6O6R

Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0019722	biological_process	calcium-mediated signaling
A	0030001	biological_process	metal ion transport
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0099604	molecular_function	ligand-gated calcium channel activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0019722	biological_process	calcium-mediated signaling
B	0030001	biological_process	metal ion transport
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0099604	molecular_function	ligand-gated calcium channel activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0019722	biological_process	calcium-mediated signaling
C	0030001	biological_process	metal ion transport
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0099604	molecular_function	ligand-gated calcium channel activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0019722	biological_process	calcium-mediated signaling
D	0030001	biological_process	metal ion transport
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0099604	molecular_function	ligand-gated calcium channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue UND A 1302

Chain	Residue
A	MET688
A	PHE691
A	9PE1303

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site_id	AC2
Number of Residues	9
Details	binding site for residue LQ7 A 1305

Chain	Residue
A	ARG832
A	ILE836
A	ARG998
A	PHE729
A	ASN732
A	TYR736
A	GLU773
A	ASP793
A	PHE829

---

site_id	AC3
Number of Residues	1
Details	binding site for residue NA A 1307

Chain	Residue
A	TRP867

---

site_id	AC4
Number of Residues	1
Details	binding site for residue UND B 1304

Chain	Residue
A	TYR953

---

site_id	AC5
Number of Residues	9
Details	binding site for residue LQ7 B 1305

Chain	Residue
B	PHE729
B	ASN732
B	TYR736
B	GLU773
B	ASP793
B	PHE829
B	ARG832
B	ILE836
B	ARG998

---

site_id	AC6
Number of Residues	1
Details	binding site for residue NA B 1307

Chain	Residue
B	TRP867

---

site_id	AC7
Number of Residues	2
Details	binding site for residue UND C 1304

Chain	Residue
B	TYR953
B	THR957

---

site_id	AC8
Number of Residues	9
Details	binding site for residue LQ7 C 1305

Chain	Residue
C	PHE729
C	ASN732
C	TYR736
C	GLU773
C	ASP793
C	PHE829
C	ARG832
C	ILE836
C	ARG998

---

site_id	AC9
Number of Residues	1
Details	binding site for residue NA C 1307

Chain	Residue
C	TRP867

---

site_id	AD1
Number of Residues	9
Details	binding site for residue LQ7 D 1305

Chain	Residue
D	PHE729
D	ASN732
D	TYR736
D	GLU773
D	ASP793
D	PHE829
D	ARG832
D	ILE836
D	ARG998

---

site_id	AD2
Number of Residues	1
Details	binding site for residue NA D 1307

Chain	Residue
D	TRP867

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