6OAD
2.05 Angstrom Resolution Crystal Structure of Aminopeptidase B from Escherichia coli str. K-12 substr. MG1655.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043171 | biological_process | peptide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043171 | biological_process | peptide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043171 | biological_process | peptide catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019538 | biological_process | protein metabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043171 | biological_process | peptide catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0019538 | biological_process | protein metabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043171 | biological_process | peptide catabolic process |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0019538 | biological_process | protein metabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043171 | biological_process | peptide catabolic process |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
| G | 0004177 | molecular_function | aminopeptidase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006508 | biological_process | proteolysis |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0019538 | biological_process | protein metabolic process |
| G | 0030145 | molecular_function | manganese ion binding |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0043171 | biological_process | peptide catabolic process |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070006 | molecular_function | metalloaminopeptidase activity |
| H | 0004177 | molecular_function | aminopeptidase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006508 | biological_process | proteolysis |
| H | 0008233 | molecular_function | peptidase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0019538 | biological_process | protein metabolic process |
| H | 0030145 | molecular_function | manganese ion binding |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0043171 | biological_process | peptide catabolic process |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070006 | molecular_function | metalloaminopeptidase activity |
| I | 0004177 | molecular_function | aminopeptidase activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0006508 | biological_process | proteolysis |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0019538 | biological_process | protein metabolic process |
| I | 0030145 | molecular_function | manganese ion binding |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0043171 | biological_process | peptide catabolic process |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0070006 | molecular_function | metalloaminopeptidase activity |
| J | 0004177 | molecular_function | aminopeptidase activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006508 | biological_process | proteolysis |
| J | 0008233 | molecular_function | peptidase activity |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0019538 | biological_process | protein metabolic process |
| J | 0030145 | molecular_function | manganese ion binding |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0043171 | biological_process | peptide catabolic process |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0070006 | molecular_function | metalloaminopeptidase activity |
| K | 0004177 | molecular_function | aminopeptidase activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0005829 | cellular_component | cytosol |
| K | 0006508 | biological_process | proteolysis |
| K | 0008233 | molecular_function | peptidase activity |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0019538 | biological_process | protein metabolic process |
| K | 0030145 | molecular_function | manganese ion binding |
| K | 0042802 | molecular_function | identical protein binding |
| K | 0043171 | biological_process | peptide catabolic process |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0070006 | molecular_function | metalloaminopeptidase activity |
| L | 0004177 | molecular_function | aminopeptidase activity |
| L | 0005515 | molecular_function | protein binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0005829 | cellular_component | cytosol |
| L | 0006508 | biological_process | proteolysis |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0019538 | biological_process | protein metabolic process |
| L | 0030145 | molecular_function | manganese ion binding |
| L | 0042802 | molecular_function | identical protein binding |
| L | 0043171 | biological_process | peptide catabolic process |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | LYS195 |
| A | ASP200 |
| A | ASP218 |
| A | GLU279 |
| A | ZN502 |
| A | BCT505 |
| A | HOH790 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | GLU279 |
| A | ZN501 |
| A | HOH790 |
| A | ASP200 |
| A | ASP277 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 503 |
| Chain | Residue |
| A | THR113 |
| A | ILE114 |
| A | ALA116 |
| A | LYS216 |
| A | MET219 |
| A | HOH679 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | ARG352 |
| A | HIS383 |
| A | HOH614 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue BCT A 505 |
| Chain | Residue |
| A | LYS195 |
| A | ASP277 |
| A | ALA278 |
| A | GLU279 |
| A | GLY280 |
| A | ARG281 |
| A | LEU305 |
| A | ZN501 |
| A | HOH790 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | TRP72 |
| A | GLN76 |
| A | ASN339 |
| A | ARG419 |
| A | HOH683 |
| A | HOH770 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | GLU154 |
| K | SER124 |
| K | GLN125 |
| K | LYS148 |
| K | ARG169 |
| K | HOH636 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | TRP75 |
| A | ARG85 |
| A | LYS86 |
| A | VAL87 |
| A | TRP89 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue PGE A 509 |
| Chain | Residue |
| A | GLY307 |
| A | ALA308 |
| A | THR365 |
| A | HOH661 |
| A | HOH700 |
| A | HOH781 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | LYS195 |
| B | ASP200 |
| B | ASP218 |
| B | GLU279 |
| B | ZN502 |
| B | HOH741 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | ASP200 |
| B | ASP277 |
| B | GLU279 |
| B | ZN501 |
| B | HOH741 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 503 |
| Chain | Residue |
| B | THR113 |
| B | ILE114 |
| B | ALA116 |
| B | LYS216 |
| B | MET219 |
| B | HOH752 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | LYS269 |
| B | ARG352 |
| B | HIS383 |
| B | HOH661 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue BCT B 505 |
| Chain | Residue |
| B | LYS195 |
| B | ALA278 |
| B | GLU279 |
| B | GLY280 |
| B | ARG281 |
| B | LEU305 |
| B | HOH741 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | TRP72 |
| B | GLN76 |
| B | ASN339 |
| B | ARG419 |
| B | HOH618 |
| B | HOH784 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | LYS148 |
| B | GLU168 |
| B | ARG169 |
| B | SER170 |
| B | HOH686 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 508 |
| Chain | Residue |
| B | VAL87 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue ZN C 501 |
| Chain | Residue |
| C | HOH725 |
| C | LYS195 |
| C | ASP200 |
| C | ASP218 |
| C | GLU279 |
| C | ZN502 |
| C | BCT505 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 502 |
| Chain | Residue |
| C | ASP200 |
| C | ASP277 |
| C | GLU279 |
| C | ZN501 |
| C | HOH725 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 503 |
| Chain | Residue |
| C | THR113 |
| C | ILE114 |
| C | ALA116 |
| C | LYS216 |
| C | MET219 |
| C | HOH683 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 504 |
| Chain | Residue |
| C | LYS148 |
| C | SER170 |
| C | HOH846 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue BCT C 505 |
| Chain | Residue |
| C | LYS195 |
| C | ALA278 |
| C | GLU279 |
| C | GLY280 |
| C | ARG281 |
| C | LEU305 |
| C | ZN501 |
| C | HOH725 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue BCT C 506 |
| Chain | Residue |
| C | ASP151 |
| C | GLU154 |
| C | HOH607 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 507 |
| Chain | Residue |
| C | TRP72 |
| C | GLN76 |
| C | ASN339 |
| C | ARG419 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 508 |
| Chain | Residue |
| C | PRO296 |
| C | ILE299 |
| C | ASN387 |
| C | GLN390 |
| C | HOH619 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 509 |
| Chain | Residue |
| C | GLU386 |
| C | ASN387 |
| C | TYR388 |
| C | GLN389 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 510 |
| Chain | Residue |
| C | ARG85 |
| C | LYS86 |
| C | VAL87 |
| C | HOH606 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 501 |
| Chain | Residue |
| D | LYS195 |
| D | ASP200 |
| D | ASP218 |
| D | GLU279 |
| D | ZN502 |
| D | HOH747 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 502 |
| Chain | Residue |
| D | ASP200 |
| D | ASP277 |
| D | GLU279 |
| D | ZN501 |
| D | EDO508 |
| D | HOH747 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue CA D 503 |
| Chain | Residue |
| D | THR113 |
| D | ILE114 |
| D | ALA116 |
| D | LEU121 |
| D | LYS216 |
| D | MET219 |
| D | HOH740 |
| site_id | AF4 |
| Number of Residues | 8 |
| Details | binding site for residue BCT D 504 |
| Chain | Residue |
| D | LYS195 |
| D | ALA278 |
| D | GLU279 |
| D | GLY280 |
| D | ARG281 |
| D | LEU305 |
| D | PEG511 |
| D | HOH747 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue BCT D 505 |
| Chain | Residue |
| D | ARG352 |
| D | SER353 |
| D | LEU355 |
| D | GLU361 |
| D | HOH715 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue BCT D 506 |
| Chain | Residue |
| D | LYS148 |
| D | GLU168 |
| D | ARG169 |
| D | SER170 |
| D | HOH608 |
| D | HOH672 |
| D | HOH725 |
| D | HOH733 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 507 |
| Chain | Residue |
| D | TRP72 |
| D | GLN76 |
| D | ASN339 |
| D | ARG419 |
| D | HOH616 |
| D | HOH765 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 508 |
| Chain | Residue |
| D | LYS207 |
| D | THR304 |
| D | LEU305 |
| D | ZN502 |
| D | HOH720 |
| D | HOH747 |
| D | HOH788 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 509 |
| Chain | Residue |
| D | TRP75 |
| D | LYS86 |
| D | VAL87 |
| D | TRP89 |
| D | HOH798 |
| site_id | AG1 |
| Number of Residues | 8 |
| Details | binding site for residue PEG D 510 |
| Chain | Residue |
| D | SER292 |
| D | PRO296 |
| D | ILE299 |
| D | VAL385 |
| D | GLU386 |
| D | ASN387 |
| D | GLN390 |
| D | GLY391 |
| site_id | AG2 |
| Number of Residues | 7 |
| Details | binding site for residue PEG D 511 |
| Chain | Residue |
| D | ASP277 |
| D | THR306 |
| D | GLY307 |
| D | ALA308 |
| D | BCT504 |
| D | HOH677 |
| D | HOH782 |
| site_id | AG3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN E 501 |
| Chain | Residue |
| E | LYS195 |
| E | ASP200 |
| E | ASP218 |
| E | GLU279 |
| E | ZN502 |
| E | BCT505 |
| E | HOH745 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN E 502 |
| Chain | Residue |
| E | ASP200 |
| E | ASP277 |
| E | GLU279 |
| E | ZN501 |
| E | HOH745 |
| site_id | AG5 |
| Number of Residues | 7 |
| Details | binding site for residue CA E 503 |
| Chain | Residue |
| E | THR113 |
| E | ILE114 |
| E | ALA116 |
| E | LEU121 |
| E | LYS216 |
| E | MET219 |
| E | HOH703 |
| site_id | AG6 |
| Number of Residues | 2 |
| Details | binding site for residue CL E 504 |
| Chain | Residue |
| A | GLU64 |
| E | ASP69 |
| site_id | AG7 |
| Number of Residues | 9 |
| Details | binding site for residue BCT E 505 |
| Chain | Residue |
| E | LYS195 |
| E | ASP277 |
| E | ALA278 |
| E | GLU279 |
| E | GLY280 |
| E | ARG281 |
| E | LEU305 |
| E | ZN501 |
| E | HOH745 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 506 |
| Chain | Residue |
| E | LYS148 |
| E | SER170 |
| E | HOH682 |
| E | HOH684 |
| site_id | AG9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 507 |
| Chain | Residue |
| E | TRP72 |
| E | GLN76 |
| E | ASN339 |
| E | ARG419 |
| E | HOH608 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 508 |
| Chain | Residue |
| E | TRP75 |
| E | ARG85 |
| E | VAL87 |
| E | TRP89 |
| E | HOH729 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue PEG E 509 |
| Chain | Residue |
| E | ASP277 |
| E | THR306 |
| E | GLY307 |
| E | ALA308 |
| site_id | AH3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN F 501 |
| Chain | Residue |
| F | LYS195 |
| F | ASP200 |
| F | ASP218 |
| F | GLU279 |
| F | ZN502 |
| F | BCT505 |
| F | HOH609 |
| site_id | AH4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN F 502 |
| Chain | Residue |
| F | ASP200 |
| F | ASP277 |
| F | GLU279 |
| F | ZN501 |
| F | EDO507 |
| F | HOH609 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue CA F 503 |
| Chain | Residue |
| F | THR113 |
| F | ILE114 |
| F | ALA116 |
| F | LYS216 |
| F | MET219 |
| F | HOH686 |
| site_id | AH6 |
| Number of Residues | 3 |
| Details | binding site for residue CL F 504 |
| Chain | Residue |
| F | ARG169 |
| F | SER170 |
| F | HOH633 |
| site_id | AH7 |
| Number of Residues | 8 |
| Details | binding site for residue BCT F 505 |
| Chain | Residue |
| F | LYS195 |
| F | ALA278 |
| F | GLU279 |
| F | GLY280 |
| F | ARG281 |
| F | LEU305 |
| F | ZN501 |
| F | HOH609 |
| site_id | AH8 |
| Number of Residues | 4 |
| Details | binding site for residue BCT F 506 |
| Chain | Residue |
| F | THR306 |
| F | GLY307 |
| F | ALA308 |
| F | HOH678 |
| site_id | AH9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO F 507 |
| Chain | Residue |
| F | LYS207 |
| F | THR304 |
| F | LEU305 |
| F | ZN502 |
| F | HOH609 |
| F | HOH691 |
| F | HOH799 |
| site_id | AI1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO F 508 |
| Chain | Residue |
| F | TRP72 |
| F | GLN76 |
| F | ASN339 |
| F | ARG419 |
| F | HOH637 |
| F | HOH661 |
| F | HOH677 |
| site_id | AI2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 509 |
| Chain | Residue |
| F | LYS86 |
| F | VAL87 |
| F | TRP89 |
| site_id | AI3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN G 501 |
| Chain | Residue |
| G | LYS195 |
| G | ASP200 |
| G | ASP218 |
| G | GLU279 |
| G | ZN502 |
| G | BCT504 |
| G | HOH656 |
| site_id | AI4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN G 502 |
| Chain | Residue |
| G | ASP200 |
| G | ASP277 |
| G | GLU279 |
| G | ZN501 |
| G | HOH656 |
| G | HOH657 |
| site_id | AI5 |
| Number of Residues | 7 |
| Details | binding site for residue CA G 503 |
| Chain | Residue |
| G | THR113 |
| G | ILE114 |
| G | ALA116 |
| G | LEU121 |
| G | LYS216 |
| G | MET219 |
| G | HOH732 |
| site_id | AI6 |
| Number of Residues | 8 |
| Details | binding site for residue BCT G 504 |
| Chain | Residue |
| G | LYS195 |
| G | ALA278 |
| G | GLU279 |
| G | GLY280 |
| G | ARG281 |
| G | LEU305 |
| G | ZN501 |
| G | HOH656 |
| site_id | AI7 |
| Number of Residues | 6 |
| Details | binding site for residue BCT G 505 |
| Chain | Residue |
| G | PRO296 |
| G | ASN387 |
| G | GLN390 |
| G | GLY391 |
| G | HOH661 |
| G | HOH733 |
| site_id | AI8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO G 506 |
| Chain | Residue |
| G | TRP72 |
| G | GLN76 |
| G | ASN339 |
| G | ARG419 |
| G | HOH692 |
| G | HOH731 |
| G | HOH744 |
| site_id | AI9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 507 |
| Chain | Residue |
| G | GLU168 |
| I | ARG165 |
| I | GLY166 |
| I | SER167 |
| site_id | AJ1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 508 |
| Chain | Residue |
| G | ARG85 |
| G | LYS86 |
| G | VAL87 |
| G | HOH617 |
| site_id | AJ2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN H 501 |
| Chain | Residue |
| H | LYS195 |
| H | ASP200 |
| H | ASP218 |
| H | GLU279 |
| H | ZN502 |
| H | BCT504 |
| H | HOH790 |
| site_id | AJ3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN H 502 |
| Chain | Residue |
| H | ASP200 |
| H | ASP277 |
| H | GLU279 |
| H | ZN501 |
| H | HOH790 |
| site_id | AJ4 |
| Number of Residues | 6 |
| Details | binding site for residue CA H 503 |
| Chain | Residue |
| H | THR113 |
| H | ILE114 |
| H | ALA116 |
| H | LYS216 |
| H | MET219 |
| H | HOH745 |
| site_id | AJ5 |
| Number of Residues | 8 |
| Details | binding site for residue BCT H 504 |
| Chain | Residue |
| H | LYS195 |
| H | ALA278 |
| H | GLU279 |
| H | GLY280 |
| H | ARG281 |
| H | LEU305 |
| H | ZN501 |
| H | HOH790 |
| site_id | AJ6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO H 505 |
| Chain | Residue |
| H | TRP72 |
| H | GLN76 |
| H | ASN339 |
| H | ARG419 |
| H | HOH654 |
| H | HOH789 |
| site_id | AJ7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 506 |
| Chain | Residue |
| H | ARG330 |
| H | ALA333 |
| H | HOH606 |
| site_id | AJ8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO H 507 |
| Chain | Residue |
| H | PRO296 |
| H | VAL385 |
| H | ASN387 |
| H | GLN390 |
| H | GLY391 |
| H | HOH619 |
| H | HOH768 |
| site_id | AJ9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO H 508 |
| Chain | Residue |
| H | GLU386 |
| H | ASN387 |
| H | TYR388 |
| H | GLN389 |
| site_id | AK1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO H 509 |
| Chain | Residue |
| H | THR143 |
| H | TYR144 |
| site_id | AK2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO H 510 |
| Chain | Residue |
| H | TRP75 |
| H | ARG85 |
| H | LYS86 |
| H | VAL87 |
| H | TRP89 |
| site_id | AK3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN I 501 |
| Chain | Residue |
| I | LYS195 |
| I | ASP200 |
| I | ASP218 |
| I | GLU279 |
| I | ZN502 |
| I | BCT506 |
| I | HOH803 |
| site_id | AK4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN I 502 |
| Chain | Residue |
| I | ASP200 |
| I | ASP277 |
| I | GLU279 |
| I | ZN501 |
| I | HOH803 |
| site_id | AK5 |
| Number of Residues | 7 |
| Details | binding site for residue CA I 503 |
| Chain | Residue |
| I | THR113 |
| I | ILE114 |
| I | ALA116 |
| I | LEU121 |
| I | LYS216 |
| I | MET219 |
| I | HOH801 |
| site_id | AK6 |
| Number of Residues | 6 |
| Details | binding site for residue CA I 504 |
| Chain | Residue |
| D | HOH672 |
| D | HOH725 |
| D | HOH797 |
| I | ASP151 |
| I | GLU154 |
| I | HOH838 |
| site_id | AK7 |
| Number of Residues | 5 |
| Details | binding site for residue BCT I 505 |
| Chain | Residue |
| D | GLN128 |
| D | ASP132 |
| D | TYR144 |
| I | ARG153 |
| I | GLU154 |
| site_id | AK8 |
| Number of Residues | 9 |
| Details | binding site for residue BCT I 506 |
| Chain | Residue |
| I | LYS195 |
| I | ASP277 |
| I | ALA278 |
| I | GLU279 |
| I | GLY280 |
| I | ARG281 |
| I | LEU305 |
| I | ZN501 |
| I | HOH803 |
| site_id | AK9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO I 507 |
| Chain | Residue |
| I | TRP72 |
| I | GLN76 |
| I | ASN339 |
| I | ARG419 |
| I | HOH694 |
| I | HOH824 |
| site_id | AL1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO I 508 |
| Chain | Residue |
| I | TRP75 |
| I | ARG85 |
| I | LYS86 |
| I | VAL87 |
| I | HOH653 |
| I | HOH697 |
| I | HOH731 |
| site_id | AL2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO I 509 |
| Chain | Residue |
| I | PRO296 |
| I | ASN387 |
| I | GLN390 |
| I | GLY391 |
| I | HOH719 |
| site_id | AL3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN J 501 |
| Chain | Residue |
| J | LYS195 |
| J | ASP200 |
| J | ASP218 |
| J | GLU279 |
| J | ZN502 |
| J | HOH651 |
| site_id | AL4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN J 502 |
| Chain | Residue |
| J | ASP200 |
| J | ASP277 |
| J | GLU279 |
| J | ZN501 |
| J | EDO506 |
| J | HOH651 |
| site_id | AL5 |
| Number of Residues | 6 |
| Details | binding site for residue CA J 503 |
| Chain | Residue |
| J | THR113 |
| J | ILE114 |
| J | ALA116 |
| J | LYS216 |
| J | MET219 |
| J | HOH700 |
| site_id | AL6 |
| Number of Residues | 7 |
| Details | binding site for residue BCT J 504 |
| Chain | Residue |
| J | LYS195 |
| J | ALA278 |
| J | GLU279 |
| J | GLY280 |
| J | ARG281 |
| J | LEU305 |
| J | HOH651 |
| site_id | AL7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO J 505 |
| Chain | Residue |
| J | TRP72 |
| J | GLN76 |
| J | ASN339 |
| J | ARG419 |
| J | HOH660 |
| J | HOH735 |
| J | HOH755 |
| site_id | AL8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO J 506 |
| Chain | Residue |
| J | ASP200 |
| J | LYS207 |
| J | THR304 |
| J | LEU305 |
| J | ZN502 |
| J | HOH651 |
| site_id | AL9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO J 507 |
| Chain | Residue |
| J | PRO296 |
| J | ASN387 |
| J | GLN390 |
| J | GLY391 |
| J | HOH633 |
| site_id | AM1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO J 508 |
| Chain | Residue |
| J | LYS79 |
| J | LEU104 |
| J | ASP108 |
| J | ASP112 |
| site_id | AM2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO J 509 |
| Chain | Residue |
| J | TRP75 |
| J | ARG85 |
| J | LYS86 |
| J | VAL87 |
| J | TRP89 |
| site_id | AM3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN K 501 |
| Chain | Residue |
| K | LYS195 |
| K | ASP200 |
| K | ASP218 |
| K | GLU279 |
| K | ZN502 |
| K | BCT505 |
| K | HOH714 |
| site_id | AM4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN K 502 |
| Chain | Residue |
| K | ASP200 |
| K | ASP277 |
| K | GLU279 |
| K | ZN501 |
| K | HOH714 |
| site_id | AM5 |
| Number of Residues | 6 |
| Details | binding site for residue CA K 503 |
| Chain | Residue |
| K | THR113 |
| K | ILE114 |
| K | ALA116 |
| K | LYS216 |
| K | MET219 |
| K | HOH806 |
| site_id | AM6 |
| Number of Residues | 6 |
| Details | binding site for residue CL K 504 |
| Chain | Residue |
| K | LYS269 |
| K | ARG352 |
| K | SER382 |
| K | HIS383 |
| K | TYR388 |
| K | HOH619 |
| site_id | AM7 |
| Number of Residues | 8 |
| Details | binding site for residue BCT K 505 |
| Chain | Residue |
| K | LYS195 |
| K | ALA278 |
| K | GLU279 |
| K | GLY280 |
| K | ARG281 |
| K | LEU305 |
| K | ZN501 |
| K | HOH714 |
| site_id | AM8 |
| Number of Residues | 6 |
| Details | binding site for residue BCT K 506 |
| Chain | Residue |
| K | ILE299 |
| K | ASN387 |
| K | GLN390 |
| K | GLY391 |
| K | HOH633 |
| K | HOH717 |
| site_id | AM9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO K 507 |
| Chain | Residue |
| K | TRP72 |
| K | GLN76 |
| K | ASN339 |
| K | ARG419 |
| K | HOH640 |
| K | HOH651 |
| K | HOH879 |
| site_id | AN1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO K 508 |
| Chain | Residue |
| K | TRP75 |
| K | ARG85 |
| K | LYS86 |
| K | VAL87 |
| K | TRP89 |
| K | HOH659 |
| K | HOH678 |
| K | HOH861 |
| site_id | AN2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN L 501 |
| Chain | Residue |
| L | LYS195 |
| L | ASP200 |
| L | ASP218 |
| L | GLU279 |
| L | ZN502 |
| L | BCT506 |
| L | HOH605 |
| site_id | AN3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN L 502 |
| Chain | Residue |
| L | ASP200 |
| L | ASP277 |
| L | GLU279 |
| L | ZN501 |
| L | EDO508 |
| L | HOH605 |
| site_id | AN4 |
| Number of Residues | 6 |
| Details | binding site for residue CA L 503 |
| Chain | Residue |
| L | THR113 |
| L | ILE114 |
| L | ALA116 |
| L | LYS216 |
| L | MET219 |
| L | HOH802 |
| site_id | AN5 |
| Number of Residues | 2 |
| Details | binding site for residue CL L 504 |
| Chain | Residue |
| L | GLY307 |
| L | ALA308 |
| site_id | AN6 |
| Number of Residues | 3 |
| Details | binding site for residue CL L 505 |
| Chain | Residue |
| L | LYS148 |
| L | SER170 |
| L | HOH880 |
| site_id | AN7 |
| Number of Residues | 9 |
| Details | binding site for residue BCT L 506 |
| Chain | Residue |
| L | LYS195 |
| L | ASP277 |
| L | ALA278 |
| L | GLU279 |
| L | GLY280 |
| L | ARG281 |
| L | LEU305 |
| L | ZN501 |
| L | HOH605 |
| site_id | AN8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO L 507 |
| Chain | Residue |
| L | TRP72 |
| L | GLN76 |
| L | ASN339 |
| L | ARG419 |
| L | HOH638 |
| L | HOH807 |
| site_id | AN9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO L 508 |
| Chain | Residue |
| L | ASP200 |
| L | LYS207 |
| L | THR304 |
| L | ZN502 |
| L | HOH605 |
| L | HOH777 |
| site_id | AO1 |
| Number of Residues | 3 |
| Details | binding site for residue PEG L 509 |
| Chain | Residue |
| L | GLN125 |
| L | ARG129 |
| L | HOH744 |
| site_id | AO2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO L 510 |
| Chain | Residue |
| L | TRP75 |
| L | ARG85 |
| L | VAL87 |
| L | TRP89 |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
| Chain | Residue | Details |
| A | ASN275-LEU282 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00504","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00504","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
