Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6OC9

S8 phosphorylated beta amyloid 40 fibrils

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
B	0016020	cellular_component	membrane
C	0016020	cellular_component	membrane
D	0016020	cellular_component	membrane
E	0016020	cellular_component	membrane
F	0016020	cellular_component	membrane
G	0016020	cellular_component	membrane
H	0016020	cellular_component	membrane
I	0016020	cellular_component	membrane
J	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue 2PO A 101

Chain	Residue
A	ARG5
A	ASP7
A	SER8
B	GLU3
B	GLY25

site_id	AC2
Number of Residues	8
Details	binding site for residue 2PO B 101

Chain	Residue
B	GLY9
C	HIS6
C	ASP7
C	SER8
A	SER8
A	GLY9
B	GLU3
B	SER8

site_id	AC3
Number of Residues	6
Details	binding site for residue 2PO C 101

Chain	Residue
C	GLU3
C	SER8
C	TYR10
C	VAL24
D	HIS6
D	ASP7

site_id	AC4
Number of Residues	8
Details	binding site for residue 2PO D 101

Chain	Residue
C	TYR10
C	VAL24
D	SER8
D	GLY9
D	GLU22
D	ASP23
D	VAL24
E	ASP23

site_id	AC5
Number of Residues	6
Details	binding site for residue 2PO E 101

Chain	Residue
C	SER8
D	ASP7
D	SER8
D	GLY9
E	GLU3
E	SER8

site_id	AC6
Number of Residues	4
Details	binding site for residue 2PO F 101

Chain	Residue
F	GLU3
F	SER8
G	SER8
G	2PO101

site_id	AC7
Number of Residues	4
Details	binding site for residue 2PO G 101

Chain	Residue
F	2PO101
G	GLU3
G	PHE4
G	SER8

site_id	AC8
Number of Residues	5
Details	binding site for residue 2PO H 101

Chain	Residue
G	GLU3
H	GLU3
H	HIS6
H	ASP7
H	SER8

site_id	AC9
Number of Residues	3
Details	binding site for residue 2PO I 101

Chain	Residue
I	GLU3
I	SER8
J	SER8

site_id	AD1
Number of Residues	5
Details	binding site for residue 2PO J 101

Chain	Residue
J	ALA2
J	GLU3
J	HIS6
J	ASP7
J	SER8

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:11274207, ECO:0000269\|PubMed:26898943

Chain	Residue	Details
A	GLY25
E	GLY33
F	GLY25
F	GLY33
G	GLY25
G	GLY33
H	GLY25
H	GLY33
I	GLY25
I	GLY33
J	GLY25
A	GLY33
J	GLY33
B	GLY25
B	GLY33
C	GLY25
C	GLY33
D	GLY25
D	GLY33
E	GLY25

site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000305\|PubMed:10413512, ECO:0000305\|PubMed:11274207

Chain	Residue	Details
A	GLY29
J	GLY29
B	GLY29
C	GLY29
D	GLY29
E	GLY29
F	GLY29
G	GLY29
H	GLY29
I	GLY29

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:10413512, ECO:0000269\|PubMed:11274207, ECO:0000269\|PubMed:26898943

Chain	Residue	Details
A	ILE32
J	ILE32
B	ILE32
C	ILE32
D	ILE32
E	ILE32
F	ILE32
G	ILE32
H	ILE32
I	ILE32

site_id	SWS_FT_FI4
Number of Residues	10
Details	SITE: Cleavage; by beta-secretase => ECO:0000305\|PubMed:11851430

Chain	Residue	Details
A	PHE19
J	PHE19
B	PHE19
C	PHE19
D	PHE19
E	PHE19
F	PHE19
G	PHE19
H	PHE19
I	PHE19

site_id	SWS_FT_FI5
Number of Residues	10
Details	SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671

Chain	Residue	Details
A	PHE20
J	PHE20
B	PHE20
C	PHE20
D	PHE20
E	PHE20
F	PHE20
G	PHE20
H	PHE20
I	PHE20

site_id	SWS_FT_FI6
Number of Residues	10
Details	SITE: Cleavage; by ACE => ECO:0000269\|PubMed:11604391, ECO:0000269\|PubMed:16154999

Chain	Residue	Details
A	SER26
J	SER26
B	SER26
C	SER26
D	SER26
E	SER26
F	SER26
G	SER26
H	SER26
I	SER26

site_id	SWS_FT_FI7
Number of Residues	10
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305\|PubMed:11851430

Chain	Residue	Details
A	MET35
J	MET35
B	MET35
C	MET35
D	MET35
E	MET35
F	MET35
G	MET35
H	MET35
I	MET35

site_id	SWS_FT_FI8
Number of Residues	10
Details	SITE: Cleavage; by theta-secretase => ECO:0000269\|PubMed:16816112

Chain	Residue	Details
A	GLY38
J	GLY38
B	GLY38
C	GLY38
D	GLY38
E	GLY38
F	GLY38
G	GLY38
H	GLY38
I	GLY38

site_id	SWS_FT_FI9
Number of Residues	10
Details	CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms => ECO:0000269\|PubMed:21712440

Chain	Residue	Details
A	PHE4
J	PHE4
B	PHE4
C	PHE4
D	PHE4
E	PHE4
F	PHE4
G	PHE4
H	PHE4
I	PHE4

site_id	SWS_FT_FI10
Number of Residues	10
Details	CARBOHYD: O-linked (HexNAc...) threonine; partial => ECO:0000269\|PubMed:22576872

Chain	Residue	Details
A	ASP7
J	ASP7
B	ASP7
C	ASP7
D	ASP7
E	ASP7
F	ASP7
G	ASP7
H	ASP7
I	ASP7

site_id	SWS_FT_FI11
Number of Residues	10
Details	CARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269\|PubMed:22576872, ECO:0000305\|PubMed:21712440

Chain	Residue	Details
A	GLU11
J	GLU11
B	GLU11
C	GLU11
D	GLU11
E	GLU11
F	GLU11
G	GLU11
H	GLU11
I	GLU11

site_id	SWS_FT_FI12
Number of Residues	10
Details	CARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269\|PubMed:22576872, ECO:0000305\|PubMed:21712440

Chain	Residue	Details
A	GLN15
J	GLN15
B	GLN15
C	GLN15
D	GLN15
E	GLN15
F	GLN15
G	GLN15
H	GLN15
I	GLN15

site_id	SWS_FT_FI13
Number of Residues	10
Details	CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269\|PubMed:22576872

Chain	Residue	Details
A	GLY29
J	GLY29
B	GLY29
C	GLY29
D	GLY29
E	GLY29
F	GLY29
G	GLY29
H	GLY29
I	GLY29

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)