6NJU

Mouse endonuclease G mutant H97A bound to A-DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0003676	molecular_function	nucleic acid binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0003676	molecular_function	nucleic acid binding
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0003676	molecular_function	nucleic acid binding
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 301

Chain	Residue
A	ASN128
A	HOH401
A	HOH404
A	HOH405
A	HOH428

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 302

Chain	Residue
A	ARG59
A	HIS104
A	TRP106

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site_id	AC3
Number of Residues	5
Details	binding site for residue MG B 301

Chain	Residue
B	HOH408
B	HOH414
B	HOH419
B	HOH424
B	ASN128

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site_id	AC4
Number of Residues	5
Details	binding site for residue MG C 301

Chain	Residue
C	ASN128
C	HOH413
C	HOH418
C	HOH421
C	HOH422

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL C 302

Chain	Residue
C	ARG59
C	HIS104
C	TRP106

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CL C 303

Chain	Residue
C	HIS78

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site_id	AC7
Number of Residues	4
Details	binding site for residue MG D 301

Chain	Residue
D	ASN128
D	HOH406
D	HOH425
D	HOH426

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site_id	AC8
Number of Residues	2
Details	binding site for residue CL D 302

Chain	Residue
D	ILE174
D	GLY175

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site_id	AC9
Number of Residues	7
Details	binding site for residue TRS E 101

Chain	Residue
D	ASP75
E	DC2
E	DG3
E	DG4
E	DC7
E	HOH203
E	HOH204

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10047, ECO:0000269|PubMed:32095813, ECO:0000269|PubMed:32192768

Chain	Residue	Details
A	ALA97
B	ALA97
C	ALA97
D	ALA97

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:32095813, ECO:0000269|PubMed:32192768, ECO:0007744|PDB:6LYF, ECO:0007744|PDB:6NJT

Chain	Residue	Details
A	ASN128
B	ASN128
C	ASN128
D	ASN128

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Essential for catalytic activity => ECO:0000269|PubMed:32192768

Chain	Residue	Details
A	ARG66
B	ARG66
C	ARG66
D	ARG66

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q14249

Chain	Residue	Details
A	THR84
B	THR84
C	THR84
D	THR84

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