Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6O7T

Saccharomyces cerevisiae V-ATPase Vph1-VO

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0000324	cellular_component	fungal-type vacuole
a	0000329	cellular_component	fungal-type vacuole membrane
a	0005515	molecular_function	protein binding
a	0005774	cellular_component	vacuolar membrane
a	0006797	biological_process	polyphosphate metabolic process
a	0006811	biological_process	monoatomic ion transport
a	0007035	biological_process	vacuolar acidification
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0045121	cellular_component	membrane raft
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0051117	molecular_function	ATPase binding
a	0065003	biological_process	protein-containing complex assembly
a	0071469	biological_process	cellular response to alkaline pH
a	0071474	biological_process	cellular hyperosmotic response
a	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
a	1902600	biological_process	proton transmembrane transport
a	1903778	biological_process	protein localization to vacuolar membrane
c	0000139	cellular_component	Golgi membrane
c	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
c	0000329	cellular_component	fungal-type vacuole membrane
c	0005515	molecular_function	protein binding
c	0005774	cellular_component	vacuolar membrane
c	0006811	biological_process	monoatomic ion transport
c	0007035	biological_process	vacuolar acidification
c	0008553	molecular_function	P-type proton-exporting transporter activity
c	0015078	molecular_function	proton transmembrane transporter activity
c	0016020	cellular_component	membrane
c	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
c	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
c	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	0048388	biological_process	endosomal lumen acidification
c	0061795	biological_process	Golgi lumen acidification
c	1902600	biological_process	proton transmembrane transport
d	0000139	cellular_component	Golgi membrane
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0000329	cellular_component	fungal-type vacuole membrane
d	0005515	molecular_function	protein binding
d	0005774	cellular_component	vacuolar membrane
d	0006811	biological_process	monoatomic ion transport
d	0007034	biological_process	vacuolar transport
d	0007035	biological_process	vacuolar acidification
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0048388	biological_process	endosomal lumen acidification
d	0061795	biological_process	Golgi lumen acidification
d	1902600	biological_process	proton transmembrane transport
e	0000032	biological_process	cell wall mannoprotein biosynthetic process
e	0000139	cellular_component	Golgi membrane
e	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
e	0000329	cellular_component	fungal-type vacuole membrane
e	0005774	cellular_component	vacuolar membrane
e	0006811	biological_process	monoatomic ion transport
e	0007035	biological_process	vacuolar acidification
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0048388	biological_process	endosomal lumen acidification
e	0055085	biological_process	transmembrane transport
e	0061795	biological_process	Golgi lumen acidification
e	0065003	biological_process	protein-containing complex assembly
e	1902600	biological_process	proton transmembrane transport
f	0000139	cellular_component	Golgi membrane
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0000329	cellular_component	fungal-type vacuole membrane
f	0003674	molecular_function	molecular_function
f	0004521	molecular_function	RNA endonuclease activity
f	0005575	cellular_component	cellular_component
f	0005774	cellular_component	vacuolar membrane
f	0005789	cellular_component	endoplasmic reticulum membrane
f	0007035	biological_process	vacuolar acidification
f	0008150	biological_process	biological_process
f	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
f	0048388	biological_process	endosomal lumen acidification
f	0061795	biological_process	Golgi lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport
g	0000139	cellular_component	Golgi membrane
g	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
g	0000329	cellular_component	fungal-type vacuole membrane
g	0005515	molecular_function	protein binding
g	0005774	cellular_component	vacuolar membrane
g	0006623	biological_process	protein targeting to vacuole
g	0006811	biological_process	monoatomic ion transport
g	0006878	biological_process	intracellular copper ion homeostasis
g	0006879	biological_process	intracellular iron ion homeostasis
g	0006897	biological_process	endocytosis
g	0007033	biological_process	vacuole organization
g	0007035	biological_process	vacuolar acidification
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016020	cellular_component	membrane
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0048388	biological_process	endosomal lumen acidification
g	0061795	biological_process	Golgi lumen acidification
g	1902600	biological_process	proton transmembrane transport
h	0000139	cellular_component	Golgi membrane
h	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
h	0000329	cellular_component	fungal-type vacuole membrane
h	0005515	molecular_function	protein binding
h	0005774	cellular_component	vacuolar membrane
h	0006623	biological_process	protein targeting to vacuole
h	0006811	biological_process	monoatomic ion transport
h	0006878	biological_process	intracellular copper ion homeostasis
h	0006879	biological_process	intracellular iron ion homeostasis
h	0006897	biological_process	endocytosis
h	0007033	biological_process	vacuole organization
h	0007035	biological_process	vacuolar acidification
h	0015078	molecular_function	proton transmembrane transporter activity
h	0016020	cellular_component	membrane
h	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
h	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
h	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
h	0048388	biological_process	endosomal lumen acidification
h	0061795	biological_process	Golgi lumen acidification
h	1902600	biological_process	proton transmembrane transport
i	0000139	cellular_component	Golgi membrane
i	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
i	0000329	cellular_component	fungal-type vacuole membrane
i	0005515	molecular_function	protein binding
i	0005774	cellular_component	vacuolar membrane
i	0006623	biological_process	protein targeting to vacuole
i	0006811	biological_process	monoatomic ion transport
i	0006878	biological_process	intracellular copper ion homeostasis
i	0006879	biological_process	intracellular iron ion homeostasis
i	0006897	biological_process	endocytosis
i	0007033	biological_process	vacuole organization
i	0007035	biological_process	vacuolar acidification
i	0015078	molecular_function	proton transmembrane transporter activity
i	0016020	cellular_component	membrane
i	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
i	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
i	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
i	0048388	biological_process	endosomal lumen acidification
i	0061795	biological_process	Golgi lumen acidification
i	1902600	biological_process	proton transmembrane transport
j	0000139	cellular_component	Golgi membrane
j	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
j	0000329	cellular_component	fungal-type vacuole membrane
j	0005515	molecular_function	protein binding
j	0005774	cellular_component	vacuolar membrane
j	0006623	biological_process	protein targeting to vacuole
j	0006811	biological_process	monoatomic ion transport
j	0006878	biological_process	intracellular copper ion homeostasis
j	0006879	biological_process	intracellular iron ion homeostasis
j	0006897	biological_process	endocytosis
j	0007033	biological_process	vacuole organization
j	0007035	biological_process	vacuolar acidification
j	0015078	molecular_function	proton transmembrane transporter activity
j	0016020	cellular_component	membrane
j	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
j	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
j	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
j	0048388	biological_process	endosomal lumen acidification
j	0061795	biological_process	Golgi lumen acidification
j	1902600	biological_process	proton transmembrane transport
k	0000139	cellular_component	Golgi membrane
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0000329	cellular_component	fungal-type vacuole membrane
k	0005515	molecular_function	protein binding
k	0005774	cellular_component	vacuolar membrane
k	0006623	biological_process	protein targeting to vacuole
k	0006811	biological_process	monoatomic ion transport
k	0006878	biological_process	intracellular copper ion homeostasis
k	0006879	biological_process	intracellular iron ion homeostasis
k	0006897	biological_process	endocytosis
k	0007033	biological_process	vacuole organization
k	0007035	biological_process	vacuolar acidification
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	0048388	biological_process	endosomal lumen acidification
k	0061795	biological_process	Golgi lumen acidification
k	1902600	biological_process	proton transmembrane transport
l	0000139	cellular_component	Golgi membrane
l	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
l	0000329	cellular_component	fungal-type vacuole membrane
l	0005515	molecular_function	protein binding
l	0005774	cellular_component	vacuolar membrane
l	0006623	biological_process	protein targeting to vacuole
l	0006811	biological_process	monoatomic ion transport
l	0006878	biological_process	intracellular copper ion homeostasis
l	0006879	biological_process	intracellular iron ion homeostasis
l	0006897	biological_process	endocytosis
l	0007033	biological_process	vacuole organization
l	0007035	biological_process	vacuolar acidification
l	0015078	molecular_function	proton transmembrane transporter activity
l	0016020	cellular_component	membrane
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	0048388	biological_process	endosomal lumen acidification
l	0061795	biological_process	Golgi lumen acidification
l	1902600	biological_process	proton transmembrane transport
m	0000139	cellular_component	Golgi membrane
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0000329	cellular_component	fungal-type vacuole membrane
m	0005515	molecular_function	protein binding
m	0005774	cellular_component	vacuolar membrane
m	0006623	biological_process	protein targeting to vacuole
m	0006811	biological_process	monoatomic ion transport
m	0006878	biological_process	intracellular copper ion homeostasis
m	0006879	biological_process	intracellular iron ion homeostasis
m	0006897	biological_process	endocytosis
m	0007033	biological_process	vacuole organization
m	0007035	biological_process	vacuolar acidification
m	0015078	molecular_function	proton transmembrane transporter activity
m	0016020	cellular_component	membrane
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	0048388	biological_process	endosomal lumen acidification
m	0061795	biological_process	Golgi lumen acidification
m	1902600	biological_process	proton transmembrane transport
n	0000139	cellular_component	Golgi membrane
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0000329	cellular_component	fungal-type vacuole membrane
n	0005515	molecular_function	protein binding
n	0005774	cellular_component	vacuolar membrane
n	0006623	biological_process	protein targeting to vacuole
n	0006811	biological_process	monoatomic ion transport
n	0006878	biological_process	intracellular copper ion homeostasis
n	0006879	biological_process	intracellular iron ion homeostasis
n	0006897	biological_process	endocytosis
n	0007033	biological_process	vacuole organization
n	0007035	biological_process	vacuolar acidification
n	0015078	molecular_function	proton transmembrane transporter activity
n	0016020	cellular_component	membrane
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	0048388	biological_process	endosomal lumen acidification
n	0061795	biological_process	Golgi lumen acidification
n	1902600	biological_process	proton transmembrane transport
o	0000139	cellular_component	Golgi membrane
o	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
o	0000324	cellular_component	fungal-type vacuole
o	0000329	cellular_component	fungal-type vacuole membrane
o	0005774	cellular_component	vacuolar membrane
o	0006811	biological_process	monoatomic ion transport
o	0007035	biological_process	vacuolar acidification
o	0015078	molecular_function	proton transmembrane transporter activity
o	0016020	cellular_component	membrane
o	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
o	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
o	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
o	0048388	biological_process	endosomal lumen acidification
o	0061795	biological_process	Golgi lumen acidification
o	0071944	cellular_component	cell periphery
o	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1096
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	263
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	318
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	28
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	65
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	34
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"9030535","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30910982","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30910982","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"1825730","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)