Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NVT

Crystal structure of TLA-1 extended spectrum Beta-lactamase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030655	biological_process	beta-lactam antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030655	biological_process	beta-lactam antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0030655	biological_process	beta-lactam antibiotic catabolic process
D	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER70
A	SER130
A	THR235
A	GLY236
A	SER237
A	HOH409
A	HOH416
A	HOH458

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	TRP105
A	ASN132
A	HIS170
A	THR104

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 303

Chain	Residue
A	LYS124
A	ARG129
A	HOH437
A	HOH522
A	HOH557

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 304

Chain	Residue
A	LYS93
A	HOH406
A	HOH508

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS98
A	LYS99
A	SER100
A	HOH412
A	HOH426
A	HOH470

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 306

Chain	Residue
A	ARG129
A	THR215

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 307

Chain	Residue
A	PRO226
A	ASP227
A	HOH405

site_id	AC8
Number of Residues	4
Details	binding site for residue CL A 308

Chain	Residue
A	PHE193
A	ASN196
A	ILE198
A	LEU199

site_id	AC9
Number of Residues	5
Details	binding site for residue ACT A 309

Chain	Residue
A	ASN61
A	GLU62
A	LYS63
A	HIS64
A	ACT317

site_id	AD1
Number of Residues	5
Details	binding site for residue ACT A 310

Chain	Residue
A	HOH417
A	HOH463
A	HOH521
A	HOH630
D	SER100

site_id	AD2
Number of Residues	1
Details	binding site for residue ACT A 311

Chain	Residue
A	LYS201

site_id	AD3
Number of Residues	5
Details	binding site for residue ACT A 312

Chain	Residue
A	LYS270
A	SER271
A	HOH401
D	LYS93
D	HOH522

site_id	AD4
Number of Residues	5
Details	binding site for residue ACT A 313

Chain	Residue
A	SER118
A	SER120
A	GLU121
A	HOH415
A	HOH633

site_id	AD5
Number of Residues	4
Details	binding site for residue ACT A 314

Chain	Residue
A	GLY217
A	HOH558
A	HOH559
A	HOH609

site_id	AD6
Number of Residues	2
Details	binding site for residue ACT A 315

Chain	Residue
A	LYS195
A	HOH534

site_id	AD7
Number of Residues	3
Details	binding site for residue ACT A 316

Chain	Residue
A	SER90
A	ILE91
A	ASN202

site_id	AD8
Number of Residues	5
Details	binding site for residue ACT A 317

Chain	Residue
A	LYS30
A	GLU34
A	ASN61
A	GLU62
A	ACT309

site_id	AD9
Number of Residues	6
Details	binding site for residue ACT A 318

Chain	Residue
A	GLY144
A	THR145
A	THR165
A	HOH402
A	HOH419
A	HOH591

site_id	AE1
Number of Residues	4
Details	binding site for residue ACT A 319

Chain	Residue
A	LYS270
A	ASP272
A	HOH519
D	ASN88

site_id	AE2
Number of Residues	3
Details	binding site for residue ACT A 320

Chain	Residue
A	TRP180
A	HOH404
A	HOH617

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 B 301

Chain	Residue
B	ARG129
B	HOH415
B	HOH448
B	HOH550

site_id	AE4
Number of Residues	3
Details	binding site for residue SO4 B 302

Chain	Residue
B	PRO226
B	ASP227
B	HOH412

site_id	AE5
Number of Residues	3
Details	binding site for residue SO4 B 303

Chain	Residue
B	LYS201
B	HOH446
B	HOH530

site_id	AE6
Number of Residues	3
Details	binding site for residue SO4 B 304

Chain	Residue
B	SER90
B	ILE91
B	HOH445

site_id	AE7
Number of Residues	5
Details	binding site for residue SO4 B 305

Chain	Residue
B	HIS170
B	HOH425
B	THR104
B	TRP105
B	ASN132

site_id	AE8
Number of Residues	7
Details	binding site for residue SO4 B 306

Chain	Residue
B	SER70
B	SER130
B	THR235
B	GLY236
B	SER237
B	HOH403
B	HOH557

site_id	AE9
Number of Residues	4
Details	binding site for residue SO4 B 307

Chain	Residue
B	ARG129
B	THR215
B	HOH421
B	HOH512

site_id	AF1
Number of Residues	4
Details	binding site for residue CL B 308

Chain	Residue
B	PHE193
B	ASN196
B	ILE198
B	LEU199

site_id	AF2
Number of Residues	2
Details	binding site for residue ACT B 309

Chain	Residue
B	LYS98
B	HOH411

site_id	AF3
Number of Residues	4
Details	binding site for residue ACT B 310

Chain	Residue
B	LYS30
B	GLU34
B	ASN61
B	HOH431

site_id	AF4
Number of Residues	4
Details	binding site for residue ACT B 311

Chain	Residue
B	LYS270
B	ASP272
B	HOH401
B	HOH438

site_id	AF5
Number of Residues	3
Details	binding site for residue ACT B 312

Chain	Residue
B	LYS93
B	LYS94
B	HOH408

site_id	AF6
Number of Residues	3
Details	binding site for residue ACT B 313

Chain	Residue
B	GLY217
B	HOH407
B	HOH646

site_id	AF7
Number of Residues	2
Details	binding site for residue ACT B 314

Chain	Residue
B	ASP92
B	SER118

site_id	AF8
Number of Residues	7
Details	binding site for residue SO4 C 301

Chain	Residue
C	SER70
C	SER130
C	THR235
C	GLY236
C	SER237
C	HOH407
C	HOH565

site_id	AF9
Number of Residues	5
Details	binding site for residue SO4 C 302

Chain	Residue
C	THR104
C	TRP105
C	ASN132
C	HIS170
C	HOH555

site_id	AG1
Number of Residues	1
Details	binding site for residue SO4 C 303

Chain	Residue
C	HOH479

site_id	AG2
Number of Residues	2
Details	binding site for residue SO4 C 304

Chain	Residue
C	ARG129
C	HOH428

site_id	AG3
Number of Residues	3
Details	binding site for residue SO4 C 305

Chain	Residue
C	ASP227
C	HOH411
C	HOH419

site_id	AG4
Number of Residues	6
Details	binding site for residue SO4 C 306

Chain	Residue
C	SER200
C	LYS201
C	HOH418
C	HOH426
C	HOH478
C	HOH504

site_id	AG5
Number of Residues	2
Details	binding site for residue SO4 C 307

Chain	Residue
C	SER90
C	ILE91

site_id	AG6
Number of Residues	6
Details	binding site for residue SO4 C 308

Chain	Residue
C	LYS99
C	SER100
C	HOH406
C	HOH455
C	HOH496
C	HOH503

site_id	AG7
Number of Residues	3
Details	binding site for residue SO4 C 309

Chain	Residue
C	ARG129
C	THR215
C	HOH430

site_id	AG8
Number of Residues	3
Details	binding site for residue SO4 C 310

Chain	Residue
C	LYS270
C	SER271
C	HOH402

site_id	AG9
Number of Residues	5
Details	binding site for residue CL C 311

Chain	Residue
C	THR214
C	THR216
C	LYS222
C	HIS233
C	HOH470

site_id	AH1
Number of Residues	5
Details	binding site for residue CL C 312

Chain	Residue
C	PRO67
C	ALA243
C	ASN245
C	TYR263
C	SER265

site_id	AH2
Number of Residues	4
Details	binding site for residue CL C 313

Chain	Residue
C	PHE193
C	ASN196
C	ILE198
C	LEU199

site_id	AH3
Number of Residues	4
Details	binding site for residue CL C 314

Chain	Residue
C	GLY144
C	THR145
C	HOH524
C	HOH633

site_id	AH4
Number of Residues	4
Details	binding site for residue ACT C 315

Chain	Residue
C	ASN114
C	HOH403
C	HOH511
D	LYS171

site_id	AH5
Number of Residues	4
Details	binding site for residue ACT C 316

Chain	Residue
C	LYS93
C	LYS94
C	HOH487
D	HOH410

site_id	AH6
Number of Residues	5
Details	binding site for residue ACT C 317

Chain	Residue
C	LYS30
C	GLU34
C	ASN61
C	GLU62
C	HOH499

site_id	AH7
Number of Residues	2
Details	binding site for residue ACT C 318

Chain	Residue
C	GLY217
C	HOH401

site_id	AH8
Number of Residues	4
Details	binding site for residue ACT C 319

Chain	Residue
C	LYS219
C	LYS276
C	ACT320
C	HOH431

site_id	AH9
Number of Residues	2
Details	binding site for residue ACT C 320

Chain	Residue
C	LYS276
C	ACT319

site_id	AI1
Number of Residues	2
Details	binding site for residue ACT C 321

Chain	Residue
C	ASP227
C	GLY228

site_id	AI2
Number of Residues	7
Details	binding site for residue SO4 D 301

Chain	Residue
D	SER70
D	SER130
D	THR235
D	GLY236
D	SER237
D	HOH408
D	HOH567

site_id	AI3
Number of Residues	6
Details	binding site for residue SO4 D 302

Chain	Residue
D	THR104
D	TRP105
D	ASN132
D	HIS170
D	HOH448
D	HOH483

site_id	AI4
Number of Residues	4
Details	binding site for residue SO4 D 303

Chain	Residue
D	LYS124
D	ARG129
D	HOH445
D	HOH465

site_id	AI5
Number of Residues	3
Details	binding site for residue SO4 D 304

Chain	Residue
D	PRO226
D	ASP227
D	HOH407

site_id	AI6
Number of Residues	2
Details	binding site for residue SO4 D 305

Chain	Residue
D	LYS201
D	HOH428

site_id	AI7
Number of Residues	3
Details	binding site for residue SO4 D 306

Chain	Residue
D	ARG129
D	THR215
D	HOH421

site_id	AI8
Number of Residues	2
Details	binding site for residue CL D 307

Chain	Residue
D	THR145
D	HOH498

site_id	AI9
Number of Residues	5
Details	binding site for residue CL D 308

Chain	Residue
D	PHE193
D	ASN196
D	GLU197
D	ILE198
D	LEU199

site_id	AJ1
Number of Residues	4
Details	binding site for residue ACT D 309

Chain	Residue
D	ASP92
D	SER118
D	HOH402
D	HOH403

site_id	AJ2
Number of Residues	3
Details	binding site for residue ACT D 310

Chain	Residue
A	HOH401
D	LYS93
D	LYS94

site_id	AJ3
Number of Residues	3
Details	binding site for residue ACT D 311

Chain	Residue
D	SER153
D	LYS158
D	ASN159

site_id	AJ4
Number of Residues	4
Details	binding site for residue ACT D 312

Chain	Residue
C	HOH471
C	HOH505
D	HOH444
D	HOH575

site_id	AJ5
Number of Residues	4
Details	binding site for residue ACT D 313

Chain	Residue
D	GLY217
D	HOH412
D	HOH435
D	HOH640

site_id	AJ6
Number of Residues	6
Details	binding site for residue ACT D 314

Chain	Residue
D	LYS30
D	GLU34
D	ASN59
D	ASN61
D	GLU62
D	HOH415

site_id	AJ7
Number of Residues	4
Details	binding site for residue ACT D 315

Chain	Residue
C	LYS93
D	LYS270
D	SER271
D	HOH410

site_id	AJ8
Number of Residues	4
Details	binding site for residue ACT D 316

Chain	Residue
C	ASN88
D	LYS270
D	ASP272
D	HOH462

site_id	AJ9
Number of Residues	2
Details	binding site for residue ACT D 317

Chain	Residue
D	ASP227
D	GLY228

site_id	AK1
Number of Residues	3
Details	binding site for residue ACT D 318

Chain	Residue
D	GLY25
D	THR26
D	TYR288

site_id	AK2
Number of Residues	2
Details	binding site for residue ACT D 319

Chain	Residue
D	LYS195
D	HOH598

site_id	AK3
Number of Residues	3
Details	binding site for residue ACT D 320

Chain	Residue
A	HIS170
A	LYS171
D	ASN114

Functional Information from PROSITE/UniProt

site_id	PS00146
Number of Residues	16
Details	BETA_LACTAMASE_A Beta-lactamase class-A active site. YpMQSTyKfhlALAVL

Chain	Residue	Details
A	TYR66-LEU81

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)