6NX1
STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC CO-ACTIVATOR PEPTIDE AND COMPOUND-3 AKA 1,1,1,3,3,3-HEXAFLUORO-2-{4-[1-(4- LUOROBENZENESULFONYL)CYCLOPENTYL]PHENYL}PROPAN-2-OL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue L7D A 501 |
| Chain | Residue |
| A | LEU209 |
| A | TYR306 |
| A | HIS407 |
| A | LEU411 |
| A | PHE420 |
| A | LEU240 |
| A | MET243 |
| A | MET246 |
| A | SER247 |
| A | CYS284 |
| A | GLN285 |
| A | PHE288 |
| A | TRP299 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue L7D B 501 |
| Chain | Residue |
| B | LEU240 |
| B | MET243 |
| B | SER247 |
| B | GLN285 |
| B | PHE288 |
| B | TRP299 |
| B | LEU324 |
| B | HIS407 |
| B | LEU411 |
| B | PHE420 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12578355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M13","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"26534988","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 4"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
