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6NT8

Cryo-EM structure of full-length chicken STING in the cGAMP-bound tetrameric state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000421cellular_componentautophagosome membrane
A0002218biological_processactivation of innate immune response
A0005737cellular_componentcytoplasm
A0005776cellular_componentautophagosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0006914biological_processautophagy
A0015252molecular_functionproton channel activity
A0016020cellular_componentmembrane
A0016239biological_processpositive regulation of macroautophagy
A0031410cellular_componentcytoplasmic vesicle
A0032481biological_processpositive regulation of type I interferon production
A0032728biological_processpositive regulation of interferon-beta production
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035438molecular_functioncyclic-di-GMP binding
A0042803molecular_functionprotein homodimerization activity
A0045087biological_processinnate immune response
A0048471cellular_componentperinuclear region of cytoplasm
A0051259biological_processprotein complex oligomerization
A0051607biological_processdefense response to virus
A0061507molecular_function2',3'-cyclic GMP-AMP binding
A0061709biological_processreticulophagy
A0140896biological_processcGAS/STING signaling pathway
A1902600biological_processproton transmembrane transport
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000421cellular_componentautophagosome membrane
B0002218biological_processactivation of innate immune response
B0005737cellular_componentcytoplasm
B0005776cellular_componentautophagosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0006914biological_processautophagy
B0015252molecular_functionproton channel activity
B0016020cellular_componentmembrane
B0016239biological_processpositive regulation of macroautophagy
B0031410cellular_componentcytoplasmic vesicle
B0032481biological_processpositive regulation of type I interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035438molecular_functioncyclic-di-GMP binding
B0042803molecular_functionprotein homodimerization activity
B0045087biological_processinnate immune response
B0048471cellular_componentperinuclear region of cytoplasm
B0051259biological_processprotein complex oligomerization
B0051607biological_processdefense response to virus
B0061507molecular_function2',3'-cyclic GMP-AMP binding
B0061709biological_processreticulophagy
B0140896biological_processcGAS/STING signaling pathway
B1902600biological_processproton transmembrane transport
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000421cellular_componentautophagosome membrane
D0002218biological_processactivation of innate immune response
D0005737cellular_componentcytoplasm
D0005776cellular_componentautophagosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0006914biological_processautophagy
D0015252molecular_functionproton channel activity
D0016020cellular_componentmembrane
D0016239biological_processpositive regulation of macroautophagy
D0031410cellular_componentcytoplasmic vesicle
D0032481biological_processpositive regulation of type I interferon production
D0032728biological_processpositive regulation of interferon-beta production
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0035438molecular_functioncyclic-di-GMP binding
D0042803molecular_functionprotein homodimerization activity
D0045087biological_processinnate immune response
D0048471cellular_componentperinuclear region of cytoplasm
D0051259biological_processprotein complex oligomerization
D0051607biological_processdefense response to virus
D0061507molecular_function2',3'-cyclic GMP-AMP binding
D0061709biological_processreticulophagy
D0140896biological_processcGAS/STING signaling pathway
D1902600biological_processproton transmembrane transport
E0000045biological_processautophagosome assembly
E0000139cellular_componentGolgi membrane
E0000166molecular_functionnucleotide binding
E0000421cellular_componentautophagosome membrane
E0002218biological_processactivation of innate immune response
E0005737cellular_componentcytoplasm
E0005776cellular_componentautophagosome
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005794cellular_componentGolgi apparatus
E0006914biological_processautophagy
E0015252molecular_functionproton channel activity
E0016020cellular_componentmembrane
E0016239biological_processpositive regulation of macroautophagy
E0031410cellular_componentcytoplasmic vesicle
E0032481biological_processpositive regulation of type I interferon production
E0032728biological_processpositive regulation of interferon-beta production
E0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0035438molecular_functioncyclic-di-GMP binding
E0042803molecular_functionprotein homodimerization activity
E0045087biological_processinnate immune response
E0048471cellular_componentperinuclear region of cytoplasm
E0051259biological_processprotein complex oligomerization
E0051607biological_processdefense response to virus
E0061507molecular_function2',3'-cyclic GMP-AMP binding
E0061709biological_processreticulophagy
E0140896biological_processcGAS/STING signaling pathway
E1902600biological_processproton transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue 1SY A 401
ChainResidue
ASER167
BVAL244
BTYR245
BSER268
ATYR172
AARG243
AGLU265
ASER268
BTYR168
BTYR172
BILE240
BARG243

site_idAC2
Number of Residues12
Detailsbinding site for residue 1SY D 401
ChainResidue
DSER167
DTYR172
DARG243
DGLU265
DSER268
ETYR168
ETYR172
EILE240
EARG243
EVAL244
ETYR245
ESER268

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1128
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30842659
ChainResidueDetails
AMET1-ARG23
EMET1-ARG23
EILE76-PRO97
EGLY140-PRO379
AILE76-PRO97
AGLY140-PRO379
BMET1-ARG23
BILE76-PRO97
BGLY140-PRO379
DMET1-ARG23
DILE76-PRO97
DGLY140-PRO379

site_idSWS_FT_FI2
Number of Residues64
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AALA24-PHE40
BALA24-PHE40
DALA24-PHE40
EALA24-PHE40

site_idSWS_FT_FI3
Number of Residues72
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:30842659
ChainResidueDetails
ALEU41-ILE50
ALEU112-SER121
BLEU41-ILE50
BLEU112-SER121
DLEU41-ILE50
DLEU112-SER121
ELEU41-ILE50
ELEU112-SER121

site_idSWS_FT_FI4
Number of Residues96
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AARG51-GLU75
BARG51-GLU75
DARG51-GLU75
EARG51-GLU75

site_idSWS_FT_FI5
Number of Residues52
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AARG98-TYR111
BARG98-TYR111
DARG98-TYR111
EARG98-TYR111

site_idSWS_FT_FI6
Number of Residues68
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30842659
ChainResidueDetails
APRO122-LEU139
BPRO122-LEU139
DPRO122-LEU139
EPRO122-LEU139

site_idSWS_FT_FI7
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q86WV6
ChainResidueDetails
ASER167
DTYR172
DARG243
DSER268
ESER167
ETYR172
EARG243
ESER268
ATYR172
AARG243
ASER268
BSER167
BTYR172
BARG243
BSER268
DSER167

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000305|PubMed:30842653
ChainResidueDetails
ASER366
BSER366
DSER366
ESER366

227111

PDB entries from 2024-11-06

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