6OB7
Human equilibrative nucleoside transporter-1, dilazep bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001504 | biological_process | neurotransmitter uptake |
| A | 0005326 | molecular_function | neurotransmitter transmembrane transporter activity |
| A | 0005337 | molecular_function | nucleoside transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0007595 | biological_process | lactation |
| A | 0015207 | molecular_function | adenine transmembrane transporter activity |
| A | 0015208 | molecular_function | guanine transmembrane transporter activity |
| A | 0015210 | molecular_function | uracil transmembrane transporter activity |
| A | 0015211 | molecular_function | purine nucleoside transmembrane transporter activity |
| A | 0015212 | molecular_function | cytidine transmembrane transporter activity |
| A | 0015213 | molecular_function | uridine transmembrane transporter activity |
| A | 0015389 | molecular_function | pyrimidine- and adenosine-specific:sodium symporter activity |
| A | 0015851 | biological_process | nucleobase transport |
| A | 0015853 | biological_process | adenine transport |
| A | 0015858 | biological_process | nucleoside transport |
| A | 0015860 | biological_process | purine nucleoside transmembrane transport |
| A | 0015861 | biological_process | cytidine transport |
| A | 0015862 | biological_process | uridine transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0032238 | biological_process | adenosine transport |
| A | 0035340 | biological_process | inosine transport |
| A | 0035344 | biological_process | hypoxanthine transport |
| A | 0035364 | biological_process | thymine transport |
| A | 0060079 | biological_process | excitatory postsynaptic potential |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 0072531 | biological_process | pyrimidine-containing compound transmembrane transport |
| A | 0098793 | cellular_component | presynapse |
| A | 0098794 | cellular_component | postsynapse |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1901642 | biological_process | nucleoside transmembrane transport |
| A | 1903716 | biological_process | guanine transmembrane transport |
| A | 1903791 | biological_process | uracil transmembrane transport |
| A | 1904082 | biological_process | pyrimidine nucleobase transmembrane transport |
| A | 1904823 | biological_process | purine nucleobase transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 601 |
| Chain | Residue |
| A | SER290 |
| A | PHE294 |
| A | SER295 |
| A | TYR385 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 602 |
| Chain | Residue |
| A | TYR11 |
| A | LEU16 |
| A | VAL141 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue OLC A 603 |
| Chain | Residue |
| A | LEU134 |
| A | ILE142 |
| A | SER171 |
| A | LEU343 |
| A | SER346 |
| A | VAL350 |
| A | TRP15 |
| A | ILE125 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue OLC A 604 |
| Chain | Residue |
| A | ARG105 |
| A | ILE106 |
| A | PRO107 |
| A | VAL110 |
| A | TYR327 |
| A | OLC608 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 605 |
| Chain | Residue |
| A | HIS392 |
| A | OLC606 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 606 |
| Chain | Residue |
| A | TRP395 |
| A | PHE398 |
| A | OLC605 |
| A | OLC613 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 607 |
| Chain | Residue |
| A | THR85 |
| A | VAL447 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue OLC A 608 |
| Chain | Residue |
| A | TRP324 |
| A | PHE328 |
| A | VAL331 |
| A | ILE397 |
| A | OLC604 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 609 |
| Chain | Residue |
| A | SER109 |
| A | LEU113 |
| A | TRP324 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 610 |
| Chain | Residue |
| A | VAL331 |
| A | THR336 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 611 |
| Chain | Residue |
| A | PHE351 |
| A | TRP353 |
| A | TYR409 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 612 |
| Chain | Residue |
| A | ILE128 |
| A | PHE351 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 613 |
| Chain | Residue |
| A | TRP395 |
| A | OLC606 |
| A | OLC614 |
| A | HOH711 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 614 |
| Chain | Residue |
| A | VAL388 |
| A | OLC613 |
| A | HOH718 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 615 |
| Chain | Residue |
| A | LYS131 |
| A | SER202 |
| A | GLU203 |
| A | PHE206 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue OLC A 616 |
| Chain | Residue |
| A | MET144 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue OLC A 617 |
| Chain | Residue |
| A | PHE186 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 618 |
| Chain | Residue |
| A | GLU203 |
| A | PHE206 |
| A | THR211 |
| site_id | AE1 |
| Number of Residues | 16 |
| Details | binding site for residue 8DZ A 619 |
| Chain | Residue |
| A | LEU26 |
| A | TRP29 |
| A | ASN30 |
| A | MET33 |
| A | THR34 |
| A | THR85 |
| A | GLN158 |
| A | SER188 |
| A | PHE307 |
| A | PHE334 |
| A | ASN338 |
| A | LEU438 |
| A | HOH725 |
| A | HOH749 |
| A | HOH751 |
| A | HOH752 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:11584005 |
| Chain | Residue | Details |
| A | THR2-LYS12 | |
| A | GLN108-ARG111 | |
| A | ARG228-THR323 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 214 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA13-TRP29 | |
| A | GLU426-GLY445 | |
| A | VAL83-PRO107 | |
| A | ILE112-VAL130 | |
| A | PHE139-LEU157 | |
| A | ALA175-SER199 | |
| A | GLY207-PRO227 | |
| A | TRP324-LEU343 | |
| A | LYS356-LEU374 | |
| A | HIS392-LEU410 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 93 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:11584005 |
| Chain | Residue | Details |
| A | ASN30-ASN82 | |
| A | LYS131-PRO138 | |
| A | GLU200-PHE206 | |
| A | GLY344-GLY355 | |
| A | ALA411-ALA425 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 49 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN158-ALA174 | |
| A | LEU375-GLU391 | |
| A | ALA446-VAL463 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Not glycosylated => ECO:0000269|PubMed:11584005 |
| Chain | Residue | Details |
| A | ALA309 | |
| A | GLY320 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Essential for nucleobase transport => ECO:0000269|PubMed:21795683 |
| Chain | Residue | Details |
| A | ALA446 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | LEU286 | |
| A | THR301 | |
| A | GLY305 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11584005, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN48 |
