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6OCX

Structure of human CIB1 in complex with peptide inhibitor UNC10245109

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001525biological_processangiogenesis
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002931biological_processresponse to ischemia
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006302biological_processdouble-strand break repair
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007026biological_processnegative regulation of microtubule depolymerization
A0007113biological_processendomitotic cell cycle
A0007155biological_processcell adhesion
A0007283biological_processspermatogenesis
A0007286biological_processspermatid development
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
A0010977biological_processnegative regulation of neuron projection development
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0030027cellular_componentlamellipodium
A0030154biological_processcell differentiation
A0030220biological_processplatelet formation
A0030291molecular_functionprotein serine/threonine kinase inhibitor activity
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0031122biological_processcytoplasmic microtubule organization
A0031267molecular_functionsmall GTPase binding
A0031982cellular_componentvesicle
A0032433cellular_componentfilopodium tip
A0032587cellular_componentruffle membrane
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0038163biological_processthrombopoietin-mediated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043085biological_processpositive regulation of catalytic activity
A0043204cellular_componentperikaryon
A0043495molecular_functionprotein-membrane adaptor activity
A0044325molecular_functiontransmembrane transporter binding
A0045653biological_processnegative regulation of megakaryocyte differentiation
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051301biological_processcell division
A0051302biological_processregulation of cell division
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0090314biological_processpositive regulation of protein targeting to membrane
A0097191biological_processextrinsic apoptotic signaling pathway
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1990090biological_processcellular response to nerve growth factor stimulus
A2000256biological_processpositive regulation of male germ cell proliferation
B0000287molecular_functionmagnesium ion binding
B0001525biological_processangiogenesis
B0001933biological_processnegative regulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0001954biological_processpositive regulation of cell-matrix adhesion
B0002931biological_processresponse to ischemia
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006302biological_processdouble-strand break repair
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007026biological_processnegative regulation of microtubule depolymerization
B0007113biological_processendomitotic cell cycle
B0007155biological_processcell adhesion
B0007283biological_processspermatogenesis
B0007286biological_processspermatid development
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
B0010977biological_processnegative regulation of neuron projection development
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0030027cellular_componentlamellipodium
B0030154biological_processcell differentiation
B0030220biological_processplatelet formation
B0030291molecular_functionprotein serine/threonine kinase inhibitor activity
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0031122biological_processcytoplasmic microtubule organization
B0031267molecular_functionsmall GTPase binding
B0031982cellular_componentvesicle
B0032433cellular_componentfilopodium tip
B0032587cellular_componentruffle membrane
B0033630biological_processpositive regulation of cell adhesion mediated by integrin
B0038163biological_processthrombopoietin-mediated signaling pathway
B0042127biological_processregulation of cell population proliferation
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043066biological_processnegative regulation of apoptotic process
B0043085biological_processpositive regulation of catalytic activity
B0043204cellular_componentperikaryon
B0043495molecular_functionprotein-membrane adaptor activity
B0044325molecular_functiontransmembrane transporter binding
B0045653biological_processnegative regulation of megakaryocyte differentiation
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051301biological_processcell division
B0051302biological_processregulation of cell division
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0070062cellular_componentextracellular exosome
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
B0071356biological_processcellular response to tumor necrosis factor
B0071363biological_processcellular response to growth factor stimulus
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0071944cellular_componentcell periphery
B0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
B0090314biological_processpositive regulation of protein targeting to membrane
B0097191biological_processextrinsic apoptotic signaling pathway
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1990090biological_processcellular response to nerve growth factor stimulus
B2000256biological_processpositive regulation of male germ cell proliferation
C0000287molecular_functionmagnesium ion binding
C0001525biological_processangiogenesis
C0001933biological_processnegative regulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0001954biological_processpositive regulation of cell-matrix adhesion
C0002931biological_processresponse to ischemia
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006302biological_processdouble-strand break repair
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007026biological_processnegative regulation of microtubule depolymerization
C0007113biological_processendomitotic cell cycle
C0007155biological_processcell adhesion
C0007283biological_processspermatogenesis
C0007286biological_processspermatid development
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
C0010977biological_processnegative regulation of neuron projection development
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0030027cellular_componentlamellipodium
C0030154biological_processcell differentiation
C0030220biological_processplatelet formation
C0030291molecular_functionprotein serine/threonine kinase inhibitor activity
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0031122biological_processcytoplasmic microtubule organization
C0031267molecular_functionsmall GTPase binding
C0031982cellular_componentvesicle
C0032433cellular_componentfilopodium tip
C0032587cellular_componentruffle membrane
C0033630biological_processpositive regulation of cell adhesion mediated by integrin
C0038163biological_processthrombopoietin-mediated signaling pathway
C0042127biological_processregulation of cell population proliferation
C0042383cellular_componentsarcolemma
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043066biological_processnegative regulation of apoptotic process
C0043085biological_processpositive regulation of catalytic activity
C0043204cellular_componentperikaryon
C0043495molecular_functionprotein-membrane adaptor activity
C0044325molecular_functiontransmembrane transporter binding
C0045653biological_processnegative regulation of megakaryocyte differentiation
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0051301biological_processcell division
C0051302biological_processregulation of cell division
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
C0071356biological_processcellular response to tumor necrosis factor
C0071363biological_processcellular response to growth factor stimulus
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0071944cellular_componentcell periphery
C0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
C0090314biological_processpositive regulation of protein targeting to membrane
C0097191biological_processextrinsic apoptotic signaling pathway
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1903078biological_processpositive regulation of protein localization to plasma membrane
C1990090biological_processcellular response to nerve growth factor stimulus
C2000256biological_processpositive regulation of male germ cell proliferation
D0000287molecular_functionmagnesium ion binding
D0001525biological_processangiogenesis
D0001933biological_processnegative regulation of protein phosphorylation
D0001934biological_processpositive regulation of protein phosphorylation
D0001954biological_processpositive regulation of cell-matrix adhesion
D0002931biological_processresponse to ischemia
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005813cellular_componentcentrosome
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006302biological_processdouble-strand break repair
D0006915biological_processapoptotic process
D0006974biological_processDNA damage response
D0007026biological_processnegative regulation of microtubule depolymerization
D0007113biological_processendomitotic cell cycle
D0007155biological_processcell adhesion
D0007283biological_processspermatogenesis
D0007286biological_processspermatid development
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
D0010977biological_processnegative regulation of neuron projection development
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0030027cellular_componentlamellipodium
D0030154biological_processcell differentiation
D0030220biological_processplatelet formation
D0030291molecular_functionprotein serine/threonine kinase inhibitor activity
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0031122biological_processcytoplasmic microtubule organization
D0031267molecular_functionsmall GTPase binding
D0031982cellular_componentvesicle
D0032433cellular_componentfilopodium tip
D0032587cellular_componentruffle membrane
D0033630biological_processpositive regulation of cell adhesion mediated by integrin
D0038163biological_processthrombopoietin-mediated signaling pathway
D0042127biological_processregulation of cell population proliferation
D0042383cellular_componentsarcolemma
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043066biological_processnegative regulation of apoptotic process
D0043085biological_processpositive regulation of catalytic activity
D0043204cellular_componentperikaryon
D0043495molecular_functionprotein-membrane adaptor activity
D0044325molecular_functiontransmembrane transporter binding
D0045653biological_processnegative regulation of megakaryocyte differentiation
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0051301biological_processcell division
D0051302biological_processregulation of cell division
D0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0070062cellular_componentextracellular exosome
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
D0071356biological_processcellular response to tumor necrosis factor
D0071363biological_processcellular response to growth factor stimulus
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0071944cellular_componentcell periphery
D0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
D0090314biological_processpositive regulation of protein targeting to membrane
D0097191biological_processextrinsic apoptotic signaling pathway
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D1903078biological_processpositive regulation of protein localization to plasma membrane
D1990090biological_processcellular response to nerve growth factor stimulus
D2000256biological_processpositive regulation of male germ cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue CA A 201
ChainResidue
AASP116
AASP118
AASP120
ATHR122
AASP127
AHOH334

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 202
ChainResidue
ATHR167
AGLU172
AHOH301
AASP161
AASP163
AASP165

site_idAC3
Number of Residues6
Detailsbinding site for residue CA B 201
ChainResidue
BASP116
BASP118
BASP120
BTHR122
BASP127
BHOH325

site_idAC4
Number of Residues5
Detailsbinding site for residue CA B 202
ChainResidue
BASP161
BASP163
BASP165
BTHR167
BGLU172

site_idAC5
Number of Residues5
Detailsbinding site for residue CA C 201
ChainResidue
CASP116
CASP118
CASP120
CTHR122
CASP127

site_idAC6
Number of Residues5
Detailsbinding site for residue CA C 202
ChainResidue
CASP161
CASP163
CASP165
CTHR167
CGLU172

site_idAC7
Number of Residues5
Detailsbinding site for residue CA D 201
ChainResidue
DASP116
DASP118
DASP120
DTHR122
DASP127

site_idAC8
Number of Residues5
Detailsbinding site for residue CA D 202
ChainResidue
DASP161
DASP163
DASP165
DTHR167
DGLU172

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DFDDDGTLNreDL
ChainResidueDetails
AASP116-LEU128
AASP161-PHE173

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AASP116
AGLU172
BASP116
BASP118
BASP120
BTHR122
BASP127
BASP161
BASP163
BASP165
BTHR167
AASP118
BGLU172
CASP116
CASP118
CASP120
CTHR122
CASP127
CASP161
CASP163
CASP165
CTHR167
AASP120
CGLU172
DASP116
DASP118
DASP120
DTHR122
DASP127
DASP161
DASP163
DASP165
DTHR167
ATHR122
DGLU172
AASP127
AASP161
AASP163
AASP165
ATHR167

site_idSWS_FT_FI2
Number of Residues4
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:10366599
ChainResidueDetails
AGLY2
BGLY2
CGLY2
DGLY2

226707

PDB entries from 2024-10-30

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