6NRI

Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT83

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue KYM A 1101

Chain	Residue
A	HIS862
A	TYR907
A	HOH1205
A	HOH1226
A	HOH1247
A	GLY863
A	ARG865
A	ASN868
A	GLY888
A	TYR889
A	TYR896
A	PHE897
A	SER904

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site_id	AC2
Number of Residues	9
Details	binding site for residue CIT A 1102

Chain	Residue
A	LYS766
A	HIS826
A	LYS903
A	TYR907
A	LEU984
A	LEU985
A	TYR986
A	HOH1201
A	HOH1227

---

site_id	AC3
Number of Residues	7
Details	binding site for residue DMS A 1103

Chain	Residue
A	HIS862
A	ARG878
A	TYR889
A	GLY894
A	ILE895
A	TYR896
A	HOH1247

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851

Chain	Residue	Details
A	GLU988

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9UGN5

Chain	Residue	Details
A	HIS862
A	GLY871
A	ARG878
A	SER904

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