Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

6OCX

Structure of human CIB1 in complex with peptide inhibitor UNC10245109

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001525biological_processangiogenesis
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002931biological_processresponse to ischemia
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006302biological_processdouble-strand break repair
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007026biological_processnegative regulation of microtubule depolymerization
A0007113biological_processendomitotic cell cycle
A0007155biological_processcell adhesion
A0007283biological_processspermatogenesis
A0007286biological_processspermatid development
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
A0010977biological_processnegative regulation of neuron projection development
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016604cellular_componentnuclear body
A0030027cellular_componentlamellipodium
A0030154biological_processcell differentiation
A0030220biological_processplatelet formation
A0030291molecular_functionprotein serine/threonine kinase inhibitor activity
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0031122biological_processcytoplasmic microtubule organization
A0031267molecular_functionsmall GTPase binding
A0031982cellular_componentvesicle
A0032433cellular_componentfilopodium tip
A0032587cellular_componentruffle membrane
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0038163biological_processthrombopoietin-mediated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043085biological_processpositive regulation of catalytic activity
A0043204cellular_componentperikaryon
A0043495molecular_functionmembrane-membrane adaptor activity
A0044325molecular_functiontransmembrane transporter binding
A0045653biological_processnegative regulation of megakaryocyte differentiation
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051301biological_processcell division
A0051302biological_processregulation of cell division
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0090314biological_processpositive regulation of protein targeting to membrane
A0097191biological_processextrinsic apoptotic signaling pathway
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1990090biological_processcellular response to nerve growth factor stimulus
A2000256biological_processpositive regulation of male germ cell proliferation
B0000287molecular_functionmagnesium ion binding
B0001525biological_processangiogenesis
B0001933biological_processnegative regulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0001954biological_processpositive regulation of cell-matrix adhesion
B0002931biological_processresponse to ischemia
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006302biological_processdouble-strand break repair
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007026biological_processnegative regulation of microtubule depolymerization
B0007113biological_processendomitotic cell cycle
B0007155biological_processcell adhesion
B0007283biological_processspermatogenesis
B0007286biological_processspermatid development
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
B0010977biological_processnegative regulation of neuron projection development
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016604cellular_componentnuclear body
B0030027cellular_componentlamellipodium
B0030154biological_processcell differentiation
B0030220biological_processplatelet formation
B0030291molecular_functionprotein serine/threonine kinase inhibitor activity
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0031122biological_processcytoplasmic microtubule organization
B0031267molecular_functionsmall GTPase binding
B0031982cellular_componentvesicle
B0032433cellular_componentfilopodium tip
B0032587cellular_componentruffle membrane
B0033630biological_processpositive regulation of cell adhesion mediated by integrin
B0038163biological_processthrombopoietin-mediated signaling pathway
B0042127biological_processregulation of cell population proliferation
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043066biological_processnegative regulation of apoptotic process
B0043085biological_processpositive regulation of catalytic activity
B0043204cellular_componentperikaryon
B0043495molecular_functionmembrane-membrane adaptor activity
B0044325molecular_functiontransmembrane transporter binding
B0045653biological_processnegative regulation of megakaryocyte differentiation
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051301biological_processcell division
B0051302biological_processregulation of cell division
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0070062cellular_componentextracellular exosome
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
B0071356biological_processcellular response to tumor necrosis factor
B0071363biological_processcellular response to growth factor stimulus
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0071944cellular_componentcell periphery
B0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
B0090314biological_processpositive regulation of protein targeting to membrane
B0097191biological_processextrinsic apoptotic signaling pathway
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1990090biological_processcellular response to nerve growth factor stimulus
B2000256biological_processpositive regulation of male germ cell proliferation
C0000287molecular_functionmagnesium ion binding
C0001525biological_processangiogenesis
C0001933biological_processnegative regulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0001954biological_processpositive regulation of cell-matrix adhesion
C0002931biological_processresponse to ischemia
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006302biological_processdouble-strand break repair
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007026biological_processnegative regulation of microtubule depolymerization
C0007113biological_processendomitotic cell cycle
C0007155biological_processcell adhesion
C0007283biological_processspermatogenesis
C0007286biological_processspermatid development
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
C0010977biological_processnegative regulation of neuron projection development
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0016604cellular_componentnuclear body
C0030027cellular_componentlamellipodium
C0030154biological_processcell differentiation
C0030220biological_processplatelet formation
C0030291molecular_functionprotein serine/threonine kinase inhibitor activity
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0031122biological_processcytoplasmic microtubule organization
C0031267molecular_functionsmall GTPase binding
C0031982cellular_componentvesicle
C0032433cellular_componentfilopodium tip
C0032587cellular_componentruffle membrane
C0033630biological_processpositive regulation of cell adhesion mediated by integrin
C0038163biological_processthrombopoietin-mediated signaling pathway
C0042127biological_processregulation of cell population proliferation
C0042383cellular_componentsarcolemma
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043066biological_processnegative regulation of apoptotic process
C0043085biological_processpositive regulation of catalytic activity
C0043204cellular_componentperikaryon
C0043495molecular_functionmembrane-membrane adaptor activity
C0044325molecular_functiontransmembrane transporter binding
C0045653biological_processnegative regulation of megakaryocyte differentiation
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0051301biological_processcell division
C0051302biological_processregulation of cell division
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
C0071356biological_processcellular response to tumor necrosis factor
C0071363biological_processcellular response to growth factor stimulus
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0071944cellular_componentcell periphery
C0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
C0090314biological_processpositive regulation of protein targeting to membrane
C0097191biological_processextrinsic apoptotic signaling pathway
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1903078biological_processpositive regulation of protein localization to plasma membrane
C1990090biological_processcellular response to nerve growth factor stimulus
C2000256biological_processpositive regulation of male germ cell proliferation
D0000287molecular_functionmagnesium ion binding
D0001525biological_processangiogenesis
D0001933biological_processnegative regulation of protein phosphorylation
D0001934biological_processpositive regulation of protein phosphorylation
D0001954biological_processpositive regulation of cell-matrix adhesion
D0002931biological_processresponse to ischemia
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005813cellular_componentcentrosome
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006302biological_processdouble-strand break repair
D0006915biological_processapoptotic process
D0006974biological_processDNA damage response
D0007026biological_processnegative regulation of microtubule depolymerization
D0007113biological_processendomitotic cell cycle
D0007155biological_processcell adhesion
D0007283biological_processspermatogenesis
D0007286biological_processspermatid development
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
D0010977biological_processnegative regulation of neuron projection development
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0016604cellular_componentnuclear body
D0030027cellular_componentlamellipodium
D0030154biological_processcell differentiation
D0030220biological_processplatelet formation
D0030291molecular_functionprotein serine/threonine kinase inhibitor activity
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0031122biological_processcytoplasmic microtubule organization
D0031267molecular_functionsmall GTPase binding
D0031982cellular_componentvesicle
D0032433cellular_componentfilopodium tip
D0032587cellular_componentruffle membrane
D0033630biological_processpositive regulation of cell adhesion mediated by integrin
D0038163biological_processthrombopoietin-mediated signaling pathway
D0042127biological_processregulation of cell population proliferation
D0042383cellular_componentsarcolemma
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043066biological_processnegative regulation of apoptotic process
D0043085biological_processpositive regulation of catalytic activity
D0043204cellular_componentperikaryon
D0043495molecular_functionmembrane-membrane adaptor activity
D0044325molecular_functiontransmembrane transporter binding
D0045653biological_processnegative regulation of megakaryocyte differentiation
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0051301biological_processcell division
D0051302biological_processregulation of cell division
D0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0070062cellular_componentextracellular exosome
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
D0071356biological_processcellular response to tumor necrosis factor
D0071363biological_processcellular response to growth factor stimulus
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0071944cellular_componentcell periphery
D0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
D0090314biological_processpositive regulation of protein targeting to membrane
D0097191biological_processextrinsic apoptotic signaling pathway
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D1903078biological_processpositive regulation of protein localization to plasma membrane
D1990090biological_processcellular response to nerve growth factor stimulus
D2000256biological_processpositive regulation of male germ cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue CA A 201
ChainResidue
AASP116
AASP118
AASP120
ATHR122
AASP127
AHOH334

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 202
ChainResidue
ATHR167
AGLU172
AHOH301
AASP161
AASP163
AASP165

site_idAC3
Number of Residues6
Detailsbinding site for residue CA B 201
ChainResidue
BASP116
BASP118
BASP120
BTHR122
BASP127
BHOH325

site_idAC4
Number of Residues5
Detailsbinding site for residue CA B 202
ChainResidue
BASP161
BASP163
BASP165
BTHR167
BGLU172

site_idAC5
Number of Residues5
Detailsbinding site for residue CA C 201
ChainResidue
CASP116
CASP118
CASP120
CTHR122
CASP127

site_idAC6
Number of Residues5
Detailsbinding site for residue CA C 202
ChainResidue
CASP161
CASP163
CASP165
CTHR167
CGLU172

site_idAC7
Number of Residues5
Detailsbinding site for residue CA D 201
ChainResidue
DASP116
DASP118
DASP120
DTHR122
DASP127

site_idAC8
Number of Residues5
Detailsbinding site for residue CA D 202
ChainResidue
DASP161
DASP163
DASP165
DTHR167
DGLU172

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DFDDDGTLNreDL
ChainResidueDetails
AASP116-LEU128
AASP161-PHE173

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23503467","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

PDB statisticsPDBj update infoContact PDBjnumon