6NUR

SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016740	molecular_function	transferase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016740	molecular_function	transferase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS295
A	CYS301
A	CYS306
A	CYS310

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS487
A	HIS642
A	CYS645
A	CYS646

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM

Chain	Residue	Details
A	GLY590-MET601

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Domain: {"description":"Nsp12 Interface","evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	162
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	214
Details	Region: {"description":"RdRp Fingers N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	Region: {"description":"RdRp Palm N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	58
Details	Region: {"description":"RdRp Fingers C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	135
Details	Region: {"description":"RdRp Palm C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0DTD1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

---