Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NW5

Crystal structure of TmPep1050 aminopeptidase with its metal cofactors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008810	molecular_function	cellulase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0046872	molecular_function	metal ion binding
B	0004177	molecular_function	aminopeptidase activity
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008810	molecular_function	cellulase activity
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0046872	molecular_function	metal ion binding
C	0004177	molecular_function	aminopeptidase activity
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008810	molecular_function	cellulase activity
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0046872	molecular_function	metal ion binding
D	0004177	molecular_function	aminopeptidase activity
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008810	molecular_function	cellulase activity
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS60
A	ASP168
A	ASP220
A	HOH771

site_id	AC2
Number of Residues	5
Details	binding site for residue CO A 402

Chain	Residue
A	ASP168
A	GLU198
A	HIS307
A	HOH655
A	HOH771

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 403

Chain	Residue
A	LYS2
A	ARG6
A	VAL156
A	GLU157
A	HOH527
A	HOH658

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 A 404

Chain	Residue
A	SER254
A	LYS255
A	ARG256
A	HOH504
A	HOH509
A	HOH564
A	HOH589

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 405

Chain	Residue
A	ASP72
A	ASP73
A	ARG136
A	HOH510

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 406

Chain	Residue
A	ARG327
A	HOH519

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 A 407

Chain	Residue
A	LYS271
A	TYR272

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 A 408

Chain	Residue
A	MET1
A	LYS2
A	GLU3
A	LEU4
A	HOH677

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN B 401

Chain	Residue
B	HIS60
B	ASP168
B	ASP220
B	HOH789

site_id	AD1
Number of Residues	5
Details	binding site for residue CO B 402

Chain	Residue
B	ASP168
B	GLU198
B	HIS307
B	HOH691
B	HOH789

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 B 403

Chain	Residue
B	SER254
B	LYS255
B	ARG256
B	HOH519
B	HOH599
C	HOH620

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 B 404

Chain	Residue
B	LYS2
B	ARG6
B	VAL156
B	GLU157
B	HOH566

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 B 405

Chain	Residue
B	LYS48
B	ILE183
B	HOH755

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 B 406

Chain	Residue
B	HOH507
B	HOH521
B	HOH546
D	ARG182
D	ILE326
D	ARG327

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 B 407

Chain	Residue
B	ASP72
B	ASP73
B	ARG136
B	HOH505

site_id	AD7
Number of Residues	1
Details	binding site for residue SO4 B 408

Chain	Residue
B	ARG327

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 B 409

Chain	Residue
B	LYS53
B	ARG256
B	ASN260

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 B 410

Chain	Residue
B	MET1
B	LYS2
B	GLU3
B	LEU4
B	HOH529

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN C 401

Chain	Residue
C	HIS60
C	ASP168
C	ASP220
C	HOH751

site_id	AE2
Number of Residues	4
Details	binding site for residue CO C 402

Chain	Residue
C	ASP168
C	GLU198
C	HIS307
C	HOH751

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 C 403

Chain	Residue
C	LYS2
C	ARG6
C	VAL156
C	GLU157
C	HOH505

site_id	AE4
Number of Residues	3
Details	binding site for residue SO4 C 404

Chain	Residue
C	LYS271
C	TYR272
C	HOH592

site_id	AE5
Number of Residues	7
Details	binding site for residue SO4 C 405

Chain	Residue
D	HOH520
C	SER254
C	LYS255
C	ARG256
C	HOH506
C	HOH540
C	HOH644

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 C 406

Chain	Residue
C	ASP72
C	ASP73
C	ARG136
C	HOH711

site_id	AE7
Number of Residues	5
Details	binding site for residue SO4 C 407

Chain	Residue
C	MET1
C	LYS2
C	GLU3
C	LEU4
C	HOH550

site_id	AE8
Number of Residues	4
Details	binding site for residue ZN D 401

Chain	Residue
D	HIS60
D	ASP168
D	ASP220
D	OH409

site_id	AE9
Number of Residues	5
Details	binding site for residue CO D 402

Chain	Residue
D	ASP168
D	GLU198
D	HIS307
D	OH409
D	HOH568

site_id	AF1
Number of Residues	5
Details	binding site for residue SO4 D 403

Chain	Residue
D	LYS2
D	ARG6
D	VAL156
D	GLU157
D	HOH562

site_id	AF2
Number of Residues	5
Details	binding site for residue SO4 D 404

Chain	Residue
D	ASP72
D	ASP73
D	ARG136
D	HOH695
D	HOH754

site_id	AF3
Number of Residues	3
Details	binding site for residue SO4 D 405

Chain	Residue
D	LYS271
D	TYR272
D	HOH574

site_id	AF4
Number of Residues	7
Details	binding site for residue SO4 D 406

Chain	Residue
B	HOH509
D	SER254
D	LYS255
D	ARG256
D	HOH503
D	HOH517
D	HOH561

site_id	AF5
Number of Residues	3
Details	binding site for residue SO4 D 407

Chain	Residue
D	LEU201
D	MET285
D	HOH596

site_id	AF6
Number of Residues	6
Details	binding site for residue SO4 D 408

Chain	Residue
D	MET1
D	LYS2
D	GLU3
D	LEU4
D	HOH501
D	HOH710

site_id	AF7
Number of Residues	10
Details	binding site for residue OH D 409

Chain	Residue
D	HIS60
D	ASP168
D	GLU197
D	GLU198
D	ASP220
D	ZN401
D	CO402
D	HOH568
D	HOH576
D	HOH650

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)