6NMF
SFX structure of reduced cytochrome c oxidase at room temperature
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004129 | molecular_function | cytochrome-c oxidase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| A | 0006119 | biological_process | oxidative phosphorylation |
| A | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0015990 | biological_process | electron transport coupled proton transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0045277 | cellular_component | respiratory chain complex IV |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070469 | cellular_component | respirasome |
| B | 0004129 | molecular_function | cytochrome-c oxidase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042773 | biological_process | ATP synthesis coupled electron transport |
| B | 0045277 | cellular_component | respiratory chain complex IV |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070469 | cellular_component | respirasome |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0004129 | molecular_function | cytochrome-c oxidase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| C | 0008535 | biological_process | respiratory chain complex IV assembly |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019646 | biological_process | aerobic electron transport chain |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0045277 | cellular_component | respiratory chain complex IV |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| E | 0005743 | cellular_component | mitochondrial inner membrane |
| E | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| E | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| F | 0005740 | cellular_component | mitochondrial envelope |
| F | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| F | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| G | 0005743 | cellular_component | mitochondrial inner membrane |
| G | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005743 | cellular_component | mitochondrial inner membrane |
| H | 0006119 | biological_process | oxidative phosphorylation |
| H | 0016020 | cellular_component | membrane |
| H | 0045277 | cellular_component | respiratory chain complex IV |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005743 | cellular_component | mitochondrial inner membrane |
| I | 0006119 | biological_process | oxidative phosphorylation |
| I | 0016020 | cellular_component | membrane |
| I | 0045277 | cellular_component | respiratory chain complex IV |
| J | 0005746 | cellular_component | mitochondrial respirasome |
| J | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| J | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| K | 0005746 | cellular_component | mitochondrial respirasome |
| K | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| L | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| L | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| M | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| M | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| N | 0004129 | molecular_function | cytochrome-c oxidase activity |
| N | 0005739 | cellular_component | mitochondrion |
| N | 0005743 | cellular_component | mitochondrial inner membrane |
| N | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| N | 0006119 | biological_process | oxidative phosphorylation |
| N | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| N | 0009060 | biological_process | aerobic respiration |
| N | 0015990 | biological_process | electron transport coupled proton transport |
| N | 0016020 | cellular_component | membrane |
| N | 0020037 | molecular_function | heme binding |
| N | 0045277 | cellular_component | respiratory chain complex IV |
| N | 0046872 | molecular_function | metal ion binding |
| N | 0070469 | cellular_component | respirasome |
| O | 0004129 | molecular_function | cytochrome-c oxidase activity |
| O | 0005507 | molecular_function | copper ion binding |
| O | 0005739 | cellular_component | mitochondrion |
| O | 0005743 | cellular_component | mitochondrial inner membrane |
| O | 0016020 | cellular_component | membrane |
| O | 0016491 | molecular_function | oxidoreductase activity |
| O | 0022900 | biological_process | electron transport chain |
| O | 0042773 | biological_process | ATP synthesis coupled electron transport |
| O | 0045277 | cellular_component | respiratory chain complex IV |
| O | 0046872 | molecular_function | metal ion binding |
| O | 0070469 | cellular_component | respirasome |
| O | 1902600 | biological_process | proton transmembrane transport |
| P | 0004129 | molecular_function | cytochrome-c oxidase activity |
| P | 0005739 | cellular_component | mitochondrion |
| P | 0005743 | cellular_component | mitochondrial inner membrane |
| P | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| P | 0008535 | biological_process | respiratory chain complex IV assembly |
| P | 0009055 | molecular_function | electron transfer activity |
| P | 0016020 | cellular_component | membrane |
| P | 0019646 | biological_process | aerobic electron transport chain |
| P | 0022904 | biological_process | respiratory electron transport chain |
| P | 0045277 | cellular_component | respiratory chain complex IV |
| P | 1902600 | biological_process | proton transmembrane transport |
| Q | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| Q | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| R | 0005743 | cellular_component | mitochondrial inner membrane |
| R | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| R | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| S | 0005740 | cellular_component | mitochondrial envelope |
| S | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| S | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| T | 0005743 | cellular_component | mitochondrial inner membrane |
| T | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| U | 0005739 | cellular_component | mitochondrion |
| U | 0005743 | cellular_component | mitochondrial inner membrane |
| U | 0006119 | biological_process | oxidative phosphorylation |
| U | 0016020 | cellular_component | membrane |
| U | 0045277 | cellular_component | respiratory chain complex IV |
| V | 0005739 | cellular_component | mitochondrion |
| V | 0005743 | cellular_component | mitochondrial inner membrane |
| V | 0006119 | biological_process | oxidative phosphorylation |
| V | 0016020 | cellular_component | membrane |
| V | 0045277 | cellular_component | respiratory chain complex IV |
| W | 0005746 | cellular_component | mitochondrial respirasome |
| W | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| W | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| X | 0005746 | cellular_component | mitochondrial respirasome |
| X | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Y | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| Y | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Z | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| Z | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue HEA A 601 |
| Chain | Residue |
| A | THR31 |
| A | VAL70 |
| A | GLY125 |
| A | TRP126 |
| A | TYR371 |
| A | PHE377 |
| A | HIS378 |
| A | LEU381 |
| A | SER382 |
| A | PHE425 |
| A | GLN428 |
| A | SER34 |
| A | ARG438 |
| A | ARG439 |
| A | VAL465 |
| A | HOH712 |
| A | HOH740 |
| A | ILE37 |
| A | ARG38 |
| A | TYR54 |
| A | VAL58 |
| A | HIS61 |
| A | ALA62 |
| A | MET65 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | binding site for residue HEA A 602 |
| Chain | Residue |
| A | TRP126 |
| A | TRP236 |
| A | VAL243 |
| A | TYR244 |
| A | ILE247 |
| A | HIS290 |
| A | HIS291 |
| A | THR309 |
| A | ILE312 |
| A | GLY317 |
| A | GLY352 |
| A | GLY355 |
| A | LEU358 |
| A | ALA359 |
| A | ASP364 |
| A | HIS368 |
| A | VAL373 |
| A | HIS376 |
| A | PHE377 |
| A | VAL380 |
| A | LEU381 |
| A | ARG438 |
| A | HOH709 |
| A | HOH716 |
| A | HOH725 |
| A | HOH765 |
| B | ILE34 |
| B | ILE72 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CU A 603 |
| Chain | Residue |
| A | HIS240 |
| A | HIS290 |
| A | HIS291 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | HIS368 |
| A | ASP369 |
| B | GLU198 |
| B | HOH401 |
| B | HOH409 |
| B | HOH458 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 605 |
| Chain | Residue |
| A | GLU40 |
| A | GLY45 |
| A | SER441 |
| A | HOH784 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue PGV A 606 |
| Chain | Residue |
| A | PHE94 |
| A | PRO95 |
| A | ARG96 |
| A | MET97 |
| C | HIS9 |
| C | MET27 |
| C | ASN50 |
| C | MET54 |
| C | TRP57 |
| C | TRP58 |
| C | GLU64 |
| C | HIS71 |
| C | PEK302 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue PGV A 607 |
| Chain | Residue |
| A | ASN406 |
| A | THR408 |
| A | TRP409 |
| A | HOH793 |
| D | PHE87 |
| M | LYS4 |
| M | PRO12 |
| M | GLN15 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue TGL A 608 |
| Chain | Residue |
| A | PHE2 |
| A | THR17 |
| A | LEU18 |
| A | TRP25 |
| A | PHE400 |
| A | HOH722 |
| L | ASN10 |
| L | ILE11 |
| L | PRO12 |
| L | MET24 |
| L | PHE29 |
| L | HOH109 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | binding site for residue CDL A 609 |
| Chain | Residue |
| A | TYR304 |
| A | SER307 |
| A | ILE311 |
| A | HOH701 |
| A | HOH718 |
| A | HOH755 |
| A | HOH820 |
| B | ALA70 |
| B | LEU78 |
| B | TYR85 |
| B | HOH464 |
| C | HOH453 |
| P | LEU131 |
| P | PHE251 |
| P | PEK309 |
| P | HOH428 |
| T | SER27 |
| T | CYS31 |
| T | ASN34 |
| T | LEU37 |
| T | HIS38 |
| T | PEK101 |
| T | HOH202 |
| T | HOH220 |
| A | ASP300 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue TGL B 301 |
| Chain | Residue |
| A | LEU433 |
| B | LEU28 |
| B | HOH454 |
| B | HOH467 |
| I | ARG43 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue CUA B 302 |
| Chain | Residue |
| B | HIS161 |
| B | CYS196 |
| B | GLU198 |
| B | CYS200 |
| B | HIS204 |
| B | MET207 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue CHD B 303 |
| Chain | Residue |
| B | GLN59 |
| B | GLU62 |
| B | THR63 |
| B | HOH425 |
| P | PEK309 |
| T | ARG14 |
| T | PHE18 |
| T | GLY22 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue PSC B 304 |
| Chain | Residue |
| A | PHE321 |
| B | ILE41 |
| B | MET45 |
| B | ASP57 |
| B | TRP65 |
| B | LEU68 |
| B | HOH408 |
| E | ASP8 |
| I | LEU17 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue DMU C 301 |
| Chain | Residue |
| C | MET33 |
| C | PHE37 |
| J | SER46 |
| J | TYR48 |
| J | CYS49 |
| J | LEU50 |
| J | TRP52 |
| site_id | AD6 |
| Number of Residues | 17 |
| Details | binding site for residue PEK C 302 |
| Chain | Residue |
| A | HIS151 |
| A | PGV606 |
| C | TYR181 |
| C | TYR182 |
| C | ALA184 |
| C | PHE186 |
| C | THR187 |
| C | ILE188 |
| C | PHE198 |
| C | HOH407 |
| C | HOH447 |
| G | TRP62 |
| G | THR68 |
| G | PHE69 |
| G | PHE70 |
| G | HIS71 |
| G | ASN76 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for residue PGV C 303 |
| Chain | Residue |
| C | SER65 |
| C | THR66 |
| C | ILE210 |
| C | PHE214 |
| C | ARG221 |
| C | HIS226 |
| C | PHE227 |
| C | HIS231 |
| C | PHE233 |
| C | GLY234 |
| F | HOH205 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue CDL C 304 |
| Chain | Residue |
| C | MET51 |
| C | TYR55 |
| C | ARG63 |
| C | PHE220 |
| C | LYS224 |
| C | HIS226 |
| C | HOH426 |
| J | LYS8 |
| J | ASP28 |
| J | HOH209 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue CHD C 305 |
| Chain | Residue |
| C | ARG156 |
| C | GLN161 |
| C | PHE164 |
| J | PHE1 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue CHD C 306 |
| Chain | Residue |
| A | HIS233 |
| A | ASP300 |
| A | THR301 |
| A | TYR304 |
| C | TRP99 |
| C | HIS103 |
| C | PGV307 |
| C | HOH430 |
| C | HOH439 |
| site_id | AE2 |
| Number of Residues | 11 |
| Details | binding site for residue PGV C 307 |
| Chain | Residue |
| A | HOH706 |
| C | TRP99 |
| C | TYR102 |
| C | HIS103 |
| C | LEU106 |
| C | ALA107 |
| C | CHD306 |
| C | HOH429 |
| C | HOH450 |
| H | ASN24 |
| H | HOH105 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue TGL D 201 |
| Chain | Residue |
| A | TRP334 |
| A | LYS411 |
| A | ALA415 |
| D | ARG73 |
| D | THR75 |
| D | GLU77 |
| D | TRP78 |
| I | HIS20 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 101 |
| Chain | Residue |
| F | CYS60 |
| F | CYS62 |
| F | CYS82 |
| F | CYS85 |
| site_id | AE5 |
| Number of Residues | 9 |
| Details | binding site for residue PEK G 101 |
| Chain | Residue |
| C | LYS157 |
| C | HIS158 |
| C | GLN161 |
| C | HOH454 |
| F | ALA1 |
| G | ARG17 |
| G | CDL102 |
| G | CHD104 |
| O | GLN59 |
| site_id | AE6 |
| Number of Residues | 20 |
| Details | binding site for residue CDL G 102 |
| Chain | Residue |
| C | LEU127 |
| C | LEU131 |
| C | LEU138 |
| C | HOH424 |
| G | CYS31 |
| G | ASN34 |
| G | HIS38 |
| G | PEK101 |
| G | PEK103 |
| G | HOH207 |
| G | HOH218 |
| N | PHE282 |
| N | ASP300 |
| N | TYR304 |
| N | SER307 |
| N | ILE311 |
| O | LEU78 |
| O | LEU81 |
| O | TYR85 |
| P | CHD307 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue PEK G 103 |
| Chain | Residue |
| G | SER2 |
| G | LYS5 |
| G | HIS8 |
| G | CDL102 |
| G | HOH202 |
| P | ILE84 |
| P | TRP240 |
| P | PHE251 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue CHD G 104 |
| Chain | Residue |
| G | ARG14 |
| G | ARG17 |
| G | GLY22 |
| G | PEK101 |
| G | HOH201 |
| N | MET271 |
| O | GLN59 |
| O | GLU62 |
| O | THR63 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue CHD J 101 |
| Chain | Residue |
| A | LEU7 |
| J | TYR32 |
| J | ARG33 |
| J | THR37 |
| J | LEU40 |
| J | HOH205 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue DMU M 101 |
| Chain | Residue |
| D | TRP98 |
| M | LEU28 |
| M | TRP32 |
| M | TYR35 |
| M | HIS36 |
| site_id | AF2 |
| Number of Residues | 23 |
| Details | binding site for residue HEA N 601 |
| Chain | Residue |
| N | THR31 |
| N | SER34 |
| N | ARG38 |
| N | TYR54 |
| N | VAL58 |
| N | HIS61 |
| N | ALA62 |
| N | MET65 |
| N | VAL70 |
| N | GLY125 |
| N | TRP126 |
| N | TYR371 |
| N | PHE377 |
| N | HIS378 |
| N | SER382 |
| N | MET417 |
| N | PHE425 |
| N | GLN428 |
| N | ARG438 |
| N | ARG439 |
| N | TYR440 |
| N | MET468 |
| N | HOH714 |
| site_id | AF3 |
| Number of Residues | 25 |
| Details | binding site for residue HEA N 602 |
| Chain | Residue |
| N | TRP126 |
| N | TRP236 |
| N | VAL243 |
| N | TYR244 |
| N | ILE247 |
| N | HIS290 |
| N | HIS291 |
| N | THR309 |
| N | ILE312 |
| N | THR316 |
| N | GLY317 |
| N | GLY352 |
| N | GLY355 |
| N | LEU358 |
| N | ALA359 |
| N | ASP364 |
| N | HIS368 |
| N | VAL373 |
| N | HIS376 |
| N | PHE377 |
| N | VAL380 |
| N | ARG438 |
| N | HOH701 |
| N | HOH719 |
| N | HOH737 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue CU N 603 |
| Chain | Residue |
| N | HIS240 |
| N | HIS290 |
| N | HIS291 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue MG N 604 |
| Chain | Residue |
| N | HIS368 |
| N | ASP369 |
| O | GLU198 |
| O | HOH401 |
| O | HOH422 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue NA N 605 |
| Chain | Residue |
| N | GLU40 |
| N | GLY45 |
| N | SER441 |
| N | HOH774 |
| site_id | AF7 |
| Number of Residues | 9 |
| Details | binding site for residue PGV N 606 |
| Chain | Residue |
| N | ASN406 |
| N | THR408 |
| N | TRP409 |
| N | HOH761 |
| Q | ALA84 |
| Q | PHE87 |
| X | HIS10 |
| Z | PRO12 |
| Z | GLN15 |
| site_id | AF8 |
| Number of Residues | 8 |
| Details | binding site for residue TGL N 607 |
| Chain | Residue |
| N | ILE332 |
| N | TRP334 |
| N | HOH762 |
| O | LEU46 |
| Q | GLU77 |
| Q | TRP78 |
| Q | MET86 |
| V | ARG16 |
| site_id | AF9 |
| Number of Residues | 10 |
| Details | binding site for residue PSC N 608 |
| Chain | Residue |
| N | PHE321 |
| N | HIS328 |
| O | ILE41 |
| O | HIS52 |
| O | MET56 |
| O | ASP57 |
| O | TRP65 |
| R | THR7 |
| R | ASP8 |
| V | ARG10 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue CUA O 301 |
| Chain | Residue |
| O | HIS161 |
| O | CYS196 |
| O | GLU198 |
| O | CYS200 |
| O | HIS204 |
| O | MET207 |
| site_id | AG2 |
| Number of Residues | 13 |
| Details | binding site for residue PGV P 301 |
| Chain | Residue |
| N | PHE94 |
| N | PRO95 |
| N | ARG96 |
| N | MET97 |
| N | HOH711 |
| P | HIS9 |
| P | ALA24 |
| P | TRP57 |
| P | TRP58 |
| P | GLU64 |
| P | HIS71 |
| P | LEU79 |
| P | HOH432 |
| site_id | AG3 |
| Number of Residues | 8 |
| Details | binding site for residue PGV P 302 |
| Chain | Residue |
| G | ALA1 |
| N | ASP298 |
| P | TRP99 |
| P | TYR102 |
| P | HIS103 |
| P | ALA107 |
| P | CHD307 |
| U | ASN22 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue DMU P 303 |
| Chain | Residue |
| P | MET33 |
| P | PHE37 |
| W | SER46 |
| W | CYS49 |
| W | TRP52 |
| W | ALA53 |
| site_id | AG5 |
| Number of Residues | 17 |
| Details | binding site for residue PGV P 304 |
| Chain | Residue |
| P | TRP58 |
| P | VAL61 |
| P | SER65 |
| P | THR66 |
| P | ILE210 |
| P | PHE214 |
| P | ARG221 |
| P | HIS226 |
| P | PHE227 |
| P | HIS231 |
| P | HIS232 |
| P | PHE233 |
| P | GLY234 |
| P | CDL305 |
| P | HOH403 |
| P | HOH410 |
| P | HOH432 |
| site_id | AG6 |
| Number of Residues | 16 |
| Details | binding site for residue CDL P 305 |
| Chain | Residue |
| P | MET51 |
| P | TYR55 |
| P | TRP58 |
| P | ARG59 |
| P | ILE62 |
| P | ARG63 |
| P | PHE67 |
| P | VAL217 |
| P | PHE220 |
| P | ARG221 |
| P | LYS224 |
| P | HIS226 |
| P | PGV304 |
| P | HOH410 |
| W | LYS8 |
| W | THR27 |
| site_id | AG7 |
| Number of Residues | 2 |
| Details | binding site for residue CHD P 306 |
| Chain | Residue |
| P | ARG156 |
| P | PHE164 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue CHD P 307 |
| Chain | Residue |
| G | CDL102 |
| N | HIS233 |
| N | THR301 |
| N | TYR304 |
| P | TRP99 |
| P | HIS103 |
| P | PGV302 |
| site_id | AG9 |
| Number of Residues | 14 |
| Details | binding site for residue PEK P 308 |
| Chain | Residue |
| P | TYR181 |
| P | TYR182 |
| P | ALA184 |
| P | PHE186 |
| P | THR187 |
| P | ILE188 |
| P | PHE198 |
| P | HOH402 |
| P | HOH439 |
| T | THR68 |
| T | PHE69 |
| T | PHE70 |
| T | HIS71 |
| T | ASN76 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue PEK P 309 |
| Chain | Residue |
| A | CDL609 |
| B | CHD303 |
| P | GLN161 |
| P | HOH431 |
| T | ARG17 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue DMU Q 201 |
| Chain | Residue |
| Q | LEU95 |
| Q | TRP98 |
| Q | TYR102 |
| Z | LEU27 |
| Z | LEU28 |
| Z | TYR35 |
| site_id | AH3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN S 101 |
| Chain | Residue |
| S | CYS60 |
| S | CYS62 |
| S | CYS82 |
| S | CYS85 |
| S | THR87 |
| site_id | AH4 |
| Number of Residues | 11 |
| Details | binding site for residue PEK T 101 |
| Chain | Residue |
| A | CDL609 |
| C | ARG80 |
| C | TYR81 |
| C | TRP240 |
| T | SER2 |
| T | ALA3 |
| T | LYS5 |
| T | GLY6 |
| T | HIS8 |
| T | TPO11 |
| T | HOH208 |
| site_id | AH5 |
| Number of Residues | 8 |
| Details | binding site for residue TGL V 101 |
| Chain | Residue |
| N | ASN422 |
| N | LEU433 |
| O | LEU7 |
| O | LEU28 |
| O | PHE32 |
| V | ARG43 |
| V | HOH204 |
| V | HOH212 |
| site_id | AH6 |
| Number of Residues | 3 |
| Details | binding site for residue CHD W 101 |
| Chain | Residue |
| N | ILE3 |
| W | ARG33 |
| W | HOH204 |
| site_id | AH7 |
| Number of Residues | 8 |
| Details | binding site for residue TGL Y 101 |
| Chain | Residue |
| N | THR17 |
| N | PHE400 |
| Y | PRO12 |
| Y | PHE13 |
| Y | MET24 |
| Y | PHE28 |
| Y | PHE29 |
| Y | HOH201 |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 56 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH |
| Chain | Residue | Details |
| A | TRP236-HIS291 |
| site_id | PS01329 |
| Number of Residues | 18 |
| Details | COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN |
| Chain | Residue | Details |
| G | ILE55-ASN72 |
| site_id | PS00848 |
| Number of Residues | 23 |
| Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL |
| Chain | Residue | Details |
| F | VAL69-LEU91 |
| site_id | PS00078 |
| Number of Residues | 49 |
| Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM |
| Chain | Residue | Details |
| B | VAL159-MET207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| M | ILE1-SER11 | |
| N | SER262-GLY269 | |
| N | SER401-ASN406 | |
| N | LYS479-LYS514 | |
| Z | ILE1-SER11 | |
| F | CYS82 | |
| F | CYS85 | |
| S | CYS60 | |
| S | CYS62 | |
| S | CYS82 | |
| S | CYS85 | |
| N | MET171-PRO182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| M | PRO12-TYR35 | |
| Z | PRO12-TYR35 | |
| F | LYS90 | |
| S | LYS37 | |
| S | LYS55 | |
| S | LYS90 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| M | HIS36-ALA46 | |
| Z | HIS36-ALA46 | |
| C | ALA184-ASP190 | |
| C | TYR257-SER261 | |
| P | PHE35-MET40 | |
| P | LEU106-GLU128 | |
| P | ALA184-ASP190 | |
| P | TYR257-SER261 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P17665 |
| Chain | Residue | Details |
| L | LYS9 | |
| Y | LYS9 | |
| Q | LYS7 | |
| Q | LYS38 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P13073 |
| Chain | Residue | Details |
| D | LYS31 | |
| O | CYS200 | |
| O | HIS204 | |
| O | MET207 | |
| Q | LYS31 | |
| B | GLU198 | |
| B | CYS200 | |
| B | HIS204 | |
| B | MET207 | |
| O | HIS161 | |
| O | CYS196 | |
| O | GLU198 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10888 |
| Chain | Residue | Details |
| D | SER34 | |
| D | SER36 | |
| Q | SER34 | |
| Q | SER36 | |
| N | ARG213-ASP227 | |
| N | VAL287-ASP298 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19783 |
| Chain | Residue | Details |
| D | LYS45 | |
| Q | LYS45 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 64 |
| Details | TRANSMEM: Helical; Name=VI => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | GLY191-LEU223 | |
| P | GLY191-LEU223 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | PHE233-ILE256 | |
| P | PHE233-ILE256 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR270-ILE286 | |
| N | TYR270-ILE286 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=VIII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | VAL299-LEU327 | |
| N | VAL299-LEU327 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 14 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | HIS328-SER335 | |
| N | HIS328-SER335 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=IX => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | PRO336-VAL357 | |
| N | PRO336-VAL357 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 48 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | LEU358-THR370 | |
| A | SER434-ALA446 | |
| N | LEU358-THR370 | |
| N | SER434-ALA446 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 58 |
| Details | TRANSMEM: Helical; Name=X => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR371-PHE400 | |
| N | TYR371-PHE400 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=XI => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | ASP407-LEU433 | |
| N | ASP407-LEU433 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 62 |
| Details | TRANSMEM: Helical; Name=XII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR447-SER478 | |
| N | TYR447-SER478 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 |
| Chain | Residue | Details |
| A | GLU40 | |
| A | GLY45 | |
| A | SER441 | |
| N | GLU40 | |
| N | GLY45 | |
| N | SER441 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 6 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| A | HIS61 | |
| A | HIS376 | |
| A | HIS378 | |
| N | HIS61 | |
| N | HIS376 | |
| N | HIS378 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| A | HIS240 | |
| N | ASP369 | |
| A | HIS290 | |
| A | HIS291 | |
| A | HIS368 | |
| A | ASP369 | |
| N | HIS240 | |
| N | HIS290 | |
| N | HIS291 | |
| N | HIS368 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR244 | |
| N | TYR244 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: N-formylmethionine => ECO:0000269|PubMed:2165784 |
| Chain | Residue | Details |
| A | FME1 | |
| N | FME1 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009 |
| Chain | Residue | Details |
| A | HIS240 | |
| A | TYR244 | |
| N | HIS240 | |
| N | TYR244 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 14 |
| Details | M-CSA 124 |
| Chain | Residue | Details |
| A | HIS61 | metal ligand |
| A | HIS290 | metal ligand |
| A | HIS291 | metal ligand, proton acceptor, proton donor |
| A | THR316 | proton acceptor, proton donor, proton relay |
| A | LYS319 | proton acceptor, proton donor, proton relay |
| A | ARG438 | proton acceptor, proton donor, proton relay |
| A | ASP91 | proton acceptor, proton donor, proton relay |
| A | TRP126 | proton acceptor, proton donor, proton relay |
| A | SER156 | proton acceptor, proton donor, proton relay |
| A | SER157 | proton acceptor, proton donor, proton relay |
| A | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
| A | GLU242 | proton acceptor, proton donor, proton relay |
| A | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
| A | SER255 | proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 14 |
| Details | M-CSA 124 |
| Chain | Residue | Details |
| N | HIS61 | metal ligand |
| N | HIS290 | metal ligand |
| N | HIS291 | metal ligand, proton acceptor, proton donor |
| N | THR316 | proton acceptor, proton donor, proton relay |
| N | LYS319 | proton acceptor, proton donor, proton relay |
| N | ARG438 | proton acceptor, proton donor, proton relay |
| N | ASP91 | proton acceptor, proton donor, proton relay |
| N | TRP126 | proton acceptor, proton donor, proton relay |
| N | SER156 | proton acceptor, proton donor, proton relay |
| N | SER157 | proton acceptor, proton donor, proton relay |
| N | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
| N | GLU242 | proton acceptor, proton donor, proton relay |
| N | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
| N | SER255 | proton acceptor, proton donor, proton relay |
