Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NST

Crystal structure of branched chain amino acid aminotransferase from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004084	molecular_function	branched-chain-amino-acid transaminase activity
A	0005829	cellular_component	cytosol
A	0006532	biological_process	aspartate biosynthetic process
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009098	biological_process	L-leucine biosynthetic process
A	0009099	biological_process	valine biosynthetic process
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
A	0052654	molecular_function	L-leucine transaminase activity
A	0052655	molecular_function	L-valine transaminase activity
A	0052656	molecular_function	L-isoleucine transaminase activity
B	0003824	molecular_function	catalytic activity
B	0004084	molecular_function	branched-chain-amino-acid transaminase activity
B	0005829	cellular_component	cytosol
B	0006532	biological_process	aspartate biosynthetic process
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009098	biological_process	L-leucine biosynthetic process
B	0009099	biological_process	valine biosynthetic process
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
B	0052654	molecular_function	L-leucine transaminase activity
B	0052655	molecular_function	L-valine transaminase activity
B	0052656	molecular_function	L-isoleucine transaminase activity
C	0003824	molecular_function	catalytic activity
C	0004084	molecular_function	branched-chain-amino-acid transaminase activity
C	0005829	cellular_component	cytosol
C	0006532	biological_process	aspartate biosynthetic process
C	0008483	molecular_function	transaminase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009098	biological_process	L-leucine biosynthetic process
C	0009099	biological_process	valine biosynthetic process
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
C	0052654	molecular_function	L-leucine transaminase activity
C	0052655	molecular_function	L-valine transaminase activity
C	0052656	molecular_function	L-isoleucine transaminase activity
D	0003824	molecular_function	catalytic activity
D	0004084	molecular_function	branched-chain-amino-acid transaminase activity
D	0005829	cellular_component	cytosol
D	0006532	biological_process	aspartate biosynthetic process
D	0008483	molecular_function	transaminase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009081	biological_process	branched-chain amino acid metabolic process
D	0009082	biological_process	branched-chain amino acid biosynthetic process
D	0009097	biological_process	isoleucine biosynthetic process
D	0009098	biological_process	L-leucine biosynthetic process
D	0009099	biological_process	valine biosynthetic process
D	0046394	biological_process	carboxylic acid biosynthetic process
D	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
D	0052654	molecular_function	L-leucine transaminase activity
D	0052655	molecular_function	L-valine transaminase activity
D	0052656	molecular_function	L-isoleucine transaminase activity
E	0003824	molecular_function	catalytic activity
E	0004084	molecular_function	branched-chain-amino-acid transaminase activity
E	0005829	cellular_component	cytosol
E	0006532	biological_process	aspartate biosynthetic process
E	0008483	molecular_function	transaminase activity
E	0008652	biological_process	amino acid biosynthetic process
E	0009081	biological_process	branched-chain amino acid metabolic process
E	0009082	biological_process	branched-chain amino acid biosynthetic process
E	0009097	biological_process	isoleucine biosynthetic process
E	0009098	biological_process	L-leucine biosynthetic process
E	0009099	biological_process	valine biosynthetic process
E	0046394	biological_process	carboxylic acid biosynthetic process
E	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
E	0052654	molecular_function	L-leucine transaminase activity
E	0052655	molecular_function	L-valine transaminase activity
E	0052656	molecular_function	L-isoleucine transaminase activity
F	0003824	molecular_function	catalytic activity
F	0004084	molecular_function	branched-chain-amino-acid transaminase activity
F	0005829	cellular_component	cytosol
F	0006532	biological_process	aspartate biosynthetic process
F	0008483	molecular_function	transaminase activity
F	0008652	biological_process	amino acid biosynthetic process
F	0009081	biological_process	branched-chain amino acid metabolic process
F	0009082	biological_process	branched-chain amino acid biosynthetic process
F	0009097	biological_process	isoleucine biosynthetic process
F	0009098	biological_process	L-leucine biosynthetic process
F	0009099	biological_process	valine biosynthetic process
F	0046394	biological_process	carboxylic acid biosynthetic process
F	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
F	0052654	molecular_function	L-leucine transaminase activity
F	0052655	molecular_function	L-valine transaminase activity
F	0052656	molecular_function	L-isoleucine transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 401

Chain	Residue
A	ARG61
A	GLY219
A	ILE220
A	THR221
A	GLY256
A	THR257
A	HOH513
A	HOH541

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 B 401

Chain	Residue
B	GLY219
B	ILE220
B	THR221
B	THR257
B	HOH508
B	HOH510
B	HOH544
B	ARG61

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 C 401

Chain	Residue
C	ARG61
C	GLY219
C	ILE220
C	THR221
C	THR257
C	HOH507
C	HOH509

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 D 401

Chain	Residue
D	ARG61
D	GLY219
D	ILE220
D	THR221
D	THR257
D	HOH512

site_id	AC5
Number of Residues	8
Details	binding site for residue SO4 E 401

Chain	Residue
E	ARG61
E	GLY219
E	ILE220
E	THR221
E	GLY256
E	THR257
E	HOH514
E	HOH523

site_id	AC6
Number of Residues	9
Details	binding site for residue SO4 F 401

Chain	Residue
F	ARG61
F	GLY219
F	ILE220
F	THR221
F	GLY256
F	THR257
F	HOH513
F	HOH524
F	HOH534

Functional Information from PROSITE/UniProt

site_id	PS00770
Number of Residues	29
Details	AA_TRANSFER_CLASS_4 Aminotransferases class-IV signature. EgSgeNIFiikdgv......IyTpevtac..LnGItR

Chain	Residue	Details
A	GLU194-ARG222

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250

Chain	Residue	Details
A	LYS160
B	LYS160
C	LYS160
D	LYS160
E	LYS160
F	LYS160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)