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6NW7

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with S-Adenosyl-L-homocysteine

Functional Information from GO Data
ChainGOidnamespacecontents
A0002939biological_processtRNA N1-guanine methylation
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006400biological_processtRNA modification
A0008033biological_processtRNA processing
A0008168molecular_functionmethyltransferase activity
A0016740molecular_functiontransferase activity
A0032259biological_processmethylation
A0052906molecular_functiontRNA (guanine(37)-N1)-methyltransferase activity
B0002939biological_processtRNA N1-guanine methylation
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006400biological_processtRNA modification
B0008033biological_processtRNA processing
B0008168molecular_functionmethyltransferase activity
B0016740molecular_functiontransferase activity
B0032259biological_processmethylation
B0052906molecular_functiontRNA (guanine(37)-N1)-methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue SAH A 301
ChainResidue
APRO83
AGLY134
ATYR136
ALEU138
AGLY140
AGLY141
AHOH422
AHOH431
BGLU180
BHOH484
ATHR84
APRO85
AGLY109
ATYR111
AGLU112
AGLY113
ASER132
AILE133

site_idAC2
Number of Residues8
Detailsbinding site for residue SO4 A 302
ChainResidue
AALA123
AARG125
AMET126
AARG127
AARG186
AHOH411
BSER51
BTYR53

site_idAC3
Number of Residues16
Detailsbinding site for residue SAH B 301
ChainResidue
AGLU180
BPRO83
BTHR84
BPRO85
BGLY109
BTYR111
BGLU112
BGLY113
BSER132
BILE133
BGLY134
BTYR136
BLEU138
BASN139
BGLY140
BGLY141

Functional Information from PROSITE/UniProt
site_idPS00430
Number of Residues86
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. gsmkidvvtifpeylqpvrqslpgkaidaglvdvavhdlrrwthdvhksvddspygggpgmvmkptvwgdaldeicts.....................................ETLLVVPT
ChainResidueDetails
AGLY-1-THR84

246031

PDB entries from 2025-12-10

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