Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NLH

Structure of human triose phosphate isomerase R189A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0008929	molecular_function	methylglyoxal synthase activity
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0019242	biological_process	methylglyoxal biosynthetic process
A	0019563	biological_process	glycerol catabolic process
A	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0042803	molecular_function	protein homodimerization activity
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
A	0061621	biological_process	canonical glycolysis
A	0070062	cellular_component	extracellular exosome
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0008929	molecular_function	methylglyoxal synthase activity
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0019242	biological_process	methylglyoxal biosynthetic process
B	0019563	biological_process	glycerol catabolic process
B	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0042803	molecular_function	protein homodimerization activity
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0061621	biological_process	canonical glycolysis
B	0070062	cellular_component	extracellular exosome
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0008929	molecular_function	methylglyoxal synthase activity
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0019242	biological_process	methylglyoxal biosynthetic process
C	0019563	biological_process	glycerol catabolic process
C	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0042803	molecular_function	protein homodimerization activity
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0061621	biological_process	canonical glycolysis
C	0070062	cellular_component	extracellular exosome
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0008929	molecular_function	methylglyoxal synthase activity
D	0016829	molecular_function	lyase activity
D	0016853	molecular_function	isomerase activity
D	0019242	biological_process	methylglyoxal biosynthetic process
D	0019563	biological_process	glycerol catabolic process
D	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0042803	molecular_function	protein homodimerization activity
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0061621	biological_process	canonical glycolysis
D	0070062	cellular_component	extracellular exosome
E	0004807	molecular_function	triose-phosphate isomerase activity
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006006	biological_process	glucose metabolic process
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0008929	molecular_function	methylglyoxal synthase activity
E	0016829	molecular_function	lyase activity
E	0016853	molecular_function	isomerase activity
E	0019242	biological_process	methylglyoxal biosynthetic process
E	0019563	biological_process	glycerol catabolic process
E	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0042803	molecular_function	protein homodimerization activity
E	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
E	0061621	biological_process	canonical glycolysis
E	0070062	cellular_component	extracellular exosome
F	0004807	molecular_function	triose-phosphate isomerase activity
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0008929	molecular_function	methylglyoxal synthase activity
F	0016829	molecular_function	lyase activity
F	0016853	molecular_function	isomerase activity
F	0019242	biological_process	methylglyoxal biosynthetic process
F	0019563	biological_process	glycerol catabolic process
F	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0042803	molecular_function	protein homodimerization activity
F	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
F	0061621	biological_process	canonical glycolysis
F	0070062	cellular_component	extracellular exosome
G	0004807	molecular_function	triose-phosphate isomerase activity
G	0005515	molecular_function	protein binding
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006006	biological_process	glucose metabolic process
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0008929	molecular_function	methylglyoxal synthase activity
G	0016829	molecular_function	lyase activity
G	0016853	molecular_function	isomerase activity
G	0019242	biological_process	methylglyoxal biosynthetic process
G	0019563	biological_process	glycerol catabolic process
G	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0042803	molecular_function	protein homodimerization activity
G	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
G	0061621	biological_process	canonical glycolysis
G	0070062	cellular_component	extracellular exosome
H	0004807	molecular_function	triose-phosphate isomerase activity
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006006	biological_process	glucose metabolic process
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0008929	molecular_function	methylglyoxal synthase activity
H	0016829	molecular_function	lyase activity
H	0016853	molecular_function	isomerase activity
H	0019242	biological_process	methylglyoxal biosynthetic process
H	0019563	biological_process	glycerol catabolic process
H	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0042803	molecular_function	protein homodimerization activity
H	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
H	0061621	biological_process	canonical glycolysis
H	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NA A 301

Chain	Residue
A	ALA221
A	GLN223
A	VAL226
A	HOH502

site_id	AC2
Number of Residues	3
Details	binding site for residue NA A 302

Chain	Residue
A	ARG99
A	ASP106
A	GLN146

site_id	AC3
Number of Residues	4
Details	binding site for residue NA A 303

Chain	Residue
H	VAL69
H	THR70
A	SER194
A	ASN195

site_id	AC4
Number of Residues	3
Details	binding site for residue NA E 301

Chain	Residue
E	ALA221
E	GLN223
E	VAL226

site_id	AC5
Number of Residues	3
Details	binding site for residue BR E 302

Chain	Residue
E	ASN11
E	HIS95
E	LEU230

site_id	AC6
Number of Residues	6
Details	binding site for residue PO4 E 303

Chain	Residue
E	LYS13
E	SER211
E	GLY232
E	GLY233
E	HOH401
E	HOH417

site_id	AC7
Number of Residues	5
Details	binding site for residue NA B 301

Chain	Residue
B	ALA221
B	GLN223
B	VAL226
B	HOH429
B	HOH500

site_id	AC8
Number of Residues	2
Details	binding site for residue NA B 302

Chain	Residue
B	VAL39
B	LYS58

site_id	AC9
Number of Residues	3
Details	binding site for residue NA B 303

Chain	Residue
B	ARG98
B	GLU104
B	HOH456

site_id	AD1
Number of Residues	4
Details	binding site for residue NA B 304

Chain	Residue
B	SER194
B	ASN195
F	VAL69
F	THR70

site_id	AD2
Number of Residues	5
Details	binding site for residue NA C 301

Chain	Residue
B	ARG98
B	HOH405
C	GLU77
C	ARG98
C	HOH410

site_id	AD3
Number of Residues	4
Details	binding site for residue NA C 302

Chain	Residue
C	ALA221
C	GLN223
C	VAL226
C	LYS247

site_id	AD4
Number of Residues	3
Details	binding site for residue NA C 303

Chain	Residue
C	ARG99
C	ASP106
C	GLN146

site_id	AD5
Number of Residues	3
Details	binding site for residue BR C 304

Chain	Residue
C	ASN11
C	HIS95
C	HOH433

site_id	AD6
Number of Residues	6
Details	binding site for residue PO4 C 305

Chain	Residue
C	LYS13
C	GLY210
C	GLY232
C	GLY233
C	HOH433
C	HOH448

site_id	AD7
Number of Residues	4
Details	binding site for residue NA D 301

Chain	Residue
D	ALA221
D	GLN223
D	VAL226
D	HOH482

site_id	AD8
Number of Residues	3
Details	binding site for residue NA D 302

Chain	Residue
D	ARG99
D	ASP106
D	GLN146

site_id	AD9
Number of Residues	4
Details	binding site for residue NA D 303

Chain	Residue
C	VAL69
C	THR70
D	SER194
D	ASN195

site_id	AE1
Number of Residues	4
Details	binding site for residue NA F 301

Chain	Residue
F	ALA221
F	GLN223
F	VAL226
F	LYS247

site_id	AE2
Number of Residues	4
Details	binding site for residue NA F 302

Chain	Residue
F	GLU38
F	ALA60
F	TRP90
F	HOH465

site_id	AE3
Number of Residues	3
Details	binding site for residue BR F 303

Chain	Residue
F	ASN11
F	HIS95
F	HOH433

site_id	AE4
Number of Residues	4
Details	binding site for residue PO4 F 304

Chain	Residue
F	LYS13
F	GLY232
F	GLY233
F	HOH401

site_id	AE5
Number of Residues	3
Details	binding site for residue NA G 301

Chain	Residue
G	ARG99
G	ASP106
G	GLN146

site_id	AE6
Number of Residues	4
Details	binding site for residue NA G 302

Chain	Residue
G	ALA221
G	GLN223
G	VAL226
G	HOH475

site_id	AE7
Number of Residues	3
Details	binding site for residue NA H 301

Chain	Residue
H	ARG99
H	ASP106
H	GLN146

site_id	AE8
Number of Residues	4
Details	binding site for residue NA H 302

Chain	Residue
H	ALA221
H	GLN223
H	VAL226
H	LYS247

site_id	AE9
Number of Residues	2
Details	binding site for residue BR H 303

Chain	Residue
H	HIS95
H	ASN11

site_id	AF1
Number of Residues	5
Details	binding site for residue PO4 H 304

Chain	Residue
H	LYS13
H	SER211
H	GLY232
H	GLY233
H	HOH401

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG

Chain	Residue	Details
A	ALA163-GLY173

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Electrophile => ECO:0000255\|PROSITE-ProRule:PRU10127, ECO:0000269\|PubMed:8061610

Chain	Residue	Details
A	LYS58
E	LYS58
B	LYS58
C	LYS58
D	LYS58
F	LYS58
G	LYS58
H	LYS58

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10127, ECO:0000269\|PubMed:8061610

Chain	Residue	Details
A	GLY128
E	GLY128
B	GLY128
C	GLY128
D	GLY128
F	GLY128
G	GLY128
H	GLY128

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	ALA30
D	GLY171
F	ALA30
F	GLY171
G	ALA30
G	GLY171
H	ALA30
H	GLY171
A	GLY171
E	ALA30
E	GLY171
B	ALA30
B	GLY171
C	ALA30
C	GLY171
D	ALA30

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	ALA42
E	ALA42
B	ALA42
C	ALA42
D	ALA42
F	ALA42
G	ALA42
H	ALA42

site_id	SWS_FT_FI5
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P48500

Chain	Residue	Details
A	LYS68
D	VAL160
F	LYS68
F	VAL160
G	LYS68
G	VAL160
H	LYS68
H	VAL160
A	VAL160
E	LYS68
E	VAL160
B	LYS68
B	VAL160
C	LYS68
C	VAL160
D	LYS68

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	GLN111
E	GLN111
B	GLN111
C	GLN111
D	GLN111
F	GLN111
G	GLN111
H	GLN111

site_id	SWS_FT_FI7
Number of Residues	16
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	ALA118
D	ASP156
F	ALA118
F	ASP156
G	ALA118
G	ASP156
H	ALA118
H	ASP156
A	ASP156
E	ALA118
E	ASP156
B	ALA118
B	ASP156
C	ALA118
C	ASP156
D	ALA118

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	LEU121
E	LEU121
B	LEU121
C	LEU121
D	LEU121
F	LEU121
G	LEU121
H	LEU121

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P17751

Chain	Residue	Details
A	GLU135
E	GLU135
B	GLU135
C	GLU135
D	GLU135
F	GLU135
G	GLU135
H	GLU135

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	LYS174
E	LYS174
B	LYS174
C	LYS174
D	LYS174
F	LYS174
G	LYS174
H	LYS174

site_id	SWS_FT_FI11
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	ALA176
E	ALA176
B	ALA176
C	ALA176
D	ALA176
F	ALA176
G	ALA176
H	ALA176

site_id	SWS_FT_FI12
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	HIS185
E	HIS185
B	HIS185
C	HIS185
D	HIS185
F	HIS185
G	HIS185
H	HIS185

site_id	SWS_FT_FI13
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	VAL200
E	VAL200
B	VAL200
C	VAL200
D	VAL200
F	VAL200
G	VAL200
H	VAL200

site_id	SWS_FT_FI14
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744\|PubMed:25114211

Chain	Residue	Details
A	GLU104
F	GLU104
G	GLU104
H	GLU104
E	GLU104
B	GLU104
C	GLU104
D	GLU104

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)