6NRY

Crystal structure of human caspase-4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 401

Chain	Residue
A	ILE212
A	LEU213
A	TYR231
A	ARG259
A	CYS304
A	SER306
A	GLU363

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Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HkssdStfLvLMSHG

Chain	Residue	Details
A	HIS197-GLY211

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P29466

Chain	Residue	Details
A	HIS210

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7743998

Chain	Residue	Details
A	ALA258

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7797510

Chain	Residue	Details
A	ASP289

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:36624349

Chain	Residue	Details
A	ARG314

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