6NML
Ternary structure of the T130K mutant of ANT-4'' with Neomycin and AMPCPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue NMY A 800 |
| Chain | Residue |
| A | TYR37 |
| A | MG802 |
| A | HOH909 |
| A | HOH917 |
| A | HOH922 |
| A | HOH930 |
| A | HOH936 |
| A | HOH971 |
| A | HOH1003 |
| A | HOH1031 |
| B | GLU141 |
| A | GLU52 |
| B | GLU145 |
| A | GLU63 |
| A | GLU67 |
| A | GLU76 |
| A | ASP80 |
| A | TYR88 |
| A | GLN102 |
| A | APC801 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue APC A 801 |
| Chain | Residue |
| A | GLY38 |
| A | SER39 |
| A | ARG42 |
| A | SER49 |
| A | ASP50 |
| A | GLU52 |
| A | LEU98 |
| A | THR99 |
| A | GLY101 |
| A | GLN102 |
| A | THR186 |
| A | THR187 |
| A | NMY800 |
| A | MG802 |
| A | MG803 |
| A | HOH904 |
| A | HOH945 |
| A | HOH1011 |
| B | GLU145 |
| B | LYS149 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 802 |
| Chain | Residue |
| A | ASP50 |
| A | GLU52 |
| A | NMY800 |
| A | APC801 |
| A | MG803 |
| A | HOH936 |
| B | GLU145 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 803 |
| Chain | Residue |
| A | ASP50 |
| A | GLU52 |
| A | APC801 |
| A | MG802 |
| A | HOH939 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue NMY B 800 |
| Chain | Residue |
| A | GLU141 |
| A | GLU145 |
| B | TYR37 |
| B | GLU52 |
| B | GLU63 |
| B | GLU67 |
| B | GLU76 |
| B | ASP80 |
| B | TYR88 |
| B | GLN102 |
| B | APC801 |
| B | MG802 |
| B | HOH919 |
| B | HOH930 |
| B | HOH955 |
| B | HOH987 |
| B | HOH989 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | binding site for residue APC B 801 |
| Chain | Residue |
| A | GLU145 |
| A | LYS149 |
| A | HOH958 |
| B | GLY38 |
| B | SER39 |
| B | ARG42 |
| B | SER49 |
| B | ASP50 |
| B | GLU52 |
| B | LEU98 |
| B | THR99 |
| B | GLY101 |
| B | GLN102 |
| B | THR186 |
| B | THR187 |
| B | NMY800 |
| B | MG802 |
| B | MG803 |
| B | HOH904 |
| B | HOH915 |
| B | HOH925 |
| B | HOH952 |
| B | HOH999 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| A | GLU145 |
| B | ASP50 |
| B | GLU52 |
| B | NMY800 |
| B | APC801 |
| B | HOH955 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 803 |
| Chain | Residue |
| B | GLU52 |
| B | APC801 |
| B | HOH937 |
| B | ASP50 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 126 |
| Details | Region: {"description":"N-terminal domain","evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8218273","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 226 |
| Details | Region: {"description":"C-terminal domain","evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8218273","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1KNY","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6P06","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38250052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NML","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NMN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21040710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UN8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6UN8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KNY","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38250052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NMK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NML","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UN8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1KNY","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 647 |
| Chain | Residue | Details |
| A | ASP50 | metal ligand |
| A | GLU52 | metal ligand |
| A | GLU145 | activator, proton acceptor, proton donor |
| A | LYS149 | electrostatic stabiliser, polar interaction |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 647 |
| Chain | Residue | Details |
| B | ASP50 | metal ligand |
| B | GLU52 | metal ligand |
| B | GLU145 | activator, proton acceptor, proton donor |
| B | LYS149 | electrostatic stabiliser, polar interaction |
