6NMO
Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand SR-4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
| C | 0016114 | biological_process | terpenoid biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 201 |
| Chain | Residue |
| A | ASP10 |
| A | HIS12 |
| A | HIS44 |
| A | MLI203 |
| A | HOH304 |
| A | HOH315 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue DMS A 202 |
| Chain | Residue |
| A | LYS106 |
| A | LEU107 |
| A | LYS134 |
| A | THR135 |
| A | HOH332 |
| A | ALA102 |
| A | GLN103 |
| A | PRO105 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue MLI A 203 |
| Chain | Residue |
| A | HIS12 |
| A | GLY35 |
| A | HIS36 |
| A | SER37 |
| A | HIS44 |
| A | ZN201 |
| A | HOH304 |
| A | HOH315 |
| A | HOH327 |
| A | HOH385 |
| B | HOH367 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue MLI B 201 |
| Chain | Residue |
| A | GLY140 |
| A | TYR141 |
| A | ARG144 |
| B | GLY140 |
| B | TYR141 |
| B | ARG144 |
| B | HOH322 |
| B | HOH344 |
| B | HOH351 |
| B | HOH378 |
| B | HOH401 |
| C | TYR141 |
| C | ARG144 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 202 |
| Chain | Residue |
| B | ASP10 |
| B | HIS12 |
| B | HIS44 |
| B | HOH308 |
| C | HOH306 |
| C | HOH425 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 203 |
| Chain | Residue |
| B | LYS106 |
| B | LEU107 |
| B | ALA108 |
| B | HOH315 |
| B | HOH336 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 204 |
| Chain | Residue |
| B | HOH328 |
| B | HOH389 |
| C | ALA108 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue MLI B 205 |
| Chain | Residue |
| A | TYR9 |
| A | TYR141 |
| A | GLU149 |
| B | TYR9 |
| B | GLU149 |
| B | HOH309 |
| B | HOH311 |
| B | HOH317 |
| C | TYR9 |
| C | TYR141 |
| C | LEU142 |
| C | GLU149 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 201 |
| Chain | Residue |
| C | ASP10 |
| C | HIS12 |
| C | HIS44 |
| C | QMS202 |
| C | HOH325 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue QMS C 202 |
| Chain | Residue |
| A | LYS134 |
| A | GLU137 |
| C | ASP10 |
| C | HIS12 |
| C | LEU34 |
| C | GLY35 |
| C | HIS36 |
| C | ALA39 |
| C | HIS44 |
| C | ILE59 |
| C | ZN201 |
| C | HOH325 |
| C | HOH356 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 203 |
| Chain | Residue |
| C | LYS106 |
| C | LEU107 |
| C | ALA108 |
| C | HOH311 |
| C | HOH367 |
Functional Information from PROSITE/UniProt
| site_id | PS01350 |
| Number of Residues | 16 |
| Details | ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDADVLlHAitDAlfG |
| Chain | Residue | Details |
| A | SER37-GLY52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_00107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
