6NS7

Crystal structure of murine caspase-11

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 401

Chain	Residue
A	ARG148
A	GLN252
A	ARG310

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 B 401

Chain	Residue
B	ARG148
B	GLN252
B	ARG310

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site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 C 401

Chain	Residue
C	HOH510
C	ARG148
C	GLN252
C	ARG310

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site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 D 401

Chain	Residue
D	ARG148
D	GLN252
D	SER308
D	ARG310
D	HOH504
D	HOH505

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Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HqtsdStfLvLMSHG

Chain	Residue	Details
A	HIS193-GLY207

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P29466

Chain	Residue	Details
A	HIS206
B	HIS206
C	HIS206
D	HIS206

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P49662

Chain	Residue	Details
A	ALA254
B	ALA254
C	ALA254
D	ALA254

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:30135078

Chain	Residue	Details
A	ASP285
B	ASP285
C	ASP285
D	ASP285

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:34671164

Chain	Residue	Details
A	ARG310
B	ARG310
C	ARG310
D	ARG310

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