6OEB

Crystal structure of HMCES SRAP domain in complex with 3' overhang DNA

Replaces:  6NLD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003697	molecular_function	single-stranded DNA binding
A	0006974	biological_process	DNA damage response
A	0106300	biological_process	protein-DNA covalent cross-linking repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue EDO A 301

Chain	Residue
A	LYS37
A	ASN49
A	VAL191
A	LEU192
A	TYR193
A	EDO302
A	HOH429

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 302

Chain	Residue
A	PRO72
A	TYR193
A	EDO301
A	ASP34
A	PHE59

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 303

Chain	Residue
A	ALA17
A	CYS18
A	LEU53
A	ARG68
A	THR175
A	GLU220
A	HOH436

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 304

Chain	Residue
A	HIS8
A	PRO40
A	SER41
A	ASN262

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 305

Chain	Residue
A	ARG16
A	ASP34
A	PRO35
A	ASP36
A	HOH447

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO C 101

Chain	Residue
A	ASN93
C	DG5

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"31235913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30554877","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"37519246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37950866","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Required for sensing abasic sites","evidences":[{"source":"UniProtKB","id":"P76318","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Required to stabilize abasic sites","evidences":[{"source":"UniProtKB","id":"P76318","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Thiazolidine linkage to a ring-opened DNA abasic site","evidences":[{"source":"PubMed","id":"31235913","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---