6NT6

Cryo-EM structure of full-length chicken STING in the apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000421	cellular_component	autophagosome membrane
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006811	biological_process	monoatomic ion transport
A	0006914	biological_process	autophagy
A	0015252	molecular_function	proton channel activity
A	0016239	biological_process	positive regulation of macroautophagy
A	0031410	cellular_component	cytoplasmic vesicle
A	0032481	biological_process	positive regulation of type I interferon production
A	0032728	biological_process	positive regulation of interferon-beta production
A	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035438	molecular_function	cyclic-di-GMP binding
A	0042803	molecular_function	protein homodimerization activity
A	0045087	biological_process	innate immune response
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051259	biological_process	protein complex oligomerization
A	0051607	biological_process	defense response to virus
A	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
A	0061709	biological_process	reticulophagy
A	0140896	biological_process	cGAS/STING signaling pathway
A	1902600	biological_process	proton transmembrane transport
B	0000045	biological_process	autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000421	cellular_component	autophagosome membrane
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0005737	cellular_component	cytoplasm
B	0005776	cellular_component	autophagosome
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006811	biological_process	monoatomic ion transport
B	0006914	biological_process	autophagy
B	0015252	molecular_function	proton channel activity
B	0016239	biological_process	positive regulation of macroautophagy
B	0031410	cellular_component	cytoplasmic vesicle
B	0032481	biological_process	positive regulation of type I interferon production
B	0032728	biological_process	positive regulation of interferon-beta production
B	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035438	molecular_function	cyclic-di-GMP binding
B	0042803	molecular_function	protein homodimerization activity
B	0045087	biological_process	innate immune response
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051259	biological_process	protein complex oligomerization
B	0051607	biological_process	defense response to virus
B	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
B	0061709	biological_process	reticulophagy
B	0140896	biological_process	cGAS/STING signaling pathway
B	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q86WV6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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