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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6NU6

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 5

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0004141molecular_functiondethiobiotin synthase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0009102biological_processbiotin biosynthetic process
A0016874molecular_functionligase activity
A0046872molecular_functionmetal ion binding
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0004141molecular_functiondethiobiotin synthase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0009102biological_processbiotin biosynthetic process
B0016874molecular_functionligase activity
B0046872molecular_functionmetal ion binding
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0004141molecular_functiondethiobiotin synthase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0009102biological_processbiotin biosynthetic process
C0016874molecular_functionligase activity
C0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0004141molecular_functiondethiobiotin synthase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0009102biological_processbiotin biosynthetic process
D0016874molecular_functionligase activity
D0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue L1V A 301
ChainResidue
ATHR11
AL1Y302
ASO4303
AHOH401
AHOH421
BLEU143
BGLY144
BTHR145
BLEU146
BASN147
BHOH418
ALYS15
ATHR41
AARG45
AASP47
APRO71
AMET72
AGLY111
AVAL115
site_idAC2
Number of Residues20
Detailsbinding site for residue L1Y A 302
ChainResidue
ATHR11
ALYS15
ATHR41
AARG45
APRO71
AMET72
APRO74
AALA110
AGLY111
AVAL115
AL1V301
ASO4303
AHOH401
AHOH421
BLEU143
BGLY144
BTHR145
BLEU146
BASN147
BHOH418
site_idAC3
Number of Residues7
Detailsbinding site for residue SO4 A 303
ChainResidue
AGLY12
AVAL13
AGLY14
ALYS15
ATHR16
AL1V301
AL1Y302
site_idAC4
Number of Residues20
Detailsbinding site for residue L1V B 301
ChainResidue
ALEU143
AGLY144
ATHR145
ALEU146
AASN147
BTHR11
BLYS15
BTHR41
BASP47
BPRO71
BMET72
BALA73
BALA110
BGLY111
BVAL115
BL1Y302
BSO4303
BHOH402
BHOH403
BHOH409
site_idAC5
Number of Residues20
Detailsbinding site for residue L1Y B 302
ChainResidue
ALEU143
AGLY144
ATHR145
ALEU146
AASN147
BTHR11
BLYS15
BTHR41
BARG45
BPRO71
BMET72
BALA73
BALA110
BGLY111
BVAL115
BL1V301
BSO4303
BHOH402
BHOH403
BHOH409
site_idAC6
Number of Residues8
Detailsbinding site for residue SO4 B 303
ChainResidue
BGLY12
BVAL13
BGLY14
BLYS15
BTHR16
BL1V301
BL1Y302
BHOH402
site_idAC7
Number of Residues18
Detailsbinding site for residue L1V C 301
ChainResidue
CPRO71
CMET72
CALA73
CGLY111
CL1Y302
CSO4303
CHOH402
CHOH413
DLEU143
DGLY144
DTHR145
DLEU146
DASN147
CTHR11
CLYS15
CTHR41
CARG45
CASP47
site_idAC8
Number of Residues18
Detailsbinding site for residue L1Y C 302
ChainResidue
CTHR11
CLYS15
CTHR41
CARG45
CPRO71
CMET72
CALA73
CALA110
CGLY111
CL1V301
CSO4303
CHOH402
CHOH413
DLEU143
DGLY144
DTHR145
DLEU146
DASN147
site_idAC9
Number of Residues8
Detailsbinding site for residue SO4 C 303
ChainResidue
CGLY12
CVAL13
CGLY14
CLYS15
CTHR16
CL1V301
CL1Y302
CHOH402
site_idAD1
Number of Residues17
Detailsbinding site for residue L1V D 301
ChainResidue
CLEU143
CGLY144
CTHR145
CLEU146
CASN147
DTHR11
DGLY12
DLYS15
DTHR41
DASP47
DALA110
DGLY111
DVAL115
DL1Y302
DSO4303
DHOH407
DHOH420
site_idAD2
Number of Residues19
Detailsbinding site for residue L1Y D 302
ChainResidue
CLEU143
CGLY144
CTHR145
CLEU146
CASN147
DTHR11
DGLY12
DLYS15
DTHR41
DARG45
DPRO71
DMET72
DALA110
DGLY111
DVAL115
DL1V301
DSO4303
DHOH407
DHOH420
site_idAD3
Number of Residues8
Detailsbinding site for residue SO4 D 303
ChainResidue
DGLY12
DVAL13
DGLY14
DLYS15
DTHR16
DL1V301
DL1Y302
DHOH401
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25801336","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30289406","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2018","firstPage":"10774","lastPage":"10783","volume":"8","journal":"ACS Catal.","title":"Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes.","authors":["Thompson A.P.","Salaemae W.","Pederick J.L.","Abell A.D.","Booker G.W.","Bruning J.B.","Polyak S.W."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.8b03475"}]}},{"source":"PDB","id":"4WOP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E06","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20565114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30289406","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2018","firstPage":"10774","lastPage":"10783","volume":"8","journal":"ACS Catal.","title":"Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes.","authors":["Thompson A.P.","Salaemae W.","Pederick J.L.","Abell A.D.","Booker G.W.","Bruning J.B.","Polyak S.W."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.8b03475"}]}},{"source":"PDB","id":"3FPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E06","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20565114","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2018","firstPage":"10774","lastPage":"10783","volume":"8","journal":"ACS Catal.","title":"Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes.","authors":["Thompson A.P.","Salaemae W.","Pederick J.L.","Abell A.D.","Booker G.W.","Bruning J.B.","Polyak S.W."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.8b03475"}]}},{"source":"PDB","id":"3FMF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20565114","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2018","firstPage":"10774","lastPage":"10783","volume":"8","journal":"ACS Catal.","title":"Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes.","authors":["Thompson A.P.","Salaemae W.","Pederick J.L.","Abell A.D.","Booker G.W.","Bruning J.B.","Polyak S.W."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.8b03475"}]}},{"source":"PDB","id":"3FMF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30289406","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2018","firstPage":"10774","lastPage":"10783","volume":"8","journal":"ACS Catal.","title":"Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes.","authors":["Thompson A.P.","Salaemae W.","Pederick J.L.","Abell A.D.","Booker G.W.","Bruning J.B.","Polyak S.W."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.8b03475"}]}},{"source":"PDB","id":"6CVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E06","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-12-17

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