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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6NZZ

LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001678biological_processintracellular glucose homeostasis
A0002329biological_processpre-B cell differentiation
A0005225molecular_functionvolume-sensitive anion channel activity
A0005253molecular_functionmonoatomic anion channel activity
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006820biological_processmonoatomic anion transport
A0006884biological_processcell volume homeostasis
A0006970biological_processresponse to osmotic stress
A0007283biological_processspermatogenesis
A0009986cellular_componentcell surface
A0015711biological_processorganic anion transport
A0015734biological_processtaurine transmembrane transport
A0015810biological_processaspartate transmembrane transport
A0016020cellular_componentmembrane
A0030154biological_processcell differentiation
A0032024biological_processpositive regulation of insulin secretion
A0034214biological_processprotein hexamerization
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0042802molecular_functionidentical protein binding
A0045663biological_processpositive regulation of myoblast differentiation
A0098656biological_processmonoatomic anion transmembrane transport
A0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
A1902476biological_processchloride transmembrane transport
B0001678biological_processintracellular glucose homeostasis
B0002329biological_processpre-B cell differentiation
B0005225molecular_functionvolume-sensitive anion channel activity
B0005253molecular_functionmonoatomic anion channel activity
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006820biological_processmonoatomic anion transport
B0006884biological_processcell volume homeostasis
B0006970biological_processresponse to osmotic stress
B0007283biological_processspermatogenesis
B0009986cellular_componentcell surface
B0015711biological_processorganic anion transport
B0015734biological_processtaurine transmembrane transport
B0015810biological_processaspartate transmembrane transport
B0016020cellular_componentmembrane
B0030154biological_processcell differentiation
B0032024biological_processpositive regulation of insulin secretion
B0034214biological_processprotein hexamerization
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0042802molecular_functionidentical protein binding
B0045663biological_processpositive regulation of myoblast differentiation
B0098656biological_processmonoatomic anion transmembrane transport
B0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
B0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
B1902476biological_processchloride transmembrane transport
C0001678biological_processintracellular glucose homeostasis
C0002329biological_processpre-B cell differentiation
C0005225molecular_functionvolume-sensitive anion channel activity
C0005253molecular_functionmonoatomic anion channel activity
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006820biological_processmonoatomic anion transport
C0006884biological_processcell volume homeostasis
C0006970biological_processresponse to osmotic stress
C0007283biological_processspermatogenesis
C0009986cellular_componentcell surface
C0015711biological_processorganic anion transport
C0015734biological_processtaurine transmembrane transport
C0015810biological_processaspartate transmembrane transport
C0016020cellular_componentmembrane
C0030154biological_processcell differentiation
C0032024biological_processpositive regulation of insulin secretion
C0034214biological_processprotein hexamerization
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0042802molecular_functionidentical protein binding
C0045663biological_processpositive regulation of myoblast differentiation
C0098656biological_processmonoatomic anion transmembrane transport
C0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
C0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
C1902476biological_processchloride transmembrane transport
D0001678biological_processintracellular glucose homeostasis
D0002329biological_processpre-B cell differentiation
D0005225molecular_functionvolume-sensitive anion channel activity
D0005253molecular_functionmonoatomic anion channel activity
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006820biological_processmonoatomic anion transport
D0006884biological_processcell volume homeostasis
D0006970biological_processresponse to osmotic stress
D0007283biological_processspermatogenesis
D0009986cellular_componentcell surface
D0015711biological_processorganic anion transport
D0015734biological_processtaurine transmembrane transport
D0015810biological_processaspartate transmembrane transport
D0016020cellular_componentmembrane
D0030154biological_processcell differentiation
D0032024biological_processpositive regulation of insulin secretion
D0034214biological_processprotein hexamerization
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0042802molecular_functionidentical protein binding
D0045663biological_processpositive regulation of myoblast differentiation
D0098656biological_processmonoatomic anion transmembrane transport
D0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
D0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
D1902476biological_processchloride transmembrane transport
E0001678biological_processintracellular glucose homeostasis
E0002329biological_processpre-B cell differentiation
E0005225molecular_functionvolume-sensitive anion channel activity
E0005253molecular_functionmonoatomic anion channel activity
E0005737cellular_componentcytoplasm
E0005765cellular_componentlysosomal membrane
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006820biological_processmonoatomic anion transport
E0006884biological_processcell volume homeostasis
E0006970biological_processresponse to osmotic stress
E0007283biological_processspermatogenesis
E0009986cellular_componentcell surface
E0015711biological_processorganic anion transport
E0015734biological_processtaurine transmembrane transport
E0015810biological_processaspartate transmembrane transport
E0016020cellular_componentmembrane
E0030154biological_processcell differentiation
E0032024biological_processpositive regulation of insulin secretion
E0034214biological_processprotein hexamerization
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0042802molecular_functionidentical protein binding
E0045663biological_processpositive regulation of myoblast differentiation
E0098656biological_processmonoatomic anion transmembrane transport
E0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
E0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
E1902476biological_processchloride transmembrane transport
F0001678biological_processintracellular glucose homeostasis
F0002329biological_processpre-B cell differentiation
F0005225molecular_functionvolume-sensitive anion channel activity
F0005253molecular_functionmonoatomic anion channel activity
F0005737cellular_componentcytoplasm
F0005765cellular_componentlysosomal membrane
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006820biological_processmonoatomic anion transport
F0006884biological_processcell volume homeostasis
F0006970biological_processresponse to osmotic stress
F0007283biological_processspermatogenesis
F0009986cellular_componentcell surface
F0015711biological_processorganic anion transport
F0015734biological_processtaurine transmembrane transport
F0015810biological_processaspartate transmembrane transport
F0016020cellular_componentmembrane
F0030154biological_processcell differentiation
F0032024biological_processpositive regulation of insulin secretion
F0034214biological_processprotein hexamerization
F0034220biological_processmonoatomic ion transmembrane transport
F0034702cellular_componentmonoatomic ion channel complex
F0042802molecular_functionidentical protein binding
F0045663biological_processpositive regulation of myoblast differentiation
F0098656biological_processmonoatomic anion transmembrane transport
F0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
F0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
F1902476biological_processchloride transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue POV A 902
ChainResidue
ATRP120
AHIS132
site_idAC2
Number of Residues2
Detailsbinding site for residue POV A 903
ChainResidue
AILE320
ASER323
site_idAC3
Number of Residues2
Detailsbinding site for residue POV B 902
ChainResidue
BTRP120
BHIS132
site_idAC4
Number of Residues2
Detailsbinding site for residue POV B 903
ChainResidue
BILE320
BSER323
site_idAC5
Number of Residues1
Detailsbinding site for residue POV C 901
ChainResidue
DILE320
site_idAC6
Number of Residues2
Detailsbinding site for residue POV C 902
ChainResidue
CTRP120
CHIS132
site_idAC7
Number of Residues2
Detailsbinding site for residue POV C 903
ChainResidue
CILE320
CSER323
site_idAC8
Number of Residues1
Detailsbinding site for residue POV D 901
ChainResidue
EILE320
site_idAC9
Number of Residues2
Detailsbinding site for residue POV D 902
ChainResidue
DTRP120
DHIS132
site_idAD1
Number of Residues2
Detailsbinding site for residue POV D 903
ChainResidue
DILE320
DSER323
site_idAD2
Number of Residues2
Detailsbinding site for residue POV E 902
ChainResidue
ETRP120
EHIS132
site_idAD3
Number of Residues2
Detailsbinding site for residue POV E 903
ChainResidue
EILE320
ESER323
site_idAD4
Number of Residues1
Detailsbinding site for residue POV F 901
ChainResidue
AILE320
site_idAD5
Number of Residues2
Detailsbinding site for residue POV F 902
ChainResidue
FTRP120
FHIS132
site_idAD6
Number of Residues2
Detailsbinding site for residue POV F 903
ChainResidue
FILE320
FSER323
site_idAD7
Number of Residues2
Detailsbinding site for residue L9Y F 904
ChainResidue
AARG103
FARG103
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues144
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues108
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues126
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues174
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues144
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsSite: {"description":"Required for anion selectivity","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000303"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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