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6O58

Human MCU-EMRE complex, dimer of channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0006851biological_processmitochondrial calcium ion transmembrane transport
A0015292molecular_functionuniporter activity
A0019722biological_processcalcium-mediated signaling
A0032024biological_processpositive regulation of insulin secretion
A0034704cellular_componentcalcium channel complex
A0036444biological_processcalcium import into the mitochondrion
A0042593biological_processglucose homeostasis
A0051259biological_processprotein complex oligomerization
A0051560biological_processmitochondrial calcium ion homeostasis
A0051561biological_processpositive regulation of mitochondrial calcium ion concentration
A0070588biological_processcalcium ion transmembrane transport
A0072732biological_processcellular response to calcium ion starvation
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0090141biological_processpositive regulation of mitochondrial fission
A0090527biological_processobsolete actin filament reorganization
A1990246cellular_componentuniplex complex
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0006816biological_processcalcium ion transport
B0006851biological_processmitochondrial calcium ion transmembrane transport
B0030674molecular_functionprotein-macromolecule adaptor activity
B0036444biological_processcalcium import into the mitochondrion
B0051560biological_processmitochondrial calcium ion homeostasis
B0072732biological_processcellular response to calcium ion starvation
B0099103molecular_functionchannel activator activity
B1990246cellular_componentuniplex complex
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0006851biological_processmitochondrial calcium ion transmembrane transport
C0015292molecular_functionuniporter activity
C0019722biological_processcalcium-mediated signaling
C0032024biological_processpositive regulation of insulin secretion
C0034704cellular_componentcalcium channel complex
C0036444biological_processcalcium import into the mitochondrion
C0042593biological_processglucose homeostasis
C0051259biological_processprotein complex oligomerization
C0051560biological_processmitochondrial calcium ion homeostasis
C0051561biological_processpositive regulation of mitochondrial calcium ion concentration
C0070588biological_processcalcium ion transmembrane transport
C0072732biological_processcellular response to calcium ion starvation
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0090141biological_processpositive regulation of mitochondrial fission
C0090527biological_processobsolete actin filament reorganization
C1990246cellular_componentuniplex complex
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0006816biological_processcalcium ion transport
D0006851biological_processmitochondrial calcium ion transmembrane transport
D0030674molecular_functionprotein-macromolecule adaptor activity
D0036444biological_processcalcium import into the mitochondrion
D0051560biological_processmitochondrial calcium ion homeostasis
D0072732biological_processcellular response to calcium ion starvation
D0099103molecular_functionchannel activator activity
D1990246cellular_componentuniplex complex
E0005262molecular_functioncalcium channel activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0005743cellular_componentmitochondrial inner membrane
E0006851biological_processmitochondrial calcium ion transmembrane transport
E0015292molecular_functionuniporter activity
E0019722biological_processcalcium-mediated signaling
E0032024biological_processpositive regulation of insulin secretion
E0034704cellular_componentcalcium channel complex
E0036444biological_processcalcium import into the mitochondrion
E0042593biological_processglucose homeostasis
E0051259biological_processprotein complex oligomerization
E0051560biological_processmitochondrial calcium ion homeostasis
E0051561biological_processpositive regulation of mitochondrial calcium ion concentration
E0070588biological_processcalcium ion transmembrane transport
E0072732biological_processcellular response to calcium ion starvation
E0090023biological_processpositive regulation of neutrophil chemotaxis
E0090141biological_processpositive regulation of mitochondrial fission
E0090527biological_processobsolete actin filament reorganization
E1990246cellular_componentuniplex complex
F0005515molecular_functionprotein binding
F0005654cellular_componentnucleoplasm
F0005739cellular_componentmitochondrion
F0005743cellular_componentmitochondrial inner membrane
F0005759cellular_componentmitochondrial matrix
F0006816biological_processcalcium ion transport
F0006851biological_processmitochondrial calcium ion transmembrane transport
F0030674molecular_functionprotein-macromolecule adaptor activity
F0036444biological_processcalcium import into the mitochondrion
F0051560biological_processmitochondrial calcium ion homeostasis
F0072732biological_processcellular response to calcium ion starvation
F0099103molecular_functionchannel activator activity
F1990246cellular_componentuniplex complex
G0005262molecular_functioncalcium channel activity
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005743cellular_componentmitochondrial inner membrane
G0006851biological_processmitochondrial calcium ion transmembrane transport
G0015292molecular_functionuniporter activity
G0019722biological_processcalcium-mediated signaling
G0032024biological_processpositive regulation of insulin secretion
G0034704cellular_componentcalcium channel complex
G0036444biological_processcalcium import into the mitochondrion
G0042593biological_processglucose homeostasis
G0051259biological_processprotein complex oligomerization
G0051560biological_processmitochondrial calcium ion homeostasis
G0051561biological_processpositive regulation of mitochondrial calcium ion concentration
G0070588biological_processcalcium ion transmembrane transport
G0072732biological_processcellular response to calcium ion starvation
G0090023biological_processpositive regulation of neutrophil chemotaxis
G0090141biological_processpositive regulation of mitochondrial fission
G0090527biological_processobsolete actin filament reorganization
G1990246cellular_componentuniplex complex
H0005515molecular_functionprotein binding
H0005654cellular_componentnucleoplasm
H0005739cellular_componentmitochondrion
H0005743cellular_componentmitochondrial inner membrane
H0005759cellular_componentmitochondrial matrix
H0006816biological_processcalcium ion transport
H0006851biological_processmitochondrial calcium ion transmembrane transport
H0030674molecular_functionprotein-macromolecule adaptor activity
H0036444biological_processcalcium import into the mitochondrion
H0051560biological_processmitochondrial calcium ion homeostasis
H0072732biological_processcellular response to calcium ion starvation
H0099103molecular_functionchannel activator activity
H1990246cellular_componentuniplex complex
I0005262molecular_functioncalcium channel activity
I0005515molecular_functionprotein binding
I0005739cellular_componentmitochondrion
I0005743cellular_componentmitochondrial inner membrane
I0006851biological_processmitochondrial calcium ion transmembrane transport
I0015292molecular_functionuniporter activity
I0019722biological_processcalcium-mediated signaling
I0032024biological_processpositive regulation of insulin secretion
I0034704cellular_componentcalcium channel complex
I0036444biological_processcalcium import into the mitochondrion
I0042593biological_processglucose homeostasis
I0051259biological_processprotein complex oligomerization
I0051560biological_processmitochondrial calcium ion homeostasis
I0051561biological_processpositive regulation of mitochondrial calcium ion concentration
I0070588biological_processcalcium ion transmembrane transport
I0072732biological_processcellular response to calcium ion starvation
I0090023biological_processpositive regulation of neutrophil chemotaxis
I0090141biological_processpositive regulation of mitochondrial fission
I0090527biological_processobsolete actin filament reorganization
I1990246cellular_componentuniplex complex
J0005515molecular_functionprotein binding
J0005654cellular_componentnucleoplasm
J0005739cellular_componentmitochondrion
J0005743cellular_componentmitochondrial inner membrane
J0005759cellular_componentmitochondrial matrix
J0006816biological_processcalcium ion transport
J0006851biological_processmitochondrial calcium ion transmembrane transport
J0030674molecular_functionprotein-macromolecule adaptor activity
J0036444biological_processcalcium import into the mitochondrion
J0051560biological_processmitochondrial calcium ion homeostasis
J0072732biological_processcellular response to calcium ion starvation
J0099103molecular_functionchannel activator activity
J1990246cellular_componentuniplex complex
K0005262molecular_functioncalcium channel activity
K0005515molecular_functionprotein binding
K0005739cellular_componentmitochondrion
K0005743cellular_componentmitochondrial inner membrane
K0006851biological_processmitochondrial calcium ion transmembrane transport
K0015292molecular_functionuniporter activity
K0019722biological_processcalcium-mediated signaling
K0032024biological_processpositive regulation of insulin secretion
K0034704cellular_componentcalcium channel complex
K0036444biological_processcalcium import into the mitochondrion
K0042593biological_processglucose homeostasis
K0051259biological_processprotein complex oligomerization
K0051560biological_processmitochondrial calcium ion homeostasis
K0051561biological_processpositive regulation of mitochondrial calcium ion concentration
K0070588biological_processcalcium ion transmembrane transport
K0072732biological_processcellular response to calcium ion starvation
K0090023biological_processpositive regulation of neutrophil chemotaxis
K0090141biological_processpositive regulation of mitochondrial fission
K0090527biological_processobsolete actin filament reorganization
K1990246cellular_componentuniplex complex
L0005515molecular_functionprotein binding
L0005654cellular_componentnucleoplasm
L0005739cellular_componentmitochondrion
L0005743cellular_componentmitochondrial inner membrane
L0005759cellular_componentmitochondrial matrix
L0006816biological_processcalcium ion transport
L0006851biological_processmitochondrial calcium ion transmembrane transport
L0030674molecular_functionprotein-macromolecule adaptor activity
L0036444biological_processcalcium import into the mitochondrion
L0051560biological_processmitochondrial calcium ion homeostasis
L0072732biological_processcellular response to calcium ion starvation
L0099103molecular_functionchannel activator activity
L1990246cellular_componentuniplex complex
M0005262molecular_functioncalcium channel activity
M0005515molecular_functionprotein binding
M0005739cellular_componentmitochondrion
M0005743cellular_componentmitochondrial inner membrane
M0006851biological_processmitochondrial calcium ion transmembrane transport
M0015292molecular_functionuniporter activity
M0019722biological_processcalcium-mediated signaling
M0032024biological_processpositive regulation of insulin secretion
M0034704cellular_componentcalcium channel complex
M0036444biological_processcalcium import into the mitochondrion
M0042593biological_processglucose homeostasis
M0051259biological_processprotein complex oligomerization
M0051560biological_processmitochondrial calcium ion homeostasis
M0051561biological_processpositive regulation of mitochondrial calcium ion concentration
M0070588biological_processcalcium ion transmembrane transport
M0072732biological_processcellular response to calcium ion starvation
M0090023biological_processpositive regulation of neutrophil chemotaxis
M0090141biological_processpositive regulation of mitochondrial fission
M0090527biological_processobsolete actin filament reorganization
M1990246cellular_componentuniplex complex
N0005515molecular_functionprotein binding
N0005654cellular_componentnucleoplasm
N0005739cellular_componentmitochondrion
N0005743cellular_componentmitochondrial inner membrane
N0005759cellular_componentmitochondrial matrix
N0006816biological_processcalcium ion transport
N0006851biological_processmitochondrial calcium ion transmembrane transport
N0030674molecular_functionprotein-macromolecule adaptor activity
N0036444biological_processcalcium import into the mitochondrion
N0051560biological_processmitochondrial calcium ion homeostasis
N0072732biological_processcellular response to calcium ion starvation
N0099103molecular_functionchannel activator activity
N1990246cellular_componentuniplex complex
O0005262molecular_functioncalcium channel activity
O0005515molecular_functionprotein binding
O0005739cellular_componentmitochondrion
O0005743cellular_componentmitochondrial inner membrane
O0006851biological_processmitochondrial calcium ion transmembrane transport
O0015292molecular_functionuniporter activity
O0019722biological_processcalcium-mediated signaling
O0032024biological_processpositive regulation of insulin secretion
O0034704cellular_componentcalcium channel complex
O0036444biological_processcalcium import into the mitochondrion
O0042593biological_processglucose homeostasis
O0051259biological_processprotein complex oligomerization
O0051560biological_processmitochondrial calcium ion homeostasis
O0051561biological_processpositive regulation of mitochondrial calcium ion concentration
O0070588biological_processcalcium ion transmembrane transport
O0072732biological_processcellular response to calcium ion starvation
O0090023biological_processpositive regulation of neutrophil chemotaxis
O0090141biological_processpositive regulation of mitochondrial fission
O0090527biological_processobsolete actin filament reorganization
O1990246cellular_componentuniplex complex
P0005515molecular_functionprotein binding
P0005654cellular_componentnucleoplasm
P0005739cellular_componentmitochondrion
P0005743cellular_componentmitochondrial inner membrane
P0005759cellular_componentmitochondrial matrix
P0006816biological_processcalcium ion transport
P0006851biological_processmitochondrial calcium ion transmembrane transport
P0030674molecular_functionprotein-macromolecule adaptor activity
P0036444biological_processcalcium import into the mitochondrion
P0051560biological_processmitochondrial calcium ion homeostasis
P0072732biological_processcellular response to calcium ion starvation
P0099103molecular_functionchannel activator activity
P1990246cellular_componentuniplex complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue CA I 401
ChainResidue
IGLU264
KGLU264
MGLU264
OGLU264

site_idAC2
Number of Residues4
Detailsbinding site for residue CA A 401
ChainResidue
AGLU264
CGLU264
EGLU264
GGLU264

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsTOPO_DOM: Mitochondrial matrix => ECO:0000305|PubMed:27099988, ECO:0000305|PubMed:27642048
ChainResidueDetails
LSER53-SER64
PSER53-SER64
NSER53-SER64
HSER53-SER64
JSER53-SER64
DSER53-SER64
BSER53-SER64
FSER53-SER64

site_idSWS_FT_FI2
Number of Residues152
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
LPHE65-ILE84
IVAL266-VAL283
CLEU234-TRP256
CVAL266-VAL283
ALEU234-TRP256
AVAL266-VAL283
ELEU234-TRP256
EVAL266-VAL283
PPHE65-ILE84
NPHE65-ILE84
HPHE65-ILE84
JPHE65-ILE84
DPHE65-ILE84
BPHE65-ILE84
FPHE65-ILE84
ILEU234-TRP256

site_idSWS_FT_FI3
Number of Residues176
DetailsTOPO_DOM: Mitochondrial intermembrane => ECO:0000305|PubMed:27099988, ECO:0000305|PubMed:27642048
ChainResidueDetails
LSER85-ASP107
PSER85-ASP107
NSER85-ASP107
HSER85-ASP107
JSER85-ASP107
DSER85-ASP107
BSER85-ASP107
FSER85-ASP107

site_idSWS_FT_FI4
Number of Residues536
DetailsTOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:23755363, ECO:0000305|PubMed:27099988
ChainResidueDetails
KMET284-ASP351
OMET284-ASP351
MMET284-ASP351
GMET284-ASP351
IMET284-ASP351
CMET284-ASP351
AMET284-ASP351
EMET284-ASP351

site_idSWS_FT_FI5
Number of Residues16
DetailsMOD_RES: Phosphoserine; by CaMK2 => ECO:0000305|PubMed:23051746
ChainResidueDetails
KSER57
ISER92
CSER57
CSER92
ASER57
ASER92
ESER57
ESER92
KSER92
OSER57
OSER92
MSER57
MSER92
GSER57
GSER92
ISER57

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q3UMR5
ChainResidueDetails
KLYS332
OLYS332
MLYS332
GLYS332
ILYS332
CLYS332
ALYS332
ELYS332

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PDB entries from 2024-07-24

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