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6NQ1

Cryo-EM structure of human TPC2 channel in the apo state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005248molecular_functionvoltage-gated sodium channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005829cellular_componentcytosol
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006939biological_processsmooth muscle contraction
A0007040biological_processlysosome organization
A0010008cellular_componentendosome membrane
A0010506biological_processregulation of autophagy
A0015280molecular_functionligand-gated sodium channel activity
A0016020cellular_componentmembrane
A0017157biological_processregulation of exocytosis
A0019065biological_processreceptor-mediated endocytosis of virus by host cell
A0019722biological_processcalcium-mediated signaling
A0019901molecular_functionprotein kinase binding
A0022832molecular_functionvoltage-gated channel activity
A0031902cellular_componentlate endosome membrane
A0033162cellular_componentmelanosome membrane
A0033280biological_processresponse to vitamin D
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0035725biological_processsodium ion transmembrane transport
A0036020cellular_componentendolysosome membrane
A0042802molecular_functionidentical protein binding
A0048086biological_processnegative regulation of developmental pigmentation
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051452biological_processintracellular pH reduction
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0072345molecular_functionNAADP-sensitive calcium-release channel activity
A0075509biological_processendocytosis involved in viral entry into host cell
A0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
A0090117biological_processendosome to lysosome transport of low-density lipoprotein particle
A0097682molecular_functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
B0005216molecular_functionmonoatomic ion channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005248molecular_functionvoltage-gated sodium channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005829cellular_componentcytosol
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006939biological_processsmooth muscle contraction
B0007040biological_processlysosome organization
B0010008cellular_componentendosome membrane
B0010506biological_processregulation of autophagy
B0015280molecular_functionligand-gated sodium channel activity
B0016020cellular_componentmembrane
B0017157biological_processregulation of exocytosis
B0019065biological_processreceptor-mediated endocytosis of virus by host cell
B0019722biological_processcalcium-mediated signaling
B0019901molecular_functionprotein kinase binding
B0022832molecular_functionvoltage-gated channel activity
B0031902cellular_componentlate endosome membrane
B0033162cellular_componentmelanosome membrane
B0033280biological_processresponse to vitamin D
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0035725biological_processsodium ion transmembrane transport
B0036020cellular_componentendolysosome membrane
B0042802molecular_functionidentical protein binding
B0048086biological_processnegative regulation of developmental pigmentation
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051452biological_processintracellular pH reduction
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0072345molecular_functionNAADP-sensitive calcium-release channel activity
B0075509biological_processendocytosis involved in viral entry into host cell
B0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
B0090117biological_processendosome to lysosome transport of low-density lipoprotein particle
B0097682molecular_functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues110
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues76
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues92
DetailsIntramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues8
DetailsRegion: {"description":"Interaction with phosphatidylinositol 3,5-bisphosphate","evidences":[{"source":"PubMed","id":"30860481","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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