	THR11
B	HIS50

---

site_id	AC5
Number of Residues	4
Details	binding site for residue PO4 C 301

Chain	Residue
C	GLN133
C	ARG137
C	LYS167
D	ARG176

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PO4 C 302

Chain	Residue
C	ARG176
D	GLN133
D	ALA134
D	LYS167

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GIartSLneIaqaagVTrGaLYwHFkNKed.L

Chain	Residue	Details
A	GLY27-LEU57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Domain: {"description":"HTH tetR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	76
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---