6OCQ

Crystal structure of RIP1 kinase in complex with a pyrrolidine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue M5J A 301

Chain	Residue
A	MET67
A	SER161
A	VAL76
A	MET92
A	LEU129
A	VAL134
A	HIS136
A	ILE154
A	ALA155
A	ASP156

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	ILE252
A	GLU254
A	TYR255
A	CYS256

---

site_id	AC3
Number of Residues	8
Details	binding site for residue M5J B 301

Chain	Residue
B	MET67
B	LEU70
B	VAL76
B	LEU78
B	ILE154
B	ALA155
B	ASP156
B	PHE162

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 302

Chain	Residue
B	VAL249
B	ILE252
B	GLU254
B	CYS256

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHkDLKpeNILV

Chain	Residue	Details
A	VAL134-VAL146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP138
B	ASP138

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU23
A	LYS45
B	LEU23
B	LYS45

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by IKKA and IKKB => ECO:0000269|PubMed:18408713

Chain	Residue	Details
A	SER6
B	SER6

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000255

Chain	Residue	Details
A	SER20
B	SER20

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by IKKA and IKKB => ECO:0000269|PubMed:18408713, ECO:0000269|PubMed:30988283

Chain	Residue	Details
A	SER25
B	SER25

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by RIPK3 and autocatalysis => ECO:0000255

Chain	Residue	Details
A	SER161
B	SER161

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000255, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:31827280

Chain	Residue	Details
A	SER166
B	SER166

---