6NUC
Structure of Calcineurin in complex with NHE1 peptide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016787 | molecular_function | hydrolase activity |
A | 0033192 | molecular_function | calmodulin-dependent protein phosphatase activity |
A | 0097720 | biological_process | calcineurin-mediated signaling |
B | 0001569 | biological_process | branching involved in blood vessel morphogenesis |
B | 0001837 | biological_process | epithelial to mesenchymal transition |
B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
B | 0004723 | molecular_function | calcium-dependent protein serine/threonine phosphatase activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0005515 | molecular_function | protein binding |
B | 0005516 | molecular_function | calmodulin binding |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0005955 | cellular_component | calcineurin complex |
B | 0006606 | biological_process | protein import into nucleus |
B | 0007507 | biological_process | heart development |
B | 0008287 | cellular_component | protein serine/threonine phosphatase complex |
B | 0008597 | molecular_function | calcium-dependent protein serine/threonine phosphatase regulator activity |
B | 0014044 | biological_process | Schwann cell development |
B | 0016018 | molecular_function | cyclosporin A binding |
B | 0019902 | molecular_function | phosphatase binding |
B | 0019904 | molecular_function | protein domain specific binding |
B | 0022011 | biological_process | myelination in peripheral nervous system |
B | 0033173 | biological_process | calcineurin-NFAT signaling cascade |
B | 0034504 | biological_process | protein localization to nucleus |
B | 0042383 | cellular_component | sarcolemma |
B | 0045202 | cellular_component | synapse |
B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
B | 0046872 | molecular_function | metal ion binding |
B | 0060487 | biological_process | lung epithelial cell differentiation |
B | 0070886 | biological_process | positive regulation of calcineurin-NFAT signaling cascade |
B | 0097720 | biological_process | calcineurin-mediated signaling |
B | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
B | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
B | 0098688 | cellular_component | parallel fiber to Purkinje cell synapse |
B | 0098693 | biological_process | regulation of synaptic vesicle cycle |
B | 0098794 | cellular_component | postsynapse |
B | 0098978 | cellular_component | glutamatergic synapse |
B | 0099149 | biological_process | regulation of postsynaptic neurotransmitter receptor internalization |
B | 0099170 | biological_process | postsynaptic modulation of chemical synaptic transmission |
B | 1905665 | biological_process | positive regulation of calcium ion import across plasma membrane |
B | 1905949 | biological_process | negative regulation of calcium ion import across plasma membrane |
C | 0006814 | biological_process | sodium ion transport |
C | 0006885 | biological_process | regulation of pH |
C | 0015385 | molecular_function | sodium:proton antiporter activity |
C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue FE A 401 |
Chain | Residue |
A | ASP90 |
A | HIS92 |
A | ASP118 |
A | ZN402 |
A | PO4403 |
A | HOH525 |
A | HOH621 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue ZN A 402 |
Chain | Residue |
A | HIS199 |
A | HIS281 |
A | FE401 |
A | PO4403 |
A | HOH525 |
A | ASP118 |
A | ASN150 |
site_id | AC3 |
Number of Residues | 13 |
Details | binding site for residue PO4 A 403 |
Chain | Residue |
A | HIS92 |
A | ASP118 |
A | ARG122 |
A | ASN150 |
A | HIS151 |
A | ARG254 |
A | HIS281 |
A | FE401 |
A | ZN402 |
A | HOH519 |
A | HOH525 |
A | HOH621 |
A | HOH645 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue PEG A 404 |
Chain | Residue |
A | ALA109 |
A | ASN110 |
A | THR111 |
A | ARG112 |
A | THR143 |
A | HOH724 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue NA A 405 |
Chain | Residue |
A | GLU172 |
A | ASP176 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue CA B 201 |
Chain | Residue |
B | ASP63 |
B | ASP65 |
B | ASN67 |
B | GLU69 |
B | GLU74 |
B | HOH310 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue CA B 202 |
Chain | Residue |
B | ASP141 |
B | ASP143 |
B | ASP145 |
B | ARG147 |
B | GLU152 |
B | HOH321 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue CA B 203 |
Chain | Residue |
B | ASP31 |
B | ASP33 |
B | SER35 |
B | SER37 |
B | GLU42 |
B | HOH372 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue CA B 204 |
Chain | Residue |
B | ASP100 |
B | ASP102 |
B | ASP104 |
B | TYR106 |
B | GLU111 |
B | HOH317 |
Functional Information from PROSITE/UniProt
site_id | PS00125 |
Number of Residues | 6 |
Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
Chain | Residue | Details |
A | LEU147-GLU152 |
site_id | PS00018 |
Number of Residues | 13 |
Details | EF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF |
Chain | Residue | Details |
B | ASP31-PHE43 | |
B | ASP63-PHE75 | |
B | ASP100-LEU112 | |
B | ASP141-PHE153 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
C | SER693 | |
B | GLU74 | |
B | ASP141 | |
B | ASP143 | |
B | ASP145 | |
B | ARG147 | |
B | GLU152 | |
B | ASP33 | |
B | SER35 | |
B | SER37 | |
B | GLU42 | |
B | ASP63 | |
B | ASP65 | |
B | ASN67 | |
B | GLU69 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
C | SER697 | |
C | SER723 | |
B | ASP104 | |
B | TYR106 | |
B | GLU111 | |
A | HIS281 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
C | SER703 | |
B | ASN122 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q63810 |
Chain | Residue | Details |
B | TYR106 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P63328 |
Chain | Residue | Details |
A | TYR224 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 10 |
Details | M-CSA 406 |
Chain | Residue | Details |
A | ASP90 | metal ligand |
A | HIS281 | metal ligand |
A | HIS92 | metal ligand |
A | ASP118 | metal ligand |
A | ASP121 | electrostatic stabiliser |
A | ARG122 | transition state stabiliser |
A | ASN150 | metal ligand |
A | HIS151 | proton shuttle (general acid/base) |
A | HIS199 | metal ligand |
A | ARG254 | transition state stabiliser |