6NO9

PIM1 in complex with Cpd16 (5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0043066	biological_process	negative regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 501

Chain	Residue
A	PHE130
A	ILE133
A	THR134
A	ASP170
A	ASP234
A	GLY238
A	HOH639

---

site_id	AC2
Number of Residues	7
Details	binding site for residue PO4 A 502

Chain	Residue
A	SER261
A	PHE281
A	HOH607
A	HOH611
A	HOH638
A	ARG156
A	ARG258

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 A 503

Chain	Residue
A	GLU142
A	ARG145
A	HOH603
A	HOH604

---

site_id	AC4
Number of Residues	17
Details	binding site for residue KUV A 504

Chain	Residue
A	LEU44
A	PHE49
A	ALA65
A	LYS67
A	ILE104
A	LEU120
A	GLU121
A	ARG122
A	VAL126
A	ASP128
A	GLU171
A	ASN172
A	LEU174
A	ILE185
A	ASP186
A	HOH662
A	HOH674

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK

Chain	Residue	Details
A	LEU44-LYS67

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI

Chain	Residue	Details
A	VAL163-ILE175

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP167

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU44

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862

Chain	Residue	Details
A	LYS67
A	GLU121
A	ASP128

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15657054

Chain	Residue	Details
A	SER98
A	SER261

---