Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6O8B

Crystal structure of STING CTD in complex with TBK1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
A	0003676	molecular_function	nucleic acid binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0007249	biological_process	canonical NF-kappaB signal transduction
A	0009615	biological_process	response to virus
A	0010508	biological_process	positive regulation of autophagy
A	0010629	biological_process	negative regulation of gene expression
A	0016236	biological_process	macroautophagy
A	0016239	biological_process	positive regulation of macroautophagy
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0019903	molecular_function	protein phosphatase binding
A	0032008	biological_process	positive regulation of TOR signaling
A	0032479	biological_process	regulation of type I interferon production
A	0032481	biological_process	positive regulation of type I interferon production
A	0032727	biological_process	positive regulation of interferon-alpha production
A	0032728	biological_process	positive regulation of interferon-beta production
A	0034142	biological_process	toll-like receptor 4 signaling pathway
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0045087	biological_process	innate immune response
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051219	molecular_function	phosphoprotein binding
A	0051607	biological_process	defense response to virus
A	0051707	biological_process	response to other organism
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0060340	biological_process	positive regulation of type I interferon-mediated signaling pathway
A	0061470	biological_process	T follicular helper cell differentiation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0106310	molecular_function	protein serine kinase activity
A	0140374	biological_process	antiviral innate immune response
A	0140896	biological_process	cGAS/STING signaling pathway
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1904417	biological_process	positive regulation of xenophagy
A	1904515	biological_process	positive regulation of TORC2 signaling
B	0000166	molecular_function	nucleotide binding
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
B	0003676	molecular_function	nucleic acid binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006468	biological_process	protein phosphorylation
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0007249	biological_process	canonical NF-kappaB signal transduction
B	0009615	biological_process	response to virus
B	0010508	biological_process	positive regulation of autophagy
B	0010629	biological_process	negative regulation of gene expression
B	0016236	biological_process	macroautophagy
B	0016239	biological_process	positive regulation of macroautophagy
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0018105	biological_process	peptidyl-serine phosphorylation
B	0018107	biological_process	peptidyl-threonine phosphorylation
B	0019903	molecular_function	protein phosphatase binding
B	0032008	biological_process	positive regulation of TOR signaling
B	0032479	biological_process	regulation of type I interferon production
B	0032481	biological_process	positive regulation of type I interferon production
B	0032727	biological_process	positive regulation of interferon-alpha production
B	0032728	biological_process	positive regulation of interferon-beta production
B	0034142	biological_process	toll-like receptor 4 signaling pathway
B	0042802	molecular_function	identical protein binding
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0045087	biological_process	innate immune response
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051219	molecular_function	phosphoprotein binding
B	0051607	biological_process	defense response to virus
B	0051707	biological_process	response to other organism
B	0060337	biological_process	type I interferon-mediated signaling pathway
B	0060340	biological_process	positive regulation of type I interferon-mediated signaling pathway
B	0061470	biological_process	T follicular helper cell differentiation
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0106310	molecular_function	protein serine kinase activity
B	0140374	biological_process	antiviral innate immune response
B	0140896	biological_process	cGAS/STING signaling pathway
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1904417	biological_process	positive regulation of xenophagy
B	1904515	biological_process	positive regulation of TORC2 signaling
D	0002218	biological_process	activation of innate immune response
D	0032481	biological_process	positive regulation of type I interferon production
E	0002218	biological_process	activation of innate immune response
E	0032481	biological_process	positive regulation of type I interferon production

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue BX7 A 701

Chain	Residue
A	LEU15
A	SER93
A	THR96
A	GLY139
A	MET142
A	THR156
A	GLN17
A	ALA36
A	LYS38
A	MET86
A	GLU87
A	PHE88
A	CYS89
A	GLY92

site_id	AC2
Number of Residues	17
Details	binding site for residue BX7 B 701

Chain	Residue
B	LEU15
B	GLY16
B	GLN17
B	GLY18
B	VAL23
B	ALA36
B	LYS38
B	MET86
B	PHE88
B	CYS89
B	GLY92
B	SER93
B	TYR95
B	GLY139
B	MET142
B	THR156
B	ASP157

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........FAIK

Chain	Residue	Details
A	LEU15-LYS38

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	602
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	152
Details	Domain: {"description":"Ubiquitin-like"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"23453971","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23453972","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30842653","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis and IKKB","evidences":[{"source":"PubMed","id":"11839743","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22851595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; by SETD4","evidences":[{"source":"PubMed","id":"37926288","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23453971","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)