Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 601 |
| Chain | Residue |
| A | ARG492 |
| A | GLN496 |
| A | HOH707 |
| A | HOH812 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue STI A 602 |
| Chain | Residue |
| A | ILE312 |
| A | VAL318 |
| A | THR334 |
| A | MET337 |
| A | ILE379 |
| A | HIS380 |
| A | ALA399 |
| A | ASP400 |
| A | PHE401 |
| A | HOH781 |
| A | LEU267 |
| A | ALA288 |
| A | LYS290 |
| A | GLU305 |
| A | MET309 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue KWP A 603 |
| Chain | Residue |
| A | ARG351 |
| A | ALA356 |
| A | ALA363 |
| A | LEU448 |
| A | ILE451 |
| A | ALA452 |
| A | TYR454 |
| A | GLU481 |
| A | GLY482 |
| A | PRO484 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 601 |
| Chain | Residue |
| A | ARG326 |
| A | ARG479 |
| A | GLU481 |
| A | GLY482 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 602 |
| Chain | Residue |
| A | LYS473 |
| B | LYS313 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue STI B 603 |
| Chain | Residue |
| B | LEU267 |
| B | ALA288 |
| B | LYS290 |
| B | GLU305 |
| B | MET309 |
| B | ILE312 |
| B | VAL318 |
| B | THR334 |
| B | PHE336 |
| B | MET337 |
| B | ILE379 |
| B | HIS380 |
| B | ALA399 |
| B | ASP400 |
| B | PHE401 |
| B | HOH786 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | ASP474 |
| B | ARG476 |
| B | ARG492 |
| B | TRP495 |
| B | HOH764 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | LYS313 |
| B | HIS314 |
| B | PRO315 |
| B | LEU471 |
| B | GLU472 |
| B | ASP474 |
| B | ARG476 |
| B | TRP497 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue 2PE B 606 |
| Chain | Residue |
| B | VAL357 |
| B | TYR361 |
| B | ASN393 |
| B | TYR432 |
| B | LYS434 |
| B | PHE516 |
| B | SER520 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue KWP B 607 |
| Chain | Residue |
| B | ARG351 |
| B | ALA356 |
| B | ALA363 |
| B | LEU448 |
| B | ILE451 |
| B | ALA452 |
| B | TYR454 |
| B | GLU481 |
| B | GLY482 |
| B | PRO484 |
| B | HOH793 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK |
| Chain | Residue | Details |
| A | LEU267-LYS290 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE378-VAL390 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP382 | |
| B | ASP382 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU267 | |
| A | LYS290 | |
| A | GLU335 | |
| B | LEU267 | |
| B | LYS290 | |
| B | GLU335 | |
| Chain | Residue | Details |
| A | SER248 | |
| B | SER248 | |
| Chain | Residue | Details |
| A | TYR272 | |
| A | TYR276 | |
| A | TYR432 | |
| B | TYR272 | |
| B | TYR276 | |
| B | TYR432 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036 |
| Chain | Residue | Details |
| A | TYR412 | |
| B | TYR412 | |
| Chain | Residue | Details |
| A | SER465 | |
| B | SER465 | |
