6O77

Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, calcium-bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0019722	biological_process	calcium-mediated signaling
A	0030001	biological_process	metal ion transport
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0099604	molecular_function	ligand-gated calcium channel activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0019722	biological_process	calcium-mediated signaling
B	0030001	biological_process	metal ion transport
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0099604	molecular_function	ligand-gated calcium channel activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0019722	biological_process	calcium-mediated signaling
C	0030001	biological_process	metal ion transport
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0099604	molecular_function	ligand-gated calcium channel activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0019722	biological_process	calcium-mediated signaling
D	0030001	biological_process	metal ion transport
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0099604	molecular_function	ligand-gated calcium channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 1401

Chain	Residue
A	GLU773
A	GLN776
A	ASN790
A	ASP793

---

site_id	AC2
Number of Residues	8
Details	binding site for residue Y01 A 1402

Chain	Residue
A	SER840
A	ARG841
A	Y011403
A	TRP673
A	PHE729
A	ILE734
A	PHE837
A	VAL839

---

site_id	AC3
Number of Residues	5
Details	binding site for residue Y01 A 1403

Chain	Residue
A	TYR826
A	PHE837
A	ASN842
A	Y011402
D	PHE862

---

site_id	AC4
Number of Residues	5
Details	binding site for residue Y01 A 1404

Chain	Residue
A	GLU887
A	ARG891
D	PRO942
D	GLU943
D	TRP944

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CA B 1401

Chain	Residue
B	GLU773
B	GLN776
B	ASN790
B	ASP793

---

site_id	AC6
Number of Residues	8
Details	binding site for residue Y01 B 1402

Chain	Residue
B	TRP673
B	PHE729
B	ILE734
B	PHE837
B	VAL839
B	SER840
B	ARG841
B	Y011403

---

site_id	AC7
Number of Residues	5
Details	binding site for residue Y01 B 1403

Chain	Residue
A	PHE862
B	TYR826
B	PHE837
B	ASN842
B	Y011402

---

site_id	AC8
Number of Residues	5
Details	binding site for residue Y01 B 1404

Chain	Residue
A	PRO942
A	GLU943
A	TRP944
B	GLU887
B	ARG891

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CA C 1401

Chain	Residue
C	GLU773
C	GLN776
C	ASN790
C	ASP793

---

site_id	AD1
Number of Residues	8
Details	binding site for residue Y01 C 1402

Chain	Residue
C	TRP673
C	PHE729
C	ILE734
C	PHE837
C	VAL839
C	SER840
C	ARG841
C	Y011403

---

site_id	AD2
Number of Residues	5
Details	binding site for residue Y01 C 1403

Chain	Residue
B	PHE862
C	TYR826
C	PHE837
C	ASN842
C	Y011402

---

site_id	AD3
Number of Residues	5
Details	binding site for residue Y01 C 1404

Chain	Residue
B	PRO942
B	GLU943
B	TRP944
C	GLU887
C	ARG891

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CA D 1401

Chain	Residue
D	GLU773
D	GLN776
D	ASN790
D	ASP793

---

site_id	AD5
Number of Residues	8
Details	binding site for residue Y01 D 1402

Chain	Residue
D	TRP673
D	PHE729
D	ILE734
D	PHE837
D	VAL839
D	SER840
D	ARG841
D	Y011403

---

site_id	AD6
Number of Residues	5
Details	binding site for residue Y01 D 1403

Chain	Residue
C	PHE862
D	TYR826
D	PHE837
D	ASN842
D	Y011402

---

site_id	AD7
Number of Residues	5
Details	binding site for residue Y01 D 1404

Chain	Residue
C	PRO942
C	GLU943
C	TRP944
D	GLU887
D	ARG891

---