6O77
Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, calcium-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0030001 | biological_process | metal ion transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0099604 | molecular_function | ligand-gated calcium channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019722 | biological_process | calcium-mediated signaling |
| B | 0030001 | biological_process | metal ion transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0099604 | molecular_function | ligand-gated calcium channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019722 | biological_process | calcium-mediated signaling |
| C | 0030001 | biological_process | metal ion transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0098655 | biological_process | monoatomic cation transmembrane transport |
| C | 0099604 | molecular_function | ligand-gated calcium channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0019722 | biological_process | calcium-mediated signaling |
| D | 0030001 | biological_process | metal ion transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0098655 | biological_process | monoatomic cation transmembrane transport |
| D | 0099604 | molecular_function | ligand-gated calcium channel activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 1401 |
| Chain | Residue |
| A | GLU773 |
| A | GLN776 |
| A | ASN790 |
| A | ASP793 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 A 1402 |
| Chain | Residue |
| A | SER840 |
| A | ARG841 |
| A | Y011403 |
| A | TRP673 |
| A | PHE729 |
| A | ILE734 |
| A | PHE837 |
| A | VAL839 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 A 1403 |
| Chain | Residue |
| A | TYR826 |
| A | PHE837 |
| A | ASN842 |
| A | Y011402 |
| D | PHE862 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 A 1404 |
| Chain | Residue |
| A | GLU887 |
| A | ARG891 |
| D | PRO942 |
| D | GLU943 |
| D | TRP944 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 1401 |
| Chain | Residue |
| B | GLU773 |
| B | GLN776 |
| B | ASN790 |
| B | ASP793 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 B 1402 |
| Chain | Residue |
| B | TRP673 |
| B | PHE729 |
| B | ILE734 |
| B | PHE837 |
| B | VAL839 |
| B | SER840 |
| B | ARG841 |
| B | Y011403 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 B 1403 |
| Chain | Residue |
| A | PHE862 |
| B | TYR826 |
| B | PHE837 |
| B | ASN842 |
| B | Y011402 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 B 1404 |
| Chain | Residue |
| A | PRO942 |
| A | GLU943 |
| A | TRP944 |
| B | GLU887 |
| B | ARG891 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 1401 |
| Chain | Residue |
| C | GLU773 |
| C | GLN776 |
| C | ASN790 |
| C | ASP793 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 C 1402 |
| Chain | Residue |
| C | TRP673 |
| C | PHE729 |
| C | ILE734 |
| C | PHE837 |
| C | VAL839 |
| C | SER840 |
| C | ARG841 |
| C | Y011403 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 C 1403 |
| Chain | Residue |
| B | PHE862 |
| C | TYR826 |
| C | PHE837 |
| C | ASN842 |
| C | Y011402 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 C 1404 |
| Chain | Residue |
| B | PRO942 |
| B | GLU943 |
| B | TRP944 |
| C | GLU887 |
| C | ARG891 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue CA D 1401 |
| Chain | Residue |
| D | GLU773 |
| D | GLN776 |
| D | ASN790 |
| D | ASP793 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 D 1402 |
| Chain | Residue |
| D | TRP673 |
| D | PHE729 |
| D | ILE734 |
| D | PHE837 |
| D | VAL839 |
| D | SER840 |
| D | ARG841 |
| D | Y011403 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 D 1403 |
| Chain | Residue |
| C | PHE862 |
| D | TYR826 |
| D | PHE837 |
| D | ASN842 |
| D | Y011402 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 D 1404 |
| Chain | Residue |
| C | PRO942 |
| C | GLU943 |
| C | TRP944 |
| D | GLU887 |
| D | ARG891 |
