6OC9
S8 phosphorylated beta amyloid 40 fibrils
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| B | 0016020 | cellular_component | membrane |
| C | 0016020 | cellular_component | membrane |
| D | 0016020 | cellular_component | membrane |
| E | 0016020 | cellular_component | membrane |
| F | 0016020 | cellular_component | membrane |
| G | 0016020 | cellular_component | membrane |
| H | 0016020 | cellular_component | membrane |
| I | 0016020 | cellular_component | membrane |
| J | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue 2PO A 101 |
| Chain | Residue |
| A | ARG5 |
| A | ASP7 |
| A | SER8 |
| B | GLU3 |
| B | GLY25 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 2PO B 101 |
| Chain | Residue |
| B | GLY9 |
| C | HIS6 |
| C | ASP7 |
| C | SER8 |
| A | SER8 |
| A | GLY9 |
| B | GLU3 |
| B | SER8 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue 2PO C 101 |
| Chain | Residue |
| C | GLU3 |
| C | SER8 |
| C | TYR10 |
| C | VAL24 |
| D | HIS6 |
| D | ASP7 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 2PO D 101 |
| Chain | Residue |
| C | TYR10 |
| C | VAL24 |
| D | SER8 |
| D | GLY9 |
| D | GLU22 |
| D | ASP23 |
| D | VAL24 |
| E | ASP23 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue 2PO E 101 |
| Chain | Residue |
| C | SER8 |
| D | ASP7 |
| D | SER8 |
| D | GLY9 |
| E | GLU3 |
| E | SER8 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue 2PO F 101 |
| Chain | Residue |
| F | GLU3 |
| F | SER8 |
| G | SER8 |
| G | 2PO101 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue 2PO G 101 |
| Chain | Residue |
| F | 2PO101 |
| G | GLU3 |
| G | PHE4 |
| G | SER8 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue 2PO H 101 |
| Chain | Residue |
| G | GLU3 |
| H | GLU3 |
| H | HIS6 |
| H | ASP7 |
| H | SER8 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue 2PO I 101 |
| Chain | Residue |
| I | GLU3 |
| I | SER8 |
| J | SER8 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue 2PO J 101 |
| Chain | Residue |
| J | ALA2 |
| J | GLU3 |
| J | HIS6 |
| J | ASP7 |
| J | SER8 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 230 |
| Details | Peptide: {"description":"P3(40)","featureId":"PRO_0000000096"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Site: {"description":"Cleavage; by caspase-6; when associated with variant 670-N-L-671"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | Site: {"description":"Cleavage; by ACE","evidences":[{"source":"PubMed","id":"11604391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16154999","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Site: {"description":"Cleavage; by alpha-secretase","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | Site: {"description":"Cleavage; by theta-secretase","evidences":[{"source":"PubMed","id":"16816112","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Site: {"description":"Implicated in free radical propagation","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Site: {"description":"Susceptible to oxidation","evidences":[{"source":"PubMed","id":"10535332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"O-linked (HexNAc...) tyrosine; partial","evidences":[{"source":"PubMed","id":"22576872","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
