Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 701 |
| Chain | Residue |
| A | ARG222 |
| A | GLU248 |
| A | HOH1014 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 702 |
| Chain | Residue |
| A | SER272 |
| A | THR274 |
| A | HOH1153 |
| A | HOH1287 |
| A | HOH1290 |
| A | HOH1325 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 703 |
| Chain | Residue |
| A | SER540 |
| A | HOH823 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 704 |
| Chain | Residue |
| A | ASN24 |
| A | HOH844 |
| A | HOH846 |
| B | ASN24 |
| B | HOH967 |
| C | ASN24 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CO3 A 705 |
| Chain | Residue |
| A | TYR96 |
| A | ARG124 |
| A | SER152 |
| A | HOH1253 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CO3 A 706 |
| Chain | Residue |
| A | LYS560 |
| A | VAL561 |
| A | GLY578 |
| A | PGE729 |
| A | HOH1072 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 707 |
| Chain | Residue |
| A | ASP426 |
| A | SER449 |
| A | ARG452 |
| A | GLY527 |
| A | HOH892 |
| A | HOH1116 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 708 |
| Chain | Residue |
| A | TYR480 |
| A | SER537 |
| A | TYR562 |
| A | HOH822 |
| A | HOH868 |
| A | HOH935 |
| A | HOH960 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 709 |
| Chain | Residue |
| A | GLN314 |
| A | ASN315 |
| A | TYR335 |
| A | EDO726 |
| A | GOL731 |
| A | HOH1209 |
| B | PHE370 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 710 |
| Chain | Residue |
| A | LYS252 |
| A | HOH1100 |
| B | ILE298 |
| B | PHE322 |
| B | GOL711 |
| B | HOH953 |
| B | HOH970 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 711 |
| Chain | Residue |
| A | THR522 |
| A | TYR524 |
| A | ASP554 |
| A | ALA556 |
| A | HOH857 |
| A | HOH938 |
| A | HOH964 |
| C | GLN489 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 712 |
| Chain | Residue |
| A | LYS405 |
| A | PHE413 |
| A | ALA414 |
| A | GOL713 |
| A | HOH837 |
| A | HOH1036 |
| A | HOH1135 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 713 |
| Chain | Residue |
| A | LYS405 |
| A | LYS462 |
| A | GLY463 |
| A | ASP486 |
| A | GOL712 |
| A | HOH860 |
| A | HOH1036 |
| A | HOH1055 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 714 |
| Chain | Residue |
| A | HIS457 |
| A | TYR460 |
| A | GLU485 |
| A | LEU508 |
| A | HOH965 |
| A | HOH1061 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 715 |
| Chain | Residue |
| A | GLU263 |
| A | LYS265 |
| A | SER300 |
| A | ASP302 |
| C | GOL709 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 716 |
| Chain | Residue |
| A | ASP383 |
| A | PO4730 |
| A | HOH870 |
| A | HOH904 |
| B | VAL424 |
| B | GOL710 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 717 |
| Chain | Residue |
| A | CYS510 |
| A | LYS511 |
| A | ASN542 |
| A | THR544 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 718 |
| Chain | Residue |
| A | ALA243 |
| A | ARG245 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 719 |
| Chain | Residue |
| A | EDO721 |
| A | HOH806 |
| A | HOH1256 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 720 |
| Chain | Residue |
| A | PRO410 |
| A | LEU412 |
| A | HOH827 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 721 |
| Chain | Residue |
| A | ASN331 |
| A | EDO719 |
| A | HOH807 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 722 |
| Chain | Residue |
| A | ASP186 |
| A | GLY187 |
| A | ALA188 |
| A | HOH948 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 723 |
| Chain | Residue |
| A | TYR476 |
| A | TYR529 |
| A | HOH1238 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 724 |
| Chain | Residue |
| A | LYS176 |
| B | SER167 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 725 |
| Chain | Residue |
| A | ARG235 |
| A | HOH1231 |
| B | ILE185 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 726 |
| Chain | Residue |
| A | SER285 |
| A | GLN314 |
| A | GOL709 |
| A | HOH1209 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 727 |
| Chain | Residue |
| A | GLY578 |
| A | VAL579 |
| A | HOH812 |
| A | HOH1112 |
| C | LYS572 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue PEG A 728 |
| Chain | Residue |
| A | SER102 |
| A | PHE103 |
| A | ASN104 |
| A | VAL117 |
| A | HIS118 |
| A | ASP119 |
| A | ASP120 |
| A | HOH1005 |
| C | SER92 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue PGE A 729 |
| Chain | Residue |
| A | SER541 |
| A | VAL561 |
| A | TYR562 |
| A | LEU563 |
| A | CO3706 |
| A | HOH817 |
| A | HOH1124 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 730 |
| Chain | Residue |
| A | ILE360 |
| A | GOL716 |
| A | HOH850 |
| A | HOH870 |
| site_id | AF4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 731 |
| Chain | Residue |
| A | ASN315 |
| A | ASN337 |
| A | GOL709 |
| A | HOH814 |
| A | HOH826 |
| A | HOH998 |
| B | GLU342 |
| B | LEU368 |
| B | PHE370 |
| site_id | AF5 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 732 |
| Chain | Residue |
| A | ARG233 |
| A | ARG295 |
| A | HOH801 |
| A | HOH802 |
| A | HOH803 |
| B | ARG233 |
| B | ARG295 |
| C | ARG233 |
| C | ARG295 |
| site_id | AF6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 733 |
| Chain | Residue |
| A | GLU342 |
| A | TRP344 |
| A | PHE370 |
| C | GLN314 |
| C | ASN315 |
| C | TYR335 |
| C | EDO715 |
| C | EDO728 |
| C | HOH869 |
| C | HOH951 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 734 |
| Chain | Residue |
| A | ASP581 |
| A | ILE583 |
| A | HOH906 |
| A | HOH921 |
| C | GLN600 |
| C | EDO725 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 735 |
| Chain | Residue |
| A | ARG340 |
| A | GLU342 |
| A | LEU368 |
| A | HOH816 |
| A | HOH1272 |
| C | ASN315 |
| C | ASN337 |
| site_id | AF9 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 B 701 |
| Chain | Residue |
| B | SER587 |
| B | THR588 |
| B | ALA589 |
| B | THR605 |
| B | HOH930 |
| B | HOH1066 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 702 |
| Chain | Residue |
| B | ARG222 |
| B | GLU248 |
| B | HOH1034 |
| B | HOH1304 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 703 |
| Chain | Residue |
| B | PHE200 |
| B | VAL201 |
| B | LYS231 |
| B | ARG233 |
| B | HOH969 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 704 |
| Chain | Residue |
| B | SER272 |
| B | THR274 |
| B | HOH1111 |
| B | HOH1232 |
| B | HOH1262 |
| B | HOH1274 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 705 |
| Chain | Residue |
| B | SER285 |
| B | GLN358 |
| B | HOH1138 |
| site_id | AG5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 706 |
| Chain | Residue |
| A | PRO410 |
| B | TYR476 |
| B | GLY528 |
| B | TYR529 |
| B | HOH819 |
| B | HOH1089 |
| B | HOH1096 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 707 |
| Chain | Residue |
| B | GLN314 |
| B | ASN315 |
| B | HOH973 |
| B | HOH995 |
| C | PHE370 |
| C | HOH810 |
| site_id | AG7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 708 |
| Chain | Residue |
| B | LYS252 |
| B | GLN290 |
| B | HOH859 |
| B | HOH1151 |
| C | PHE322 |
| C | GOL707 |
| C | HOH889 |
| C | HOH893 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 709 |
| Chain | Residue |
| B | ASP377 |
| B | TYR396 |
| B | HOH879 |
| B | HOH884 |
| site_id | AG9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 710 |
| Chain | Residue |
| A | GOL716 |
| B | ASP426 |
| B | SER449 |
| B | ARG452 |
| B | TYR476 |
| B | GLY527 |
| B | HOH867 |
| B | HOH1018 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 711 |
| Chain | Residue |
| A | GOL710 |
| B | GLU263 |
| B | LYS265 |
| B | SER300 |
| B | TYR324 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 712 |
| Chain | Residue |
| B | HIS457 |
| B | HOH825 |
| B | HOH902 |
| B | HOH934 |
| B | HOH1055 |
| site_id | AH3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 713 |
| Chain | Residue |
| B | VAL561 |
| B | TYR562 |
| B | LEU563 |
| B | THR565 |
| B | EDO724 |
| B | HOH990 |
| B | HOH1031 |
| B | HOH1169 |
| site_id | AH4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 714 |
| Chain | Residue |
| B | TYR599 |
| B | GLN600 |
| B | HOH814 |
| B | HOH1203 |
| C | ASP581 |
| C | ILE583 |
| site_id | AH5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 715 |
| Chain | Residue |
| A | HOH913 |
| B | LYS122 |
| B | HOH845 |
| site_id | AH6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 716 |
| Chain | Residue |
| B | ALA243 |
| B | ARG245 |
| B | HOH842 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 717 |
| Chain | Residue |
| B | TYR396 |
| B | ARG399 |
| B | ARG401 |
| B | ASP434 |
| B | EDO723 |
| site_id | AH8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 718 |
| Chain | Residue |
| A | GLN489 |
| B | THR522 |
| B | TYR524 |
| B | ASP554 |
| B | HOH869 |
| B | HOH887 |
| site_id | AH9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 719 |
| Chain | Residue |
| B | THR52 |
| B | TYR56 |
| B | GLU73 |
| B | ASN110 |
| B | VAL111 |
| B | HOH809 |
| B | HOH1065 |
| site_id | AI1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 720 |
| Chain | Residue |
| B | ARG235 |
| C | TYR179 |
| C | ILE185 |
| site_id | AI2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 721 |
| Chain | Residue |
| B | PRO410 |
| B | HOH826 |
| B | HOH838 |
| C | TYR524 |
| C | EDO729 |
| C | HOH883 |
| site_id | AI3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 722 |
| Chain | Residue |
| B | HOH806 |
| B | HOH1084 |
| site_id | AI4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 723 |
| Chain | Residue |
| B | GLY430 |
| B | HIS431 |
| B | SER456 |
| B | EDO717 |
| site_id | AI5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 724 |
| Chain | Residue |
| B | THR558 |
| B | THR559 |
| B | LYS560 |
| B | VAL561 |
| B | GOL713 |
| site_id | AI6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 725 |
| Chain | Residue |
| B | GLU436 |
| B | GLY437 |
| B | LYS462 |
| B | HOH801 |
| B | HOH982 |
| B | HOH1062 |
| site_id | AI7 |
| Number of Residues | 1 |
| Details | binding site for residue PEG B 726 |
| site_id | AI8 |
| Number of Residues | 1 |
| Details | binding site for residue PEG B 727 |
| site_id | AI9 |
| Number of Residues | 9 |
| Details | binding site for residue PEG B 728 |
| Chain | Residue |
| B | ASN315 |
| B | LEU316 |
| B | ASP317 |
| B | TYR335 |
| B | ASN337 |
| B | HOH1060 |
| C | CYS341 |
| C | LEU368 |
| C | PHE370 |
| site_id | AJ1 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 729 |
| Chain | Residue |
| B | SER598 |
| B | SER614 |
| B | HOH1282 |
| C | ARG585 |
| site_id | AJ2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 730 |
| Chain | Residue |
| B | ARG230 |
| B | LYS231 |
| B | HOH966 |
| B | HOH1109 |
| C | ASN258 |
| site_id | AJ3 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 701 |
| Chain | Residue |
| A | ARG585 |
| C | SER598 |
| C | SER614 |
| C | HOH1237 |
| site_id | AJ4 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 702 |
| Chain | Residue |
| C | ARG222 |
| C | GLU248 |
| C | HOH911 |
| site_id | AJ5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 703 |
| Chain | Residue |
| C | ARG245 |
| C | SER272 |
| C | THR274 |
| C | ASN306 |
| C | HOH904 |
| C | HOH929 |
| site_id | AJ6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 704 |
| Chain | Residue |
| C | GLU436 |
| C | GLY437 |
| C | LYS462 |
| C | GLY463 |
| C | ASP486 |
| C | HOH803 |
| site_id | AJ7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 705 |
| Chain | Residue |
| A | ALA284 |
| A | SER285 |
| A | ASN355 |
| A | ILE357 |
| A | GLN358 |
| C | ASP270 |
| C | SER272 |
| C | HOH809 |
| site_id | AJ8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 706 |
| Chain | Residue |
| C | ALA509 |
| C | ASN542 |
| C | THR544 |
| C | HOH843 |
| site_id | AJ9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 707 |
| Chain | Residue |
| B | GOL708 |
| C | GLU263 |
| C | LYS265 |
| C | SER300 |
| C | TYR324 |
| C | HOH1043 |
| site_id | AK1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 708 |
| Chain | Residue |
| C | ASP377 |
| C | TYR396 |
| C | ARG399 |
| C | HOH990 |
| C | HOH1114 |
| site_id | AK2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 709 |
| Chain | Residue |
| A | ILE298 |
| A | PHE322 |
| A | GOL715 |
| A | HOH953 |
| C | LYS252 |
| C | GLN290 |
| C | HOH855 |
| C | HOH966 |
| site_id | AK3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 710 |
| Chain | Residue |
| C | VAL561 |
| C | TYR562 |
| C | LEU563 |
| C | THR565 |
| C | GOL712 |
| site_id | AK4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 711 |
| Chain | Residue |
| C | ASP426 |
| C | SER449 |
| C | ARG452 |
| C | TYR476 |
| C | GLY527 |
| C | HOH903 |
| site_id | AK5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 712 |
| Chain | Residue |
| C | THR558 |
| C | THR559 |
| C | LYS560 |
| C | VAL561 |
| C | GLY578 |
| C | GOL710 |
| site_id | AK6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 713 |
| Chain | Residue |
| A | TYR529 |
| C | PRO410 |
| C | ASP411 |
| C | HOH857 |
| C | HOH959 |
| C | HOH1118 |
| site_id | AK7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 714 |
| Chain | Residue |
| A | HOH1027 |
| C | HOH829 |
| site_id | AK8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 715 |
| Chain | Residue |
| A | GOL733 |
| C | SER285 |
| C | GLN314 |
| C | HOH869 |
| site_id | AK9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 716 |
| Chain | Residue |
| C | TYR480 |
| C | EDO719 |
| C | HOH816 |
| C | HOH876 |
| site_id | AL1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 717 |
| Chain | Residue |
| C | ASP216 |
| C | THR244 |
| site_id | AL2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 718 |
| Chain | Residue |
| C | TYR396 |
| C | ARG399 |
| C | ARG401 |
| C | ASP434 |
| C | HOH915 |
| site_id | AL3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 719 |
| Chain | Residue |
| C | TYR480 |
| C | SER537 |
| C | EDO716 |
| C | HOH861 |
| site_id | AL4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 720 |
| Chain | Residue |
| C | HIS334 |
| C | GLU362 |
| C | EDO728 |
| C | HOH925 |
| site_id | AL5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 721 |
| Chain | Residue |
| C | ARG351 |
| C | TRP379 |
| C | EDO722 |
| C | HOH815 |
| C | HOH990 |
| site_id | AL6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 722 |
| Chain | Residue |
| C | EDO721 |
| C | PEG730 |
| C | HOH1100 |
| C | HOH1192 |
| site_id | AL7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 723 |
| Chain | Residue |
| B | HOH1321 |
| C | TYR324 |
| site_id | AL8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 724 |
| Chain | Residue |
| B | GLN489 |
| C | THR522 |
| C | TYR524 |
| C | ASP554 |
| C | HOH838 |
| C | HOH841 |
| C | HOH883 |
| site_id | AL9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 725 |
| Chain | Residue |
| A | GOL734 |
| C | LYS572 |
| C | THR582 |
| site_id | AM1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 726 |
| Chain | Residue |
| C | PEG730 |
| C | HOH906 |
| site_id | AM2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 727 |
| Chain | Residue |
| C | TRP125 |
| C | SER128 |
| site_id | AM3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 728 |
| Chain | Residue |
| A | GOL733 |
| C | TYR335 |
| C | GLU362 |
| C | EDO720 |
| C | HOH951 |
| site_id | AM4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 729 |
| Chain | Residue |
| B | EDO721 |
| C | TYR524 |
| C | HOH1122 |
| C | HOH1187 |
| site_id | AM5 |
| Number of Residues | 5 |
| Details | binding site for residue PEG C 730 |
| Chain | Residue |
| C | ARG311 |
| C | ASN331 |
| C | EDO722 |
| C | EDO726 |
| C | HOH1068 |
