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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6NT5

Cryo-EM structure of full-length human STING in the apo state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000421cellular_componentautophagosome membrane
A0002218biological_processactivation of innate immune response
A0002221biological_processpattern recognition receptor signaling pathway
A0002230biological_processpositive regulation of defense response to virus by host
A0002376biological_processimmune system process
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003713molecular_functiontranscription coactivator activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005768cellular_componentendosome
A0005776cellular_componentautophagosome
A0005777cellular_componentperoxisome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006811biological_processmonoatomic ion transport
A0006914biological_processautophagy
A0010468biological_processregulation of gene expression
A0015252molecular_functionproton channel activity
A0016239biological_processpositive regulation of macroautophagy
A0019901molecular_functionprotein kinase binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032481biological_processpositive regulation of type I interferon production
A0032728biological_processpositive regulation of interferon-beta production
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035438molecular_functioncyclic-di-GMP binding
A0035458biological_processcellular response to interferon-beta
A0035591molecular_functionsignaling adaptor activity
A0036064cellular_componentciliary basal body
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048471cellular_componentperinuclear region of cytoplasm
A0050727biological_processregulation of inflammatory response
A0051259biological_processprotein complex oligomerization
A0051607biological_processdefense response to virus
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0061507molecular_function2',3'-cyclic GMP-AMP binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0061709biological_processreticulophagy
A0070972biological_processprotein localization to endoplasmic reticulum
A0071360biological_processcellular response to exogenous dsRNA
A0120283molecular_functionprotein serine/threonine kinase binding
A0140374biological_processantiviral innate immune response
A0140896biological_processcGAS/STING signaling pathway
A1902554cellular_componentserine/threonine protein kinase complex
A1902600biological_processproton transmembrane transport
A1990231cellular_componentSTING complex
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000421cellular_componentautophagosome membrane
B0002218biological_processactivation of innate immune response
B0002221biological_processpattern recognition receptor signaling pathway
B0002230biological_processpositive regulation of defense response to virus by host
B0002376biological_processimmune system process
B0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
B0003713molecular_functiontranscription coactivator activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005768cellular_componentendosome
B0005776cellular_componentautophagosome
B0005777cellular_componentperoxisome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006811biological_processmonoatomic ion transport
B0006914biological_processautophagy
B0010468biological_processregulation of gene expression
B0015252molecular_functionproton channel activity
B0016239biological_processpositive regulation of macroautophagy
B0019901molecular_functionprotein kinase binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032481biological_processpositive regulation of type I interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035438molecular_functioncyclic-di-GMP binding
B0035458biological_processcellular response to interferon-beta
B0035591molecular_functionsignaling adaptor activity
B0036064cellular_componentciliary basal body
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0045087biological_processinnate immune response
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048471cellular_componentperinuclear region of cytoplasm
B0050727biological_processregulation of inflammatory response
B0051259biological_processprotein complex oligomerization
B0051607biological_processdefense response to virus
B0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
B0061507molecular_function2',3'-cyclic GMP-AMP binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061709biological_processreticulophagy
B0070972biological_processprotein localization to endoplasmic reticulum
B0071360biological_processcellular response to exogenous dsRNA
B0120283molecular_functionprotein serine/threonine kinase binding
B0140374biological_processantiviral innate immune response
B0140896biological_processcGAS/STING signaling pathway
B1902554cellular_componentserine/threonine protein kinase complex
B1902600biological_processproton transmembrane transport
B1990231cellular_componentSTING complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues28
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q3TBT3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"29973723","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31968013","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19285439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21074459","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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